This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSe... See more...

Aliases for ZNF639 Gene

Aliases for ZNF639 Gene

  • Zinc Finger Protein 639 2 3 4 5
  • Zinc Finger Amplified In Esophageal Squamous Cell Carcinomas 1 2 3
  • ZASC1 3 4
  • Zinc Finger Protein ANC_2H01 4
  • Zinc Finger Protein ZASC1 4
  • ANC-2H01 3
  • ANC_2H01 3

External Ids for ZNF639 Gene

Previous GeneCards Identifiers for ZNF639 Gene

  • GC03P180524
  • GC03P179040
  • GC03P176444

Summaries for ZNF639 Gene

Entrez Gene Summary for ZNF639 Gene

  • This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for ZNF639 Gene

ZNF639 (Zinc Finger Protein 639) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is ZNF613.

UniProtKB/Swiss-Prot Summary for ZNF639 Gene

Additional gene information for ZNF639 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF639 Gene

Genomics for ZNF639 Gene

GeneHancer (GH) Regulatory Elements for ZNF639 Gene

Promoters and enhancers for ZNF639 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J179321 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 775.4 +0.3 330 4.6 ZNF24 SP1 ZBTB40 CTCF SIX5 SMARCE1 RBPJ POLR2A HCFC1 MYC ZNF639 MFN1 ENSG00000242539 LOC101928739 PIK3CA HSALNG0030960
GH03J179346 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 18.7 +25.0 24985 3.6 ZNF24 ZBTB40 SIX5 ZBTB6 POLR2A ATF1 CREB1 HCFC1 MIXL1 ZNF362 MFN1 ZNF639 ENSG00000242539
GH03J179261 Promoter 1.2 EPDnew Ensembl 22 -64.0 -63989 2 CC2D1A L3MBTL2 MLLT1 PRDM1 TRIM24 GMEB1 IKZF1 ZBTB33 CREB1 PRDM10 KCNMB3 PIK3CA ZNF639 LOC101928739 MFN1 LRRFIP1P1 lnc-GNB4-2
GH03J179069 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.8 -252.6 -252577 4.4 SP1 CTCF POLR2A HDAC2 MYC ETV6 ELF1 RELA L3MBTL2 MAX ZMAT3 LOC101928739 PIK3CA ZNF639 piR-33905-062
GH03J179146 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 13.6 -174.3 -174290 4.6 SIN3A ZBTB40 CTCF GATA3 SIX5 SMARCE1 POLR2A ATF1 CREB1 HCFC1 PIK3CA LOC101928739 ZNF639 ENSG00000242539 LN626315
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF639 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF639 gene promoter:
  • C/EBPbeta
  • Cdc5
  • CREB
  • deltaCREB
  • FOXJ2
  • FOXJ2 (long isoform)
  • HNF-4alpha1
  • HNF-4alpha2
  • LCR-F1
  • Nkx6-1

Genomic Locations for ZNF639 Gene

Genomic Locations for ZNF639 Gene
chr3:179,322,991-179,338,583
(GRCh38/hg38)
Size:
15,593 bases
Orientation:
Plus strand
chr3:179,040,779-179,053,323
(GRCh37/hg19)
Size:
12,545 bases
Orientation:
Plus strand

Genomic View for ZNF639 Gene

Genes around ZNF639 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF639 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF639 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF639 Gene

Proteins for ZNF639 Gene

  • Protein details for ZNF639 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UID6-ZN639_HUMAN
    Recommended name:
    Zinc finger protein 639
    Protein Accession:
    Q9UID6
    Secondary Accessions:
    • A9X3Z9
    • D3DNR3

    Protein attributes for ZNF639 Gene

    Size:
    485 amino acids
    Molecular mass:
    56054 Da
    Quaternary structure:
    • Interacts with CTNNA2.

neXtProt entry for ZNF639 Gene

Post-translational modifications for ZNF639 Gene

  • Ubiquitination at Lys263
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF639 Gene

Domains & Families for ZNF639 Gene

Gene Families for ZNF639 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF639 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF639 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein ZASC1 (ZN639_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UID6

UniProtKB/Swiss-Prot:

ZN639_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF639: view

Function for ZNF639 Gene

Molecular function for ZNF639 Gene

UniProtKB/Swiss-Prot Function:
Binds DNA and may function as a transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF639 Gene

Gene Ontology (GO) - Molecular Function for ZNF639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 20484494
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 20484494
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZNF639: view
genes like me logo Genes that share phenotypes with ZNF639: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF639

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF639 Gene

Localization for ZNF639 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF639 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF639 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 14522885
GO:0005654 nucleoplasm IDA,IBA --
genes like me logo Genes that share ontologies with ZNF639: view

Pathways & Interactions for ZNF639 Gene

PathCards logo

SuperPathways for ZNF639 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030307 positive regulation of cell growth IMP 14522885
GO:0043922 negative regulation by host of viral transcription IMP 20484494
GO:0043923 positive regulation by host of viral transcription IMP 20484494
GO:0045892 negative regulation of transcription, DNA-templated IDA 16182284
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 20484494
genes like me logo Genes that share ontologies with ZNF639: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF639 Gene

Drugs & Compounds for ZNF639 Gene

No Compound Related Data Available

Transcripts for ZNF639 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF639

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF639 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for ZNF639 Gene

GeneLoc Exon Structure for
ZNF639
ECgene alternative splicing isoforms for
ZNF639

Expression for ZNF639 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF639 Gene

Protein differential expression in normal tissues from HIPED for ZNF639 Gene

This gene is overexpressed in Breast (31.2), Adipocyte (17.7), and CD8 Tcells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF639 Gene



Protein tissue co-expression partners for ZNF639 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF639 Gene:

ZNF639

SOURCE GeneReport for Unigene cluster for ZNF639 Gene:

Hs.632578

Evidence on tissue expression from TISSUES for ZNF639 Gene

  • Kidney(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF639: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF639 Gene

Orthologs for ZNF639 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF639 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF639 33 32
  • 99.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF639 33 32
  • 95.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF639 33 32
  • 95.05 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp639 32
  • 87.49 (n)
mouse
(Mus musculus)
Mammalia Zfp639 17 33 32
  • 87.01 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF639 33
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF639 33
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF639 33 32
  • 72.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF639 33
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf639 32
  • 68.97 (n)
Str.19246 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.5624 32
Species where no ortholog for ZNF639 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF639 Gene

ENSEMBL:
Gene Tree for ZNF639 (if available)
TreeFam:
Gene Tree for ZNF639 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF639: view image

Paralogs for ZNF639 Gene

genes like me logo Genes that share paralogs with ZNF639: view

Variants for ZNF639 Gene

Sequence variations from dbSNP and Humsavar for ZNF639 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000181287 -- 179,327,958(+) T/C/G intron_variant
rs1000412720 -- 179,327,198(+) A/G intron_variant
rs1000465009 -- 179,326,961(+) GGG/G intron_variant
rs1000630852 -- 179,332,932(+) A/G intron_variant
rs1000661897 -- 179,332,503(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF639 Gene

Variant ID Type Subtype PubMed ID
dgv4999n100 CNV gain 25217958
nsv1010137 CNV gain 25217958
nsv1123711 CNV deletion 24896259
nsv471116 CNV gain 18288195
nsv592650 CNV gain 21841781
nsv829806 CNV gain 17160897

Variation tolerance for ZNF639 Gene

Residual Variation Intolerance Score: 12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF639 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF639

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF639 Gene

Disorders for ZNF639 Gene

Additional Disease Information for ZNF639

No disorders were found for ZNF639 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF639 Gene

Publications for ZNF639 Gene

  1. Identification of ZASC1 encoding a Krüppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas. (PMID: 14522885) Imoto I … Inazawa J (Cancer research 2003) 2 3 4 56
  2. Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. (PMID: 16182284) Bogaerts S … van Roy F (Experimental cell research 2005) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 56

Products for ZNF639 Gene

Sources for ZNF639 Gene