This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSe... See more...

Aliases for ZNF639 Gene

Aliases for ZNF639 Gene

  • Zinc Finger Protein 639 2 3 4 5
  • ZASC1 2 3 4
  • Zinc Finger Amplified In Esophageal Squamous Cell Carcinomas 1 2 3
  • ANC-2H01 2 3
  • Zinc Finger Protein ANC_2H01 4
  • Zinc Finger Protein ZASC1 4
  • ANC_2H01 3
  • ZNF639 5

External Ids for ZNF639 Gene

Previous GeneCards Identifiers for ZNF639 Gene

  • GC03P180524
  • GC03P179040
  • GC03P176444

Summaries for ZNF639 Gene

Entrez Gene Summary for ZNF639 Gene

  • This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for ZNF639 Gene

ZNF639 (Zinc Finger Protein 639) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is IKZF4.

UniProtKB/Swiss-Prot Summary for ZNF639 Gene

Additional gene information for ZNF639 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF639 Gene

Genomics for ZNF639 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF639 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF639 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF639

Top Transcription factor binding sites by QIAGEN in the ZNF639 gene promoter:
  • C/EBPbeta
  • Cdc5
  • CREB
  • deltaCREB
  • FOXJ2
  • FOXJ2 (long isoform)
  • HNF-4alpha1
  • HNF-4alpha2
  • LCR-F1
  • Nkx6-1

Genomic Locations for ZNF639 Gene

Genomic Locations for ZNF639 Gene
chr3:179,322,876-179,338,583
(GRCh38/hg38)
Size:
15,708 bases
Orientation:
Plus strand
chr3:179,040,779-179,053,323
(GRCh37/hg19)
Size:
12,545 bases
Orientation:
Plus strand

Genomic View for ZNF639 Gene

Genes around ZNF639 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF639 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF639 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF639 Gene

Proteins for ZNF639 Gene

  • Protein details for ZNF639 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UID6-ZN639_HUMAN
    Recommended name:
    Zinc finger protein 639
    Protein Accession:
    Q9UID6
    Secondary Accessions:
    • A9X3Z9
    • D3DNR3

    Protein attributes for ZNF639 Gene

    Size:
    485 amino acids
    Molecular mass:
    56054 Da
    Quaternary structure:
    • Interacts with CTNNA2.

neXtProt entry for ZNF639 Gene

Post-translational modifications for ZNF639 Gene

  • Ubiquitination at Lys263
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF639 Gene

Domains & Families for ZNF639 Gene

Gene Families for ZNF639 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF639 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF639 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein ZASC1 (ZN639_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UID6

UniProtKB/Swiss-Prot:

ZN639_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF639: view

Function for ZNF639 Gene

Molecular function for ZNF639 Gene

UniProtKB/Swiss-Prot Function:
Binds DNA and may function as a transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF639 Gene

Gene Ontology (GO) - Molecular Function for ZNF639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA, IBA 20484494
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 20484494
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 20484494
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZNF639: view
genes like me logo Genes that share phenotypes with ZNF639: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF639

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF639 Gene

Localization for ZNF639 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF639 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF639 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 14522885
GO:0005654 nucleoplasm IBA,IDA --
genes like me logo Genes that share ontologies with ZNF639: view

Pathways & Interactions for ZNF639 Gene

PathCards logo

SuperPathways for ZNF639 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030307 positive regulation of cell growth IMP 14522885
GO:0043922 negative regulation by host of viral transcription IMP 20484494
GO:0043923 positive regulation by host of viral transcription IMP 20484494
GO:0045892 negative regulation of transcription, DNA-templated IDA 16182284
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 20484494
genes like me logo Genes that share ontologies with ZNF639: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF639 Gene

Drugs & Compounds for ZNF639 Gene

No Compound Related Data Available

Transcripts for ZNF639 Gene

mRNA/cDNA for ZNF639 Gene

10 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF639

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF639 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for ZNF639 Gene

GeneLoc Exon Structure for
ZNF639

Expression for ZNF639 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF639 Gene

Protein differential expression in normal tissues from HIPED for ZNF639 Gene

This gene is overexpressed in Breast (31.2), Adipocyte (17.7), and CD8 Tcells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF639 Gene



Protein tissue co-expression partners for ZNF639 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF639

SOURCE GeneReport for Unigene cluster for ZNF639 Gene:

Hs.632578

Evidence on tissue expression from TISSUES for ZNF639 Gene

  • Kidney(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF639: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF639 Gene

Orthologs for ZNF639 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF639 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF639 30 31
  • 99.38 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF639 30 31
  • 95.19 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF639 30 31
  • 95.05 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp639 30
  • 87.49 (n)
Mouse
(Mus musculus)
Mammalia Zfp639 30 17 31
  • 87.01 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF639 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF639 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF639 30 31
  • 72.14 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZNF639 31
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia znf639 30
  • 68.97 (n)
Str.19246 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.5624 30
Species where no ortholog for ZNF639 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF639 Gene

ENSEMBL:
Gene Tree for ZNF639 (if available)
TreeFam:
Gene Tree for ZNF639 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF639: view image

Paralogs for ZNF639 Gene

genes like me logo Genes that share paralogs with ZNF639: view

Variants for ZNF639 Gene

Additional dbSNP identifiers (rs#s) for ZNF639 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF639 Gene

Variant ID Type Subtype PubMed ID
dgv4999n100 CNV gain 25217958
nsv1010137 CNV gain 25217958
nsv1123711 CNV deletion 24896259
nsv471116 CNV gain 18288195
nsv592650 CNV gain 21841781
nsv829806 CNV gain 17160897

Variation tolerance for ZNF639 Gene

Residual Variation Intolerance Score: 12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF639 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF639

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF639 Gene

Disorders for ZNF639 Gene

Additional Disease Information for ZNF639

No disorders were found for ZNF639 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF639 Gene

Publications for ZNF639 Gene

  1. Identification of ZASC1 encoding a Krüppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas. (PMID: 14522885) Imoto I … Inazawa J (Cancer research 2003) 2 3 4
  2. Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. (PMID: 16182284) Bogaerts S … van Roy F (Experimental cell research 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3

Products for ZNF639 Gene

Sources for ZNF639 Gene