Aliases for ZNF627 Gene

Aliases for ZNF627 Gene

  • Zinc Finger Protein 627 2 3 4 5

External Ids for ZNF627 Gene

Previous GeneCards Identifiers for ZNF627 Gene

  • GC19P011559
  • GC19P011709
  • GC19P011282
  • GC19P011674

Summaries for ZNF627 Gene

GeneCards Summary for ZNF627 Gene

ZNF627 (Zinc Finger Protein 627) is a Protein Coding gene. Diseases associated with ZNF627 include Spondyloenchondrodysplasia With Immune Dysregulation and Spondyloenchondrodysplasia. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF136.

UniProtKB/Swiss-Prot Summary for ZNF627 Gene

Additional gene information for ZNF627 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF627 Gene

Genomics for ZNF627 Gene

GeneHancer (GH) Regulatory Elements for ZNF627 Gene

Promoters and enhancers for ZNF627 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011596 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 554.2 +38.6 38556 3.3 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 GTF2E2 PHF8 ZFX ZNF10 ZNF627 lnc-ACP5-3 ZNF136 ZNF564 ZNF700 ZNF44 ILF3 ZNF20 ZNF799 ZNF442
GH19J011557 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas 500.7 +0.1 127 3.4 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 USF1 POLR2G PHB2 ZNF10 ELOF1 ZNF627 lnc-CNN1-3 CCDC159 ACP5 LDLR lnc-ACP5-2
GH19J011531 Enhancer 1.1 FANTOM5 ENCODE 103.2 -26.9 -26936 1.6 RBAK JUND FOS ZNF639 ZNF354C ZNF623 ZNF510 ZEB1 ZNF266 FOSL1 ZNF136 ZNF627 ILF3 ZNF844 ZNF442 ZNF625 ZNF709 ZNF441 ZNF439 ZNF788P
GH19J011152 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 43.3 -404.8 -404810 4.9 FOXK2 ZNF217 SIN3A NRF1 POLR2G SP1 GTF2E2 FOS ZNF639 ZIC2 SPC24 lnc-LDLR-3 ILF3 KRI1 ZNF627 TIMM29 ZNF700 RAVER1 ZNF844 ZNF20
GH19J010834 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 39 -723.3 -723265 2.6 RXRA ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 MYC TCF12 POLR2G C19orf38 TMED1 ILF3 KRI1 ZNF627 DNMT1 ZNF491 ZNF441 RAVER1 PPAN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF627 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF627

Top Transcription factor binding sites by QIAGEN in the ZNF627 gene promoter:
  • CREB
  • deltaCREB
  • En-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GCNF
  • GCNF-1
  • GCNF-2
  • STAT5A

Genomic Locations for ZNF627 Gene

Genomic Locations for ZNF627 Gene
chr19:11,559,374-11,619,161
(GRCh38/hg38)
Size:
59,788 bases
Orientation:
Plus strand
chr19:11,670,189-11,729,974
(GRCh37/hg19)
Size:
59,786 bases
Orientation:
Plus strand

Genomic View for ZNF627 Gene

Genes around ZNF627 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF627 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF627 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF627 Gene

Proteins for ZNF627 Gene

  • Protein details for ZNF627 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L945-ZN627_HUMAN
    Recommended name:
    Zinc finger protein 627
    Protein Accession:
    Q7L945
    Secondary Accessions:
    • O14846
    • Q4KMP9
    • Q6NT81
    • Q9BRG4

    Protein attributes for ZNF627 Gene

    Size:
    461 amino acids
    Molecular mass:
    52853 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH06279.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98416.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF627 Gene

Post-translational modifications for ZNF627 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF627 Gene

No data available for DME Specific Peptides for ZNF627 Gene

Domains & Families for ZNF627 Gene

Gene Families for ZNF627 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF627 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF627 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 627 (ZN627_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7L945

UniProtKB/Swiss-Prot:

ZN627_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF627: view

Function for ZNF627 Gene

Molecular function for ZNF627 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF627 Gene

Gene Ontology (GO) - Molecular Function for ZNF627 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF627: view
genes like me logo Genes that share phenotypes with ZNF627: view

Animal Model Products

CRISPR Products

miRNA for ZNF627 Gene

miRTarBase miRNAs that target ZNF627

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF627 Gene

Localization for ZNF627 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF627 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF627 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF627 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF627: view

Pathways & Interactions for ZNF627 Gene

genes like me logo Genes that share pathways with ZNF627: view

Pathways by source for ZNF627 Gene

2 Reactome pathways for ZNF627 Gene
1 KEGG pathway for ZNF627 Gene

Gene Ontology (GO) - Biological Process for ZNF627 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF627: view

No data available for SIGNOR curated interactions for ZNF627 Gene

Drugs & Compounds for ZNF627 Gene

No Compound Related Data Available

Transcripts for ZNF627 Gene

mRNA/cDNA for ZNF627 Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF627 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c
SP1:
SP2: -

Relevant External Links for ZNF627 Gene

GeneLoc Exon Structure for
ZNF627

Expression for ZNF627 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF627 Gene

Protein differential expression in normal tissues from HIPED for ZNF627 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF627 Gene



Protein tissue co-expression partners for ZNF627 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF627

SOURCE GeneReport for Unigene cluster for ZNF627 Gene:

Hs.526665

Evidence on tissue expression from TISSUES for ZNF627 Gene

  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with ZNF627: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF627 Gene

Orthologs for ZNF627 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF627 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF627 31 30
  • 99.64 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp867 30
  • 69.9 (n)
mouse
(Mus musculus)
Mammalia Zfp867 17 30
  • 68.25 (n)
cow
(Bos Taurus)
Mammalia -- 31
  • 52 (a)
ManyToMany
Species where no ortholog for ZNF627 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF627 Gene

ENSEMBL:
Gene Tree for ZNF627 (if available)
TreeFam:
Gene Tree for ZNF627 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF627: view image

Paralogs for ZNF627 Gene

(470) SIMAP similar genes for ZNF627 Gene using alignment to 4 proteins:

  • ZN627_HUMAN
  • K7EJ27_HUMAN
  • K7EKY8_HUMAN
  • K7ELG4_HUMAN
genes like me logo Genes that share paralogs with ZNF627: view

Variants for ZNF627 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF627 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
638974 Uncertain Significance: Spondyloenchondrodysplasia with immune dysregulation 11,576,391(+) C/T MISSENSE_VARIANT
640476 Uncertain Significance: Spondyloenchondrodysplasia with immune dysregulation 11,577,155(+) C/T MISSENSE_VARIANT
647661 Uncertain Significance: Spondyloenchondrodysplasia with immune dysregulation 11,576,580(+) G/C MISSENSE_VARIANT
648426 Uncertain Significance: Spondyloenchondrodysplasia with immune dysregulation 11,577,169(+) T/C MISSENSE_VARIANT
651241 Uncertain Significance: Spondyloenchondrodysplasia with immune dysregulation 11,576,789(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF627 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF627 Gene

Variant ID Type Subtype PubMed ID
esv2464355 CNV insertion 19546169
esv2763196 CNV gain 21179565
nsv478794 CNV novel sequence insertion 20440878
nsv509721 CNV insertion 20534489
nsv513515 CNV insertion 21212237
nsv960785 CNV duplication 23825009

Variation tolerance for ZNF627 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF627 Gene

Human Gene Mutation Database (HGMD)
ZNF627
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF627

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF627 Gene

Disorders for ZNF627 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF627 Gene - From: GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF627

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF627: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF627 Gene

Publications for ZNF627 Gene

No publications were found for ZNF627 Gene.

Products for ZNF627 Gene

Sources for ZNF627 Gene