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Aliases for ZNF629 Gene

Aliases for ZNF629 Gene

  • Zinc Finger Protein 629 2 3 4 5
  • Zinc Finger Protein 65 2 3 4
  • ZNF65 3 4
  • DNA-Binding Protein 3
  • KIAA0326 4
  • ZNF 3

External Ids for ZNF629 Gene

Previous HGNC Symbols for ZNF629 Gene

  • ZNF65

Previous GeneCards Identifiers for ZNF629 Gene

  • GC16M030830
  • GC16M030700
  • GC16M030697
  • GC16M028352

Summaries for ZNF629 Gene

GeneCards Summary for ZNF629 Gene

ZNF629 (Zinc Finger Protein 629) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF624.

UniProtKB/Swiss-Prot for ZNF629 Gene

Additional gene information for ZNF629 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF629 Gene

Genomics for ZNF629 Gene

GeneHancer (GH) Regulatory Elements for ZNF629 Gene

Promoters and enhancers for ZNF629 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J030785 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 600.7 +0.5 539 3.4 ZNF652 ZFX SP1 CC2D1A ELF3 ZNF148 MLLT1 ZSCAN21 NFRKB AHR ZNF629 SRCAP SETD1A ENSG00000260267 INO80E SMG1P5 ENSG00000260304 ZNF764 NPIPB13 RNF40
GH16J030566 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.7 +217.3 217343 6.1 HDGF CC2D1A SP1 ZFX ELF3 MNT SIX5 ZNF148 NKRF ZNF121 ZNF688 SETD1A SRCAP ENSG00000260267 NPIPB13 ZNF747 INO80E ZNF764 C16orf58 SMG1P5
GH16J030051 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.1 +733.9 733861 4.6 MTA3 CC2D1A ZFX SP1 ELF3 CTCF MNT NKRF ZNF121 CEBPG ALDOA LOC112694756 TLCD3B SETD1A SRCAP NPIPB12 INO80E ZNF764 NPIPB13 ZNF747
GH16J029942 Enhancer 1.3 FANTOM5 ENCODE 32.9 +843.3 843295 3.7 MTA3 ZFX CC2D1A ELF3 ZKSCAN8 CBFA2T2 MLLT1 ZNF121 GTF2F1 ZNF384 SRCAP INO80E ENSG00000260853 ZNF785 SPNS1 NPIPB12 ENSG00000260367 NFATC2IP SMG1P5 SMG1P2
GH16J029992 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.7 +792.3 792311 4.9 ZNF473 HDGF MTA3 SP1 ZFX ELF3 ZKSCAN8 MNT SIX5 NKRF INO80E GC16M029996 HIRIP3 PIR46286 PIR37996 SRCAP SMG1P5 SETD1A SMG1P2 ENSG00000198106
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF629 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF629 gene promoter:
  • Bach2
  • HEN1
  • LCR-F1
  • MRF-2
  • NF-E2
  • NF-E2 p45
  • Olf-1
  • RORalpha1

Genomic Locations for ZNF629 Gene

Genomic Locations for ZNF629 Gene
chr16:30,778,449-30,787,277
(GRCh38/hg38)
Size:
8,829 bases
Orientation:
Minus strand
chr16:30,789,770-30,798,523
(GRCh37/hg19)
Size:
8,754 bases
Orientation:
Minus strand

Genomic View for ZNF629 Gene

Genes around ZNF629 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF629 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF629 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF629 Gene

Proteins for ZNF629 Gene

  • Protein details for ZNF629 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UEG4-ZN629_HUMAN
    Recommended name:
    Zinc finger protein 629
    Protein Accession:
    Q9UEG4
    Secondary Accessions:
    • Q15938

    Protein attributes for ZNF629 Gene

    Size:
    869 amino acids
    Molecular mass:
    96620 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20784.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF629 Gene

Post-translational modifications for ZNF629 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF629 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF629 Gene

Domains & Families for ZNF629 Gene

Gene Families for ZNF629 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF629 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF629 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 65 (ZN629_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UEG4

UniProtKB/Swiss-Prot:

ZN629_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF629: view

Function for ZNF629 Gene

Molecular function for ZNF629 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF629 Gene

Gene Ontology (GO) - Molecular Function for ZNF629 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF629: view
genes like me logo Genes that share phenotypes with ZNF629: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF629

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF629 Gene

Localization for ZNF629 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF629 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF629 gene
Compartment Confidence
nucleus 5
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF629 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF629: view

Pathways & Interactions for ZNF629 Gene

PathCards logo

SuperPathways for ZNF629 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF629 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF629: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF629 Gene

Drugs & Compounds for ZNF629 Gene

No Compound Related Data Available

Transcripts for ZNF629 Gene

mRNA/cDNA for ZNF629 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(111) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZNF629 Gene

Zinc finger protein 629:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF629

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF629 Gene

No ASD Table

Relevant External Links for ZNF629 Gene

GeneLoc Exon Structure for
ZNF629
ECgene alternative splicing isoforms for
ZNF629

Expression for ZNF629 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF629 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF629 Gene

This gene is overexpressed in Platelet (25.7), Fetal Brain (22.6), and Retina (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF629 Gene



Protein tissue co-expression partners for ZNF629 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF629 Gene:

ZNF629

SOURCE GeneReport for Unigene cluster for ZNF629 Gene:

Hs.301094

Evidence on tissue expression from TISSUES for ZNF629 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZNF629: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF629 Gene

Orthologs for ZNF629 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF629 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF629 35 34
  • 99.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF629 35 34
  • 90.28 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF629 35 34
  • 90.25 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp629 17 35 34
  • 86.08 (n)
rat
(Rattus norvegicus)
Mammalia Zfp629 34
  • 85.99 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF629 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF629 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
-- 35
  • 40 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
-- 35
  • 34 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
-- 35
  • 27 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:zfos-44a5.2 35
  • 45 (a)
ManyToMany
BX640537.2 35
  • 41 (a)
ManyToMany
AL954741.1 35
  • 40 (a)
ManyToMany
CABZ01006831.1 35
  • 39 (a)
ManyToMany
CU672268.1 35
  • 38 (a)
ManyToMany
CABZ01006835.1 35
  • 38 (a)
ManyToMany
zgc:174712 35
  • 37 (a)
ManyToMany
CABZ01075191.1 35
  • 36 (a)
ManyToMany
si:dkey-20i20.5 35
  • 36 (a)
ManyToMany
si:ch211-235i11.2 35
  • 34 (a)
ManyToMany
CABZ01048402.1 35
  • 33 (a)
ManyToMany
BX000701.1 35
  • 32 (a)
ManyToMany
zgc:113389 35
  • 31 (a)
ManyToMany
FP326649.1 35
  • 30 (a)
ManyToMany
Species where no ortholog for ZNF629 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF629 Gene

ENSEMBL:
Gene Tree for ZNF629 (if available)
TreeFam:
Gene Tree for ZNF629 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF629: view image

Paralogs for ZNF629 Gene

Paralogs for ZNF629 Gene

(476) SIMAP similar genes for ZNF629 Gene using alignment to 1 proteins:

  • ZN629_HUMAN
genes like me logo Genes that share paralogs with ZNF629: view

Variants for ZNF629 Gene

Sequence variations from dbSNP and Humsavar for ZNF629 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000152871 -- 30,778,930(-) T/A 3_prime_UTR_variant
rs1000387459 -- 30,786,774(-) G/A intron_variant
rs1000611485 -- 30,783,891(-) G/A coding_sequence_variant, missense_variant
rs1001054900 -- 30,785,957(-) G/A/C intron_variant
rs1001081345 -- 30,782,609(-) C/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF629 Gene

Variant ID Type Subtype PubMed ID
nsv469724 CNV loss 16826518
nsv833188 CNV loss 17160897
nsv9438 CNV gain 18304495

Variation tolerance for ZNF629 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF629 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF629

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF629 Gene

Disorders for ZNF629 Gene

Additional Disease Information for ZNF629

No disorders were found for ZNF629 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF629 Gene

Publications for ZNF629 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 3 4 58
  3. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P … Dawid IB (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation. (PMID: 28695742) Saito  … Kobarg J (Journal of proteome research 2017) 3 58

Products for ZNF629 Gene

Sources for ZNF629 Gene

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