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The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
ZNF644 (Zinc Finger Protein 644) is a Protein Coding gene. Diseases associated with ZNF644 include Myopia 21, Autosomal Dominant and Refractive Error. An important paralog of this gene is ZNF407.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | ||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNF644 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZNF644 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ZNF644 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Zfp644 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zfp644 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF644 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ZNF644 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ZNF644 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ZNF644 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | znf644 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.8927 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | znf644b 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
715422 | Likely Benign: not provided | 90,937,874(-) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
718970 | Likely Benign: not provided | 90,918,075(-) | G/A | SYNONYMOUS_VARIANT | |
721933 | Likely Benign: not provided | 90,941,177(-) | T/C | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
739640 | Benign: not provided | 90,916,849(-) | G/A | SYNONYMOUS_VARIANT | |
749891 | Likely Benign: not provided | 90,940,124(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
myopia 21, autosomal dominant |
|
|
refractive error |
|
|
myopia |
|
|
degenerative myopia |
|
|
deafness and myopia |
|
|