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Aliases for ZNF641 Gene

Aliases for ZNF641 Gene

  • Zinc Finger Protein 641 2 3 4 5

External Ids for ZNF641 Gene

Previous GeneCards Identifiers for ZNF641 Gene

  • GC12M047023
  • GC12M048733
  • GC12M045767

Summaries for ZNF641 Gene

GeneCards Summary for ZNF641 Gene

ZNF641 (Zinc Finger Protein 641) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is PEG3.

UniProtKB/Swiss-Prot for ZNF641 Gene

  • Transcriptional activator. Activates transcriptional activities of SRE and AP-1.

Additional gene information for ZNF641 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF641 Gene

Genomics for ZNF641 Gene

GeneHancer (GH) Regulatory Elements for ZNF641 Gene

Promoters and enhancers for ZNF641 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J048349 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 651.4 +0.4 370 3.5 CC2D1A ZFX CBFA2T2 ZNF148 NKRF MLLT1 CEBPG POLR2A TRIM24 SP7 ZNF641 ENSG00000257735 ENSG00000240399 GC12M048339
GH12J048278 Promoter/Enhancer 1 Ensembl ENCODE 62.8 +71.7 71691 2.2 TCF7L2 CTCF CEBPB NANOG ZNF641 ENSG00000240399 ENSG00000269514 H1FNT ENSG00000258234 LOC105369753 OR10AD1
GH12J048182 Promoter/Enhancer 1.4 Ensembl ENCODE 43.5 +167.8 167813 2.4 CSDE1 SP7 ELF1 CREM IKZF1 CREB1 GLIS2 GMEB1 POLR2A PKNOX1 CCDC184 ZNF641 ENSG00000240399 KMT2D ENSG00000269514 LMBR1L DDX23 KANSL2 LOC390314 ENSG00000279875
GH12J048196 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 28.7 +152.2 152237 4.4 HDGF SP1 ZFX ZKSCAN8 NKRF MLLT1 POLR2A GTF2F1 CSDE1 ZNF687 ENSG00000269514 ZNF641 ENSG00000240399 LMBR1L SENP1 DDX23 ENSG00000268069 LOC390314 ENSG00000258017 KMT2D
GH12J048156 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 17.6 +194.0 193974 2.5 SP1 ZFX ELF3 ZNF148 NKRF POLR2A ZNF687 BACH1 ZBTB7A SP7 ASB8 PFKM ENSG00000240399 ZNF641 H1FNT SENP1 RNU6-1203P CCDC184 TMEM106C ENSG00000258051
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF641 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF641 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Evi-1
  • LCR-F1
  • NF-1
  • RFX1
  • USF-1
  • USF1

Genomic Locations for ZNF641 Gene

Genomic Locations for ZNF641 Gene
chr12:48,335,491-48,351,414
(GRCh38/hg38)
Size:
15,924 bases
Orientation:
Minus strand
chr12:48,733,791-48,745,197
(GRCh37/hg19)
Size:
11,407 bases
Orientation:
Minus strand

Genomic View for ZNF641 Gene

Genes around ZNF641 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF641 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF641 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF641 Gene

Proteins for ZNF641 Gene

  • Protein details for ZNF641 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N77-ZN641_HUMAN
    Recommended name:
    Zinc finger protein 641
    Protein Accession:
    Q96N77
    Secondary Accessions:
    • B3KS43
    • B4DNU5
    • Q8TCQ7
    • Q8WVE1

    Protein attributes for ZNF641 Gene

    Size:
    438 amino acids
    Molecular mass:
    49528 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF641 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF641 Gene

Post-translational modifications for ZNF641 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF641 Gene

Domains & Families for ZNF641 Gene

Gene Families for ZNF641 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF641 Gene

Suggested Antigen Peptide Sequences for ZNF641 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ35421 fis, clone SMINT2001195, highly similar to Homo sapiens zinc finger protein 641 (ZNF641), mRNA (B3KS43_HUMAN)
  • cDNA FLJ58030, highly similar to Homo sapiens zinc finger protein 641 (ZNF641), mRNA (B4DNU5_HUMAN)
  • Zinc finger protein 641 (ZN641_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96N77

UniProtKB/Swiss-Prot:

ZN641_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF641: view

Function for ZNF641 Gene

Molecular function for ZNF641 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator. Activates transcriptional activities of SRE and AP-1.

Phenotypes From GWAS Catalog for ZNF641 Gene

Gene Ontology (GO) - Molecular Function for ZNF641 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF641: view
genes like me logo Genes that share phenotypes with ZNF641: view

Animal Model Products

CRISPR Products

miRNA for ZNF641 Gene

miRTarBase miRNAs that target ZNF641

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF641 - Now 50% OFF >
  • * ZNF641 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF641 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF641 Gene

Localization for ZNF641 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF641 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF641 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF641 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA,IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF641: view

Pathways & Interactions for ZNF641 Gene

genes like me logo Genes that share pathways with ZNF641: view

Pathways by source for ZNF641 Gene

2 Reactome pathways for ZNF641 Gene
1 KEGG pathway for ZNF641 Gene

Interacting Proteins for ZNF641 Gene

Gene Ontology (GO) - Biological Process for ZNF641 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF641: view

No data available for SIGNOR curated interactions for ZNF641 Gene

Drugs & Compounds for ZNF641 Gene

No Compound Related Data Available

Transcripts for ZNF641 Gene

mRNA/cDNA for ZNF641 Gene

Unigene Clusters for ZNF641 Gene

Zinc finger protein 641:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF641 - Now 50% OFF >
  • * ZNF641 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF641 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF641 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: -
SP7:
SP8:

Relevant External Links for ZNF641 Gene

GeneLoc Exon Structure for
ZNF641
ECgene alternative splicing isoforms for
ZNF641

Expression for ZNF641 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF641 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF641 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF641 Gene



Protein tissue co-expression partners for ZNF641 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF641 Gene:

ZNF641

SOURCE GeneReport for Unigene cluster for ZNF641 Gene:

Hs.23492

mRNA Expression by UniProt/SwissProt for ZNF641 Gene:

Q96N77-ZN641_HUMAN
Tissue specificity: Highly expressed in skeletal muscle, moderate expression in heart, liver, and pancreas, lower expression in placenta, no expression seen in brain, lung, and kidney.

Evidence on tissue expression from TISSUES for ZNF641 Gene

  • Nervous system(4.5)
  • Heart(4.3)
  • Kidney(4.3)
  • Intestine(4.2)
  • Lung(4.2)
  • Lymph node(4.2)
genes like me logo Genes that share expression patterns with ZNF641: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF641 Gene

Orthologs for ZNF641 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF641 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF641 35 34
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF641 35 34
  • 93.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF641 35 34
  • 92.53 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp641 34
  • 85.27 (n)
mouse
(Mus musculus)
Mammalia Zfp641 17 35 34
  • 84.44 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF641 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF641 35
  • 41 (a)
OneToOne
Species where no ortholog for ZNF641 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF641 Gene

ENSEMBL:
Gene Tree for ZNF641 (if available)
TreeFam:
Gene Tree for ZNF641 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF641: view image

Paralogs for ZNF641 Gene

genes like me logo Genes that share paralogs with ZNF641: view

Variants for ZNF641 Gene

Sequence variations from dbSNP and Humsavar for ZNF641 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000047341 -- 48,337,407(-) G/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000284313 -- 48,350,934(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000402264 -- 48,344,173(-) C/T intron_variant
rs1000700910 -- 48,345,618(-) A/G intron_variant
rs1000849780 -- 48,344,970(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF641 Gene

Variant ID Type Subtype PubMed ID
esv2759898 CNV gain+loss 17122850
esv34439 CNV gain 17911159
esv3629436 CNV gain 21293372
nsv1044444 CNV loss 25217958
nsv1045159 CNV gain 25217958
nsv437752 CNV loss 16327808
nsv438208 CNV loss 16468122
nsv826362 CNV gain 20364138
nsv832402 CNV gain 17160897
nsv8971 CNV gain+loss 18304495

Variation tolerance for ZNF641 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.68; 82.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF641 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF641

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF641 Gene

Disorders for ZNF641 Gene

Additional Disease Information for ZNF641

No disorders were found for ZNF641 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF641 Gene

Publications for ZNF641 Gene

  1. Activation of transcriptional activities of AP-1 and SRE by a new zinc-finger protein ZNF641. (PMID: 16343441) Qi X … Wu X (Biochemical and biophysical research communications 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 58
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  5. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. (PMID: 21244100) Virok DP … Fülöp L (Journal of proteome research 2011) 3 58

Products for ZNF641 Gene

Sources for ZNF641 Gene

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