Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF626 Gene

Aliases for ZNF626 Gene

  • Zinc Finger Protein 626 2 3 5
  • CTC-513N18.7 3

External Ids for ZNF626 Gene

Previous GeneCards Identifiers for ZNF626 Gene

  • GC19M020802
  • GC19M020294
  • GC19M020772
  • GC19M021063

Summaries for ZNF626 Gene

GeneCards Summary for ZNF626 Gene

ZNF626 (Zinc Finger Protein 626) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF737.

UniProtKB/Swiss-Prot for ZNF626 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF626 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF626 Gene

Genomics for ZNF626 Gene

GeneHancer (GH) Regulatory Elements for ZNF626 Gene

Promoters and enhancers for ZNF626 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I020660 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 559.1 +0.4 399 2.1 HDAC1 ELF3 PKNOX1 FOXA2 TAF9B NFRKB ARID4B ZBTB40 DNMT3B ZNF48 ZNF626 ENSG00000269110 ENSG00000269779 RPL7AP10 ZNF431 GC19M022338 GC19M022340
GH19I020564 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 4.1 +96.1 96081 2.2 ELF3 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 RAD21 ELK1 FOS IKZF2 ZNF737 ZNF626 GC19M022326 GC19M022336 LOC105372316 ENSG00000269110
GH19I020663 Enhancer 0.8 Ensembl ENCODE 8.3 -3.4 -3389 2 DRAP1 ELF3 SOX5 SOX13 SAP130 MLX CEBPG ZGPAT CEBPA HOMEZ GC19M022338 ENSG00000269779 ZNF626
GH19I020610 Enhancer 0.4 ENCODE 8 +49.0 49033 3.4 PKNOX1 SCRT2 LOC105372318 ZNF626 ZNF56 ENSG00000268416 GC19P020618 ENSG00000269110
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF626 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF626 gene promoter:

Genomic Locations for ZNF626 Gene

Genomic Locations for ZNF626 Gene
chr19:20,619,939-20,661,596
(GRCh38/hg38)
Size:
41,658 bases
Orientation:
Minus strand
chr19:20,802,745-20,844,402
(GRCh37/hg19)

Genomic View for ZNF626 Gene

Genes around ZNF626 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF626 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF626 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF626 Gene

Proteins for ZNF626 Gene

  • Protein details for ZNF626 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DY1-ZN626_HUMAN
    Recommended name:
    Zinc finger protein 626
    Protein Accession:
    Q68DY1
    Secondary Accessions:
    • Q8N8T4
    • Q96QM1

    Protein attributes for ZNF626 Gene

    Size:
    528 amino acids
    Molecular mass:
    60893 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04729.1; Type=Miscellaneous discrepancy; Note=Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.; Evidence={ECO:0000305}; Sequence=CAH18089.1; Type=Miscellaneous discrepancy; Note=Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF626 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF626 Gene

Post-translational modifications for ZNF626 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF626 Gene

No data available for DME Specific Peptides for ZNF626 Gene

Domains & Families for ZNF626 Gene

Gene Families for ZNF626 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF626 Gene

Suggested Antigen Peptide Sequences for ZNF626 Gene

Graphical View of Domain Structure for InterPro Entry

Q68DY1

UniProtKB/Swiss-Prot:

ZN626_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF626: view

Function for ZNF626 Gene

Molecular function for ZNF626 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF626 Gene

Gene Ontology (GO) - Molecular Function for ZNF626 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF626: view
genes like me logo Genes that share phenotypes with ZNF626: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF626 Gene

Localization for ZNF626 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF626 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF626 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF626 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF626: view

Pathways & Interactions for ZNF626 Gene

SuperPathways for ZNF626 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF626: view

Pathways by source for ZNF626 Gene

2 Reactome pathways for ZNF626 Gene

Interacting Proteins for ZNF626 Gene

Gene Ontology (GO) - Biological Process for ZNF626 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF626: view

No data available for SIGNOR curated interactions for ZNF626 Gene

Drugs & Compounds for ZNF626 Gene

No Compound Related Data Available

Transcripts for ZNF626 Gene

mRNA/cDNA for ZNF626 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF626 Gene

Zinc finger protein 626:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF626 Gene

No ASD Table

Relevant External Links for ZNF626 Gene

GeneLoc Exon Structure for
ZNF626
ECgene alternative splicing isoforms for
ZNF626

Expression for ZNF626 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF626 Gene

Protein differential expression in normal tissues from HIPED for ZNF626 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF626 Gene



Protein tissue co-expression partners for ZNF626 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF626 Gene:

ZNF626

SOURCE GeneReport for Unigene cluster for ZNF626 Gene:

Hs.657001

Evidence on tissue expression from TISSUES for ZNF626 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF626: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF626 Gene

Orthologs for ZNF626 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF626 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 63 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 51 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 36 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp386 34
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 50 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
Species where no ortholog for ZNF626 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF626 Gene

ENSEMBL:
Gene Tree for ZNF626 (if available)
TreeFam:
Gene Tree for ZNF626 (if available)

Paralogs for ZNF626 Gene

(541) SIMAP similar genes for ZNF626 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF626 Gene

genes like me logo Genes that share paralogs with ZNF626: view

Variants for ZNF626 Gene

Sequence variations from dbSNP and Humsavar for ZNF626 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000030527 -- 20,651,553(-) G/A intron_variant
rs1000140112 -- 20,645,642(-) T/A intron_variant
rs1000221820 -- 20,657,752(-) C/A intron_variant
rs1000342226 -- 20,663,386(-) G/C upstream_transcript_variant
rs1000607368 -- 20,626,522(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF626 Gene

Variant ID Type Subtype PubMed ID
dgv1028e212 CNV gain 25503493
dgv3465n100 CNV loss 25217958
dgv3467n100 CNV gain 25217958
dgv3468n100 CNV gain 25217958
dgv404n27 CNV gain 19166990
dgv509e201 CNV deletion 23290073
dgv6304n54 CNV loss 21841781
dgv6318n54 CNV gain 21841781
dgv6319n54 CNV gain 21841781
dgv81e19 OTHER inversion 19470904
esv1003988 OTHER inversion 20482838
esv1010023 CNV deletion 20482838
esv1100051 CNV deletion 17803354
esv2573650 OTHER inversion 19546169
esv2718318 CNV deletion 23290073
esv2751781 CNV gain 17911159
esv2751782 CNV gain 17911159
esv2758749 CNV loss 17122850
esv2763043 CNV gain 21179565
esv3643886 CNV loss 21293372
esv3643892 CNV loss 21293372
esv3643893 CNV gain 21293372
esv3893177 CNV gain 25118596
nsv1072340 CNV deletion 25765185
nsv1141886 OTHER inversion 24896259
nsv436702 OTHER inversion 17901297
nsv458377 CNV gain 19166990
nsv458512 CNV gain 19166990
nsv510470 OTHER sequence alteration 20534489
nsv517256 CNV gain 19592680
nsv578809 CNV gain 21841781
nsv578910 CNV gain 21841781
nsv578913 CNV loss 21841781
nsv578914 CNV loss 21841781
nsv954632 CNV deletion 24416366
nsv9676 CNV gain 18304495
nsv978786 CNV duplication 23825009

Variation tolerance for ZNF626 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF626 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF626

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF626 Gene

Disorders for ZNF626 Gene

Additional Disease Information for ZNF626

No disorders were found for ZNF626 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF626 Gene

Publications for ZNF626 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila JL … Boerwinkle E (The pharmacogenomics journal 2014) 3 58
  4. A protein-protein interaction network of transcription factors acting during liver cell proliferation. (PMID: 18255255) Gao J … Yu Y (Genomics 2008) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ZNF626 Gene

Sources for ZNF626 Gene

Content
Loading form....