Aliases for ZNF629 Gene

Aliases for ZNF629 Gene

  • Zinc Finger Protein 629 2 3 4 5
  • Zinc Finger Protein 65 2 3 4
  • KIAA0326 2 4
  • ZNF65 3 4
  • DNA-Binding Protein 3
  • ZNF629 5
  • ZNF 3

External Ids for ZNF629 Gene

Previous HGNC Symbols for ZNF629 Gene

  • ZNF65

Previous GeneCards Identifiers for ZNF629 Gene

  • GC16M030830
  • GC16M030700
  • GC16M030697
  • GC16M028352

Summaries for ZNF629 Gene

GeneCards Summary for ZNF629 Gene

ZNF629 (Zinc Finger Protein 629) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF624.

UniProtKB/Swiss-Prot Summary for ZNF629 Gene

Additional gene information for ZNF629 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF629 Gene

Genomics for ZNF629 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF629 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF629 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF629

Top Transcription factor binding sites by QIAGEN in the ZNF629 gene promoter:
  • Bach2
  • HEN1
  • LCR-F1
  • MRF-2
  • NF-E2
  • NF-E2 p45
  • Olf-1
  • RORalpha1

Genomic Locations for ZNF629 Gene

Genomic Locations for ZNF629 Gene
8,750 bases
Minus strand
8,754 bases
Minus strand

Genomic View for ZNF629 Gene

Genes around ZNF629 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF629 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF629 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF629 Gene

Proteins for ZNF629 Gene

  • Protein details for ZNF629 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 629
    Protein Accession:
    Secondary Accessions:
    • Q15938

    Protein attributes for ZNF629 Gene

    869 amino acids
    Molecular mass:
    96620 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA20784.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF629 Gene

Post-translational modifications for ZNF629 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF629 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF629 Gene

Domains & Families for ZNF629 Gene

Gene Families for ZNF629 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF629 Gene


Suggested Antigen Peptide Sequences for ZNF629 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 65 (ZN629_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF629: view

Function for ZNF629 Gene

Molecular function for ZNF629 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF629 Gene

Gene Ontology (GO) - Molecular Function for ZNF629 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF629: view
genes like me logo Genes that share phenotypes with ZNF629: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF629

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF629 Gene

Localization for ZNF629 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF629 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF629 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
golgi apparatus 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF629 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF629: view

Pathways & Interactions for ZNF629 Gene

PathCards logo

SuperPathways for ZNF629 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF629 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF629 Gene

Drugs & Compounds for ZNF629 Gene

No Compound Related Data Available

Transcripts for ZNF629 Gene

mRNA/cDNA for ZNF629 Gene

9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF629

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF629 Gene

No ASD Table

Relevant External Links for ZNF629 Gene

GeneLoc Exon Structure for

Expression for ZNF629 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF629 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF629 Gene

This gene is overexpressed in Platelet (25.7), Fetal Brain (22.6), and Retina (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF629 Gene

Protein tissue co-expression partners for ZNF629 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF629

SOURCE GeneReport for Unigene cluster for ZNF629 Gene:


Evidence on tissue expression from TISSUES for ZNF629 Gene

  • Nervous system(4.6)
  • Liver(4.5)
  • Skin(2.4)
  • Kidney(2.4)
  • Blood(2.3)
  • Muscle(2.1)
  • Heart(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with ZNF629: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF629 Gene

Orthologs for ZNF629 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF629 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF629 30 31
  • 99.58 (n)
(Canis familiaris)
Mammalia ZNF629 30 31
  • 90.28 (n)
(Bos Taurus)
Mammalia ZNF629 30 31
  • 90.25 (n)
(Mus musculus)
Mammalia Zfp629 30 17 31
  • 86.08 (n)
(Rattus norvegicus)
Mammalia Zfp629 30
  • 85.99 (n)
(Monodelphis domestica)
Mammalia ZNF629 31
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF629 31
  • 72 (a)
(Gallus gallus)
Aves -- 31
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 49 (a)
-- 31
  • 48 (a)
-- 31
  • 42 (a)
-- 31
  • 40 (a)
-- 31
  • 39 (a)
-- 31
  • 39 (a)
-- 31
  • 38 (a)
-- 31
  • 38 (a)
-- 31
  • 37 (a)
-- 31
  • 34 (a)
-- 31
  • 33 (a)
-- 31
  • 27 (a)
(Danio rerio)
Actinopterygii si:zfos-44a5.2 31
  • 45 (a)
BX640537.2 31
  • 41 (a)
AL954741.1 31
  • 40 (a)
CABZ01006831.1 31
  • 39 (a)
CU672268.1 31
  • 38 (a)
CABZ01006835.1 31
  • 38 (a)
zgc:174712 31
  • 37 (a)
CABZ01075191.1 31
  • 36 (a)
si:dkey-20i20.5 31
  • 36 (a)
si:ch211-235i11.2 31
  • 34 (a)
CABZ01048402.1 31
  • 33 (a)
BX000701.1 31
  • 32 (a)
zgc:113389 31
  • 31 (a)
FP326649.1 31
  • 30 (a)
Species where no ortholog for ZNF629 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF629 Gene

Gene Tree for ZNF629 (if available)
Gene Tree for ZNF629 (if available)
Evolutionary constrained regions (ECRs) for ZNF629: view image

Paralogs for ZNF629 Gene

Paralogs for ZNF629 Gene

(476) SIMAP similar genes for ZNF629 Gene using alignment to 1 proteins:

  • ZN629_HUMAN
genes like me logo Genes that share paralogs with ZNF629: view

Variants for ZNF629 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF629 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
724646 Benign: not provided 30,784,153(-) T/A MISSENSE_VARIANT
777007 Benign: not provided 30,781,848(-) T/A MISSENSE_VARIANT
rs8050758 - p.Pro707Ala

Additional dbSNP identifiers (rs#s) for ZNF629 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF629 Gene

Variant ID Type Subtype PubMed ID
nsv469724 CNV loss 16826518
nsv833188 CNV loss 17160897
nsv9438 CNV gain 18304495

Variation tolerance for ZNF629 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF629 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF629 Gene

Disorders for ZNF629 Gene

No disorders were found for ZNF629 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF629 Gene

Publications for ZNF629 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4
  2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 3 4
  3. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P … Dawid IB (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3

Products for ZNF629 Gene

Sources for ZNF629 Gene