The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological valid... See more...

Aliases for ZNF638 Gene

Aliases for ZNF638 Gene

  • Zinc Finger Protein 638 2 3 4 5
  • Cutaneous T-Cell Lymphoma-Associated Antigen Se33-1 3 4
  • Zinc Finger Matrin-Like Protein 3 4
  • CTCL-Associated Antigen Se33-1 3 4
  • Nuclear Protein 220 3 4
  • NP220 3 4
  • ZFML 3 4
  • CTCL Tumor Antigen Se33-1 3
  • Zinc Finger, Matrin-Like 2
  • NP220 Nuclear Protein 3
  • Zfp638 3

External Ids for ZNF638 Gene

Previous HGNC Symbols for ZNF638 Gene

  • ZFML

Previous GeneCards Identifiers for ZNF638 Gene

  • GC02P071470
  • GC02P071357
  • GC02P071412

Summaries for ZNF638 Gene

Entrez Gene Summary for ZNF638 Gene

  • The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF638 Gene

ZNF638 (Zinc Finger Protein 638) is a Protein Coding gene. Diseases associated with ZNF638 include Cutaneous T Cell Lymphoma. Among its related pathways are Developmental Biology and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MATR3.

UniProtKB/Swiss-Prot Summary for ZNF638 Gene

  • Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:8647861, PubMed:30487602). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity).

Gene Wiki entry for ZNF638 Gene

Additional gene information for ZNF638 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF638 Gene

Genomics for ZNF638 Gene

GeneHancer (GH) Regulatory Elements for ZNF638 Gene

Promoters and enhancers for ZNF638 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF638 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF638 gene promoter:
  • AREB6
  • C/EBPalpha
  • Cart-1
  • En-1
  • NF-kappaB
  • Pax-5
  • Roaz
  • Sox5
  • TGIF

Genomic Locations for ZNF638 Gene

Genomic Locations for ZNF638 Gene
chr2:71,276,561-71,435,069
(GRCh38/hg38)
Size:
158,509 bases
Orientation:
Plus strand
chr2:71,503,691-71,662,199
(GRCh37/hg19)
Size:
158,509 bases
Orientation:
Plus strand

Genomic View for ZNF638 Gene

Genes around ZNF638 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF638 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF638 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF638 Gene

Proteins for ZNF638 Gene

  • Protein details for ZNF638 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14966-ZN638_HUMAN
    Recommended name:
    Zinc finger protein 638
    Protein Accession:
    Q14966
    Secondary Accessions:
    • A0A096LPH6
    • B5MDV1
    • B7ZLD1
    • Q53R34
    • Q5XJ05
    • Q68DP3
    • Q6P2H2
    • Q7Z3T7
    • Q8NF92
    • Q8TCA1
    • Q9H2G1
    • Q9NP37

    Protein attributes for ZNF638 Gene

    Size:
    1978 amino acids
    Molecular mass:
    220625 Da
    Quaternary structure:
    • Interacts with FHL2 (PubMed:11813260). Interacts with CEBPA, CEBPD and CEBPG (By similarity). Interacts with MPHOSPH8 and TASOR components of the HUSH complex; leading to recruitment of the HUSH complex (PubMed:30487602). Interacts with SETDB1 (PubMed:30487602). Interacts with HDAC1 (PubMed:30487602). Interacts with HDAC4 (PubMed:30487602).
    Miscellaneous:
    • Isoform 5: Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.
    SequenceCaution:
    • Sequence=AAH64530.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF638 Gene

neXtProt entry for ZNF638 Gene

Post-translational modifications for ZNF638 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF638 Gene

Domains & Families for ZNF638 Gene

Gene Families for ZNF638 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ZNF638 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 638, isoform CRA_c (D6W5H1_HUMAN)
  • Zinc finger matrin-like protein (ZN638_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14966

UniProtKB/Swiss-Prot:

ZN638_HUMAN :
  • The matrin-type zinc finger domain is required for localization to nuclear speckles.
Domain:
  • The matrin-type zinc finger domain is required for localization to nuclear speckles.
genes like me logo Genes that share domains with ZNF638: view

Function for ZNF638 Gene

Molecular function for ZNF638 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:8647861, PubMed:30487602). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity).

Phenotypes From GWAS Catalog for ZNF638 Gene

Gene Ontology (GO) - Molecular Function for ZNF638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding TAS 8647861
GO:0003723 RNA binding HDA,TAS 22658674
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF638: view
genes like me logo Genes that share phenotypes with ZNF638: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF638

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF638 Gene

Localization for ZNF638 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF638 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF638 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm TAS 8647861
GO:0016607 nuclear speck IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ZNF638: view

Pathways & Interactions for ZNF638 Gene

genes like me logo Genes that share pathways with ZNF638: view

Pathways by source for ZNF638 Gene

Gene Ontology (GO) - Biological Process for ZNF638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with ZNF638: view

No data available for SIGNOR curated interactions for ZNF638 Gene

Drugs & Compounds for ZNF638 Gene

(1) Drugs for ZNF638 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytarabine Approved, Experimental, Investigational Pharma 1294
genes like me logo Genes that share compounds with ZNF638: view

Transcripts for ZNF638 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF638

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF638 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1:
SP2:
SP3:
SP4:
SP5: - -
SP6: -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ZNF638 Gene

GeneLoc Exon Structure for
ZNF638
ECgene alternative splicing isoforms for
ZNF638

Expression for ZNF638 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF638 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF638 Gene

This gene is overexpressed in Fetal Brain (13.9), Peripheral blood mononuclear cells (12.1), and Pancreas (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF638 Gene



Protein tissue co-expression partners for ZNF638 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF638 Gene:

ZNF638

SOURCE GeneReport for Unigene cluster for ZNF638 Gene:

Hs.434401

Evidence on tissue expression from TISSUES for ZNF638 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with ZNF638: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF638 Gene

Orthologs for ZNF638 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF638 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF638 33 32
  • 99.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF638 33 32
  • 90.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF638 33 32
  • 89.61 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp638 32
  • 85.45 (n)
mouse
(Mus musculus)
Mammalia Zfml 33 32
  • 85.12 (n)
OneToOne
Zfp638 17
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 75 (a)
OneToMany
-- 33
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 47 (a)
OneToMany
-- 33
  • 43 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZNF638 33
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF638 33
  • 38 (a)
OneToOne
Species where no ortholog for ZNF638 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF638 Gene

ENSEMBL:
Gene Tree for ZNF638 (if available)
TreeFam:
Gene Tree for ZNF638 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF638: view image

Paralogs for ZNF638 Gene

Paralogs for ZNF638 Gene

(1) SIMAP similar genes for ZNF638 Gene using alignment to 8 proteins:

  • ZN638_HUMAN
  • C9JHV0_HUMAN
  • C9JMR2_HUMAN
  • C9JSD0_HUMAN
  • C9JWN0_HUMAN
  • D6W5H1_HUMAN
  • E7EUZ3_HUMAN
  • M0QXP4_HUMAN
genes like me logo Genes that share paralogs with ZNF638: view

Variants for ZNF638 Gene

Sequence variations from dbSNP and Humsavar for ZNF638 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000000668 -- 71,430,891(+) T/A/C intron_variant
rs1000035970 -- 71,345,380(+) C/T intron_variant
rs1000040887 -- 71,389,348(+) T/A intron_variant
rs1000056331 -- 71,384,261(+) T/C intron_variant
rs1000107526 -- 71,346,745(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF638 Gene

Variant ID Type Subtype PubMed ID
dgv3863n100 CNV gain 25217958
dgv3864n100 CNV loss 25217958
esv3591226 CNV gain 21293372
esv3591228 CNV gain 21293372
nsv1010266 CNV gain 25217958
nsv1117243 CNV tandem duplication 24896259
nsv1125212 CNV insertion 24896259
nsv1146116 CNV insertion 26484159
nsv519545 CNV loss 19592680
nsv521345 CNV loss 19592680
nsv526102 CNV gain 19592680

Variation tolerance for ZNF638 Gene

Residual Variation Intolerance Score: 2.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.31; 96.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF638 Gene

Human Gene Mutation Database (HGMD)
ZNF638
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF638

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF638 Gene

Disorders for ZNF638 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF638 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF638

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF638: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF638 Gene

Publications for ZNF638 Gene

  1. A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain. (PMID: 8647861) Inagaki H … Kitagawa Y (The Journal of biological chemistry 1996) 2 3 4 23 56
  2. NP220 mediates silencing of unintegrated retroviral DNA. (PMID: 30487602) Zhu Y … Goff SP (Nature 2018) 3 4 56
  3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 43 56
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 56
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 56

Products for ZNF638 Gene

  • Boster Bio Antibodies for ZNF638
  • Boster Bio ELISA Kits for ZNF638

Sources for ZNF638 Gene