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Aliases for ZNF644 Gene

Aliases for ZNF644 Gene

  • Zinc Finger Protein 644 2 3 3 5
  • Zinc Finger Motif Enhancer Binding Protein 2 3
  • Zinc Finger Motif Enhancer-Binding Protein 2 4
  • KIAA1221 4
  • BM-005 3
  • MYP21 3
  • ZEP-2 3
  • Zep-2 4
  • NatF 3
  • ZEP2 4

External Ids for ZNF644 Gene

Previous GeneCards Identifiers for ZNF644 Gene

  • GC01M091093
  • GC01M091153
  • GC01M091380
  • GC01M089499

Summaries for ZNF644 Gene

Entrez Gene Summary for ZNF644 Gene

  • The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZNF644 Gene

ZNF644 (Zinc Finger Protein 644) is a Protein Coding gene. Diseases associated with ZNF644 include Myopia 21, Autosomal Dominant and Refractive Error. An important paralog of this gene is WIZ.

UniProtKB/Swiss-Prot for ZNF644 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF644 Gene

Additional gene information for ZNF644 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF644 Gene

Genomics for ZNF644 Gene

GeneHancer (GH) Regulatory Elements for ZNF644 Gene

Promoters and enhancers for ZNF644 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J091019 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 656 +0.6 605 3.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF644 PIR51118
GH01J091882 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 -862.8 -862767 4.4 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF213 TGFBR3 HFM1 SNORA66 SNORD21 RPL5 GLMN BTBD8 RPAP2 ZNF644 GC01M091855
GH01J091499 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -479.3 -479302 3.4 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 CBX5 CDC7 SNORD3G ACTBP12 LOC105378852 HFM1 ZNF644 GC01P091527
GH01J091729 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -709.4 -709435 4.6 HDGF FOXA2 PKNOX1 ARNT FEZF1 ZNF2 ZNF766 CBX5 ZNF548 FOS ZNF644 TGFBR3 GC01M091707 GC01M091774
GH01J091872 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.7 -850.5 -850526 0.7 PKNOX1 FOXA2 ZNF133 FEZF1 IRF4 YY1 KLF7 RUNX3 JUNB TSHZ1 GC01M091855 SNORA66 SNORD21 RPL5 ZNF644 GC01P091842 TGFBR3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF644 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF644 gene promoter:
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F
  • Nkx2-2

Genomic Locations for ZNF644 Gene

Genomic Locations for ZNF644 Gene
106,975 bases
Minus strand
106,975 bases
Minus strand

Genomic View for ZNF644 Gene

Genes around ZNF644 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF644 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF644 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF644 Gene

Proteins for ZNF644 Gene

  • Protein details for ZNF644 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 644
    Protein Accession:
    Secondary Accessions:
    • A2RU71
    • Q2TAM0
    • Q5TCC0
    • Q6BEP7
    • Q6P446
    • Q6PI06
    • Q7LG67
    • Q9ULJ9

    Protein attributes for ZNF644 Gene

    1327 amino acids
    Molecular mass:
    149565 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF644 Gene


neXtProt entry for ZNF644 Gene

Post-translational modifications for ZNF644 Gene

  • Ubiquitination at isoforms=21110 and isoforms=2843
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF644 Gene

Domains & Families for ZNF644 Gene

Gene Families for ZNF644 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF644 Gene


Suggested Antigen Peptide Sequences for ZNF644 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF644: view

Function for ZNF644 Gene

Molecular function for ZNF644 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF644 Gene

Gene Ontology (GO) - Molecular Function for ZNF644 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF644: view
genes like me logo Genes that share phenotypes with ZNF644: view

Human Phenotype Ontology for ZNF644 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for ZNF644 Gene

miRTarBase miRNAs that target ZNF644

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF644

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF644 Gene

Localization for ZNF644 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF644 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF644 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF644 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF644: view

Pathways & Interactions for ZNF644 Gene

SuperPathways for ZNF644 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF644 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF644: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF644 Gene

Drugs & Compounds for ZNF644 Gene

No Compound Related Data Available

Transcripts for ZNF644 Gene

Unigene Clusters for ZNF644 Gene

Zinc finger protein 644:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF644

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF644 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2: - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9: - - - - -

Relevant External Links for ZNF644 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF644 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF644 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF644 Gene

This gene is overexpressed in Plasma (23.8), Lung (21.9), and Liver (21.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF644 Gene

Protein tissue co-expression partners for ZNF644 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF644 Gene:


SOURCE GeneReport for Unigene cluster for ZNF644 Gene:


mRNA Expression by UniProt/SwissProt for ZNF644 Gene:

Tissue specificity: Expressed in liver, placenta, retina and retinal pigment epithelium.

Evidence on tissue expression from TISSUES for ZNF644 Gene

  • Nervous system(4.6)
  • Intestine(4.2)
  • Skin(4.2)
  • Eye(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF644 Gene

Germ Layers:
  • ectoderm
  • nervous
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
  • peripheral nervous system
genes like me logo Genes that share expression patterns with ZNF644: view

No data available for mRNA differential expression in normal tissues for ZNF644 Gene

Orthologs for ZNF644 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF644 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF644 34 33
  • 99.45 (n)
(Canis familiaris)
Mammalia ZNF644 34 33
  • 93.44 (n)
(Bos Taurus)
Mammalia ZNF644 34 33
  • 93.42 (n)
(Mus musculus)
Mammalia Zfp644 16 34 33
  • 86.26 (n)
(Rattus norvegicus)
Mammalia Zfp644 33
  • 82.8 (n)
(Ornithorhynchus anatinus)
Mammalia ZNF644 34
  • 80 (a)
(Monodelphis domestica)
Mammalia ZNF644 34
  • 79 (a)
(Gallus gallus)
Aves ZNF644 34 33
  • 80.78 (n)
(Anolis carolinensis)
Reptilia ZNF644 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf644 33
  • 68.43 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8927 33
(Danio rerio)
Actinopterygii znf644b 34
  • 28 (a)
Species where no ortholog for ZNF644 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF644 Gene

Gene Tree for ZNF644 (if available)
Gene Tree for ZNF644 (if available)
Evolutionary constrained regions (ECRs) for ZNF644: view image

Paralogs for ZNF644 Gene

Paralogs for ZNF644 Gene Pseudogenes for ZNF644 Gene

genes like me logo Genes that share paralogs with ZNF644: view

Variants for ZNF644 Gene

Sequence variations from dbSNP and Humsavar for ZNF644 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1050960158 21, autosomal dominant (MYP21) [MIM:614167] 90,938,487(-) G/C coding_sequence_variant, intron_variant, missense_variant
rs143932357 Myopia 21, autosomal dominant (MYP21) [MIM:614167] 90,940,629(-) G/A coding_sequence_variant, intron_variant, missense_variant
rs146936371 pathogenic, Myopia 21, autosomal dominant, Myopia 21, autosomal dominant (MYP21) [MIM:614167] 90,939,595(-) T/C coding_sequence_variant, intron_variant, missense_variant
rs149597385 Myopia 21, autosomal dominant (MYP21) [MIM:614167] 90,940,441(-) C/T coding_sequence_variant, intron_variant, missense_variant
rs193167060 Myopia 21, autosomal dominant (MYP21) [MIM:614167] 90,937,907(-) T/A/C coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF644 Gene

Variant ID Type Subtype PubMed ID
esv3578008 CNV loss 25503493
nsv159370 CNV deletion 16902084
nsv947435 CNV duplication 23825009

Variation tolerance for ZNF644 Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF644 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF644 Gene

Disorders for ZNF644 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ZNF644 Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
myopia 21, autosomal dominant
  • myp21
refractive error
  • refractive errors
degenerative myopia
  • degenerative progressive high myopia
  • near vision
- elite association - COSMIC cancer census association via MalaCards


  • Myopia 21, autosomal dominant (MYP21) [MIM:614167]: A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. {ECO:0000269 PubMed:21695231, ECO:0000269 PubMed:22539872, ECO:0000269 PubMed:24991186, ECO:0000269 PubMed:25525168}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ZNF644

genes like me logo Genes that share disorders with ZNF644: view

No data available for Genatlas for ZNF644 Gene

Publications for ZNF644 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing. (PMID: 25525168) Jiang D … Zhang Q (Investigative ophthalmology & visual science 2014) 3 4 58
  3. New ZNF644 mutations identified in patients with high myopia. (PMID: 24991186) Xiang X … Hu Z (Molecular vision 2014) 3 4 58
  4. Study of a US cohort supports the role of ZNF644 and high-grade myopia susceptibility. (PMID: 22539872) Tran-Viet KN … Young TL (Molecular vision 2012) 3 4 58
  5. Exome sequencing identifies ZNF644 mutations in high myopia. (PMID: 21695231) Shi Y … Yang Z (PLoS genetics 2011) 3 4 58

Products for ZNF644 Gene

Sources for ZNF644 Gene

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