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Aliases for ZNF627 Gene

Aliases for ZNF627 Gene

  • Zinc Finger Protein 627 2 3 5

External Ids for ZNF627 Gene

Previous GeneCards Identifiers for ZNF627 Gene

  • GC19P011559
  • GC19P011709
  • GC19P011282
  • GC19P011674

Summaries for ZNF627 Gene

GeneCards Summary for ZNF627 Gene

ZNF627 (Zinc Finger Protein 627) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF564.

UniProtKB/Swiss-Prot for ZNF627 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF627 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF627 Gene

Genomics for ZNF627 Gene

GeneHancer (GH) Regulatory Elements for ZNF627 Gene

Promoters and enhancers for ZNF627 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I011557 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 550.8 +0.2 187 3.2 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 ELOF1 ZNF627 PRKCSH ZNF700 ZNF136 ZNF799 ZNF564 KRI1 ZNF20 ZNF44
GH19I011596 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 595.3 +38.1 38127 2.5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF627 ZNF136 ZNF20 ZNF564 ZNF700 ZNF44 ILF3 ZNF799 ZNF763 PRKCSH
GH19I011531 Enhancer 1.4 FANTOM5 Ensembl ENCODE 154.6 -26.9 -26936 1.6 PKNOX1 ATF1 ZNF493 ZFP64 ZNF213 FOS ZNF202 ZC3H11A REST ZNF623 ZNF627 ILF3 ZNF136 ZNF442 ZNF844 ZNF625 KRI1 ZNF44 ZNF441 ZNF709
GH19I010700 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 63 -857.7 -857699 1.7 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 E2F8 ZNF207 QTRT1 ZNF627 ILF3 LOC100419831 FBXL12 KRI1 DNMT1 RAVER1 YIPF2 CDC37
GH19I011343 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 62.9 -213.6 -213628 5 CLOCK FEZF1 DMAP1 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC MEF2D CCDC159 PIR44072 RAB3D PIR37751 TMEM205 ILF3 ZNF136 KRI1 ZNF627 ZNF844
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF627 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF627 gene promoter:

Genomic Locations for ZNF627 Gene

Genomic Locations for ZNF627 Gene
chr19:11,559,374-11,619,159
(GRCh38/hg38)
Size:
59,786 bases
Orientation:
Plus strand
chr19:11,670,189-11,729,974
(GRCh37/hg19)

Genomic View for ZNF627 Gene

Genes around ZNF627 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF627 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF627 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF627 Gene

Proteins for ZNF627 Gene

  • Protein details for ZNF627 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L945-ZN627_HUMAN
    Recommended name:
    Zinc finger protein 627
    Protein Accession:
    Q7L945
    Secondary Accessions:
    • O14846
    • Q4KMP9
    • Q6NT81
    • Q9BRG4

    Protein attributes for ZNF627 Gene

    Size:
    461 amino acids
    Molecular mass:
    52853 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH06279.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98416.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF627 Gene

Post-translational modifications for ZNF627 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF627 Gene

No data available for DME Specific Peptides for ZNF627 Gene

Domains & Families for ZNF627 Gene

Gene Families for ZNF627 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF627 Gene

Suggested Antigen Peptide Sequences for ZNF627 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L945

UniProtKB/Swiss-Prot:

ZN627_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF627: view

Function for ZNF627 Gene

Molecular function for ZNF627 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF627 Gene

Gene Ontology (GO) - Molecular Function for ZNF627 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF627: view

Phenotypes for ZNF627 Gene

GenomeRNAi human phenotypes for ZNF627:
genes like me logo Genes that share phenotypes with ZNF627: view

miRNA for ZNF627 Gene

miRTarBase miRNAs that target ZNF627

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF627 Gene

Localization for ZNF627 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF627 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF627 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF627 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF627: view

Pathways & Interactions for ZNF627 Gene

SuperPathways for ZNF627 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF627: view

Pathways by source for ZNF627 Gene

2 Reactome pathways for ZNF627 Gene

Gene Ontology (GO) - Biological Process for ZNF627 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF627: view

No data available for SIGNOR curated interactions for ZNF627 Gene

Drugs & Compounds for ZNF627 Gene

No Compound Related Data Available

Transcripts for ZNF627 Gene

Unigene Clusters for ZNF627 Gene

Zinc finger protein 627:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF627 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c
SP1:
SP2: -

Relevant External Links for ZNF627 Gene

GeneLoc Exon Structure for
ZNF627
ECgene alternative splicing isoforms for
ZNF627

Expression for ZNF627 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF627 Gene

Protein differential expression in normal tissues from HIPED for ZNF627 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF627 Gene



Protein tissue co-expression partners for ZNF627 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF627 Gene:

ZNF627

SOURCE GeneReport for Unigene cluster for ZNF627 Gene:

Hs.526665

Evidence on tissue expression from TISSUES for ZNF627 Gene

  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with ZNF627: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF627 Gene

Orthologs for ZNF627 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF627 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF627 33 34
  • 99.64 (n)
rat
(Rattus norvegicus)
Mammalia Zfp867 33
  • 69.9 (n)
mouse
(Mus musculus)
Mammalia Zfp867 33 16
  • 68.25 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 52 (a)
ManyToMany
Species where no ortholog for ZNF627 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF627 Gene

ENSEMBL:
Gene Tree for ZNF627 (if available)
TreeFam:
Gene Tree for ZNF627 (if available)

Paralogs for ZNF627 Gene

(470) SIMAP similar genes for ZNF627 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF627: view

Variants for ZNF627 Gene

Sequence variations from dbSNP and Humsavar for ZNF627 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs147025508 benign, likely-benign, not specified, not provided, Spondyloenchondrodysplasia with immune dysregulation 11,575,174(+) G/A/C upstream_transcript_variant
rs199580546 uncertain-significance, Spondyloenchondrodysplasia with immune dysregulation 11,576,719(+) C/T genic_upstream_transcript_variant, intron_variant
rs201184983 uncertain-significance, Spondyloenchondrodysplasia with immune dysregulation 11,577,181(+) C/T genic_upstream_transcript_variant, intron_variant
rs202233676 uncertain-significance, Spondyloenchondrodysplasia with immune dysregulation 11,577,073(+) T/A/C genic_upstream_transcript_variant, intron_variant
rs2229532 benign, Spondyloenchondrodysplasia with immune dysregulation 11,576,317(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF627 Gene

Variant ID Type Subtype PubMed ID
esv2464355 CNV insertion 19546169
esv2763196 CNV gain 21179565
nsv478794 CNV novel sequence insertion 20440878
nsv509721 CNV insertion 20534489
nsv513515 CNV insertion 21212237
nsv960785 CNV duplication 23825009

Variation tolerance for ZNF627 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF627 Gene

Human Gene Mutation Database (HGMD)
ZNF627
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF627

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF627 Gene

Disorders for ZNF627 Gene

Additional Disease Information for ZNF627

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF627 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF627 Gene

Publications for ZNF627 Gene

  1. Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population. (PMID: 18077766) Yamada Y … Nozawa Y (Journal of medical genetics 2008) 3 22 44 58
  2. Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. (PMID: 19709766) Koch W … Kastrati A (International journal of cardiology 2011) 3 44 58
  3. Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study. (PMID: 17967605) Horne BD … Intermountain Heart Collaborative Study Group (American heart journal 2007) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ZNF627 Gene

Sources for ZNF627 Gene

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