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ZNF627 (Zinc Finger Protein 627) is a Protein Coding gene. Diseases associated with ZNF627 include Spondyloenchondrodysplasia With Immune Dysregulation and Spondyloenchondrodysplasia. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF136.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
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2 | Herpes simplex virus 1 infection |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: | - |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNF627 30 31 |
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OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zfp867 30 |
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Mouse (Mus musculus) |
Mammalia | Zfp867 30 17 |
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Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
638974 | Uncertain Significance: Spondyloenchondrodysplasia with immune dysregulation | 11,576,391(+) | C/T | MISSENSE_VARIANT | |
640476 | Uncertain Significance: Spondyloenchondrodysplasia with immune dysregulation | 11,577,155(+) | C/T | MISSENSE_VARIANT | |
647661 | Uncertain Significance: Spondyloenchondrodysplasia with immune dysregulation | 11,576,580(+) | G/C | MISSENSE_VARIANT | |
648426 | Uncertain Significance: Spondyloenchondrodysplasia with immune dysregulation | 11,577,169(+) | T/C | MISSENSE_VARIANT | |
651241 | Uncertain Significance: Spondyloenchondrodysplasia with immune dysregulation | 11,576,789(+) | C/T | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
spondyloenchondrodysplasia with immune dysregulation |
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spondyloenchondrodysplasia |
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