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Aliases for ZNF628 Gene

Aliases for ZNF628 Gene

  • Zinc Finger Protein 628 2 3 5
  • Zinc Finger Expressed In Embryonal Cells And Certain Adult Organs 2
  • Zinc Finger Protein Zec 3
  • Zfp628 3
  • ZEC 3

External Ids for ZNF628 Gene

Previous GeneCards Identifiers for ZNF628 Gene

  • GC19P060681
  • GC19P060492
  • GC19P055987
  • GC19P052302

Summaries for ZNF628 Gene

Entrez Gene Summary for ZNF628 Gene

  • Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (MIM 603971) for general information on ZNFs.[supplied by OMIM, Mar 2008]

GeneCards Summary for ZNF628 Gene

ZNF628 (Zinc Finger Protein 628) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for ZNF628 Gene

  • Transcription activator. Binds DNA on GT-box consensus sequence 5-TTGGTT-3 (By similarity).

Additional gene information for ZNF628 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF628 Gene

Genomics for ZNF628 Gene

GeneHancer (GH) Regulatory Elements for ZNF628 Gene

Promoters and enhancers for ZNF628 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055471 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 580.3 -1.2 -1174 6.4 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 ZNF628 ENSG00000269859 U2AF2 ENSG00000267523 ENSG00000267096 ZNF581 SSC5D NAT14 ZNF583 HSPBP1
GH19I055337 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 42.8 -136.5 -136504 4 CLOCK MLX FEZF1 DMAP1 YY1 E2F8 ZNF143 ZNF548 SP3 NFYC KMT5C ENSG00000276831 LENG8-AS1 U2AF2 LENG8 ZNF628 ENSG00000235681 ENSG00000267523 ENSG00000267096 FAM71E2
GH19I055459 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 42.5 -15.2 -15192 3.1 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ISOC2 U2AF2 ZNF628 ENSG00000267523 ZNF581 ZNF582 ENSG00000267096 SSC5D IL11 FIZ1
GH19I055405 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 39.3 -68.9 -68906 3.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 UBE2S U2AF2 ZNF628 LENG8 ENSG00000267523 ZNF581 LENG8-AS1 RPL28 ENSG00000235681 ENSG00000267096
GH19I055382 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.2 -89.5 -89468 8.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 RPL28 MIR6805 TMEM238 PIR44435 ZNF628 LENG8-AS1 ZNF581 U2AF2 COX6B2 BRSK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF628 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF628 gene promoter:

Genomic Locations for ZNF628 Gene

Genomic Locations for ZNF628 Gene
chr19:55,476,332-55,484,487
(GRCh38/hg38)
Size:
8,156 bases
Orientation:
Plus strand
chr19:55,987,699-55,995,854
(GRCh37/hg19)

Genomic View for ZNF628 Gene

Genes around ZNF628 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF628 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF628 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF628 Gene

Proteins for ZNF628 Gene

  • Protein details for ZNF628 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EBL2-ZN628_HUMAN
    Recommended name:
    Zinc finger protein 628
    Protein Accession:
    Q5EBL2
    Secondary Accessions:
    • Q86X34

    Protein attributes for ZNF628 Gene

    Size:
    1059 amino acids
    Molecular mass:
    110887 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH89449.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF628 Gene

Post-translational modifications for ZNF628 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF628 Gene

No data available for DME Specific Peptides for ZNF628 Gene

Domains & Families for ZNF628 Gene

Gene Families for ZNF628 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF628 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF628 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF628: view

No data available for UniProtKB/Swiss-Prot for ZNF628 Gene

Function for ZNF628 Gene

Molecular function for ZNF628 Gene

UniProtKB/Swiss-Prot Function:
Transcription activator. Binds DNA on GT-box consensus sequence 5-TTGGTT-3 (By similarity).

Phenotypes From GWAS Catalog for ZNF628 Gene

Gene Ontology (GO) - Molecular Function for ZNF628 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF628: view
genes like me logo Genes that share phenotypes with ZNF628: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF628 Gene

Localization for ZNF628 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF628 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF628 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF628 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF628: view

Pathways & Interactions for ZNF628 Gene

SuperPathways for ZNF628 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF628 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF628: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF628 Gene

Drugs & Compounds for ZNF628 Gene

No Compound Related Data Available

Transcripts for ZNF628 Gene

mRNA/cDNA for ZNF628 Gene

Unigene Clusters for ZNF628 Gene

Zinc finger protein 628:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF628 Gene

No ASD Table

Relevant External Links for ZNF628 Gene

GeneLoc Exon Structure for
ZNF628
ECgene alternative splicing isoforms for
ZNF628

Expression for ZNF628 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF628 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF628 Gene

This gene is overexpressed in Testis (x5.4).

Protein differential expression in normal tissues from HIPED for ZNF628 Gene

This gene is overexpressed in Spinal cord (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF628 Gene



Protein tissue co-expression partners for ZNF628 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF628 Gene:

ZNF628

SOURCE GeneReport for Unigene cluster for ZNF628 Gene:

Hs.525209

Evidence on tissue expression from TISSUES for ZNF628 Gene

  • Liver(4)
genes like me logo Genes that share expression patterns with ZNF628: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF628 Gene

Orthologs for ZNF628 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF628 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF628 33 34
  • 89.58 (n)
cow
(Bos Taurus)
Mammalia ZNF628 33 34
  • 85.6 (n)
dog
(Canis familiaris)
Mammalia ZNF628 33 34
  • 85.52 (n)
mouse
(Mus musculus)
Mammalia Zfp628 33 16 34
  • 81.38 (n)
rat
(Rattus norvegicus)
Mammalia Zfp628 33
  • 80.1 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF628 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF628 33 34
  • 65.1 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF628 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf628 33
  • 53.27 (n)
zebrafish
(Danio rerio)
Actinopterygii ZNF628 34
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7153 34
  • 24 (a)
OneToMany
Species where no ortholog for ZNF628 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF628 Gene

ENSEMBL:
Gene Tree for ZNF628 (if available)
TreeFam:
Gene Tree for ZNF628 (if available)

Paralogs for ZNF628 Gene

(248) SIMAP similar genes for ZNF628 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF628 Gene

genes like me logo Genes that share paralogs with ZNF628: view

No data available for Paralogs for ZNF628 Gene

Variants for ZNF628 Gene

Sequence variations from dbSNP and Humsavar for ZNF628 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000040544 -- 55,482,939(+) G/A coding_sequence_variant, synonymous_variant
rs1000057773 -- 55,483,437(+) C/T coding_sequence_variant, synonymous_variant
rs1000306157 -- 55,484,954(+) C/G downstream_transcript_variant
rs1000432426 -- 55,480,162(+) G/T intron_variant
rs1000934044 -- 55,477,017(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF628 Gene

Variant ID Type Subtype PubMed ID
nsv2552 CNV insertion 18451855
nsv458833 CNV loss 19166990
nsv580343 CNV loss 21841781
nsv953624 CNV deletion 24416366

Variation tolerance for ZNF628 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF628 Gene

Human Gene Mutation Database (HGMD)
ZNF628
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF628

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF628 Gene

Disorders for ZNF628 Gene

Additional Disease Information for ZNF628

No disorders were found for ZNF628 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF628 Gene

Publications for ZNF628 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S … Dorf ME (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 58
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  5. ZEC, a zinc finger protein with novel binding specificity and transcription regulatory activity. (PMID: 15556296) Chen GY … Muramatsu T (Gene 2004) 3 58

Products for ZNF628 Gene

Sources for ZNF628 Gene

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