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Aliases for ZNF625 Gene

Aliases for ZNF625 Gene

  • Zinc Finger Protein 625 2 3 5

External Ids for ZNF625 Gene

Previous GeneCards Identifiers for ZNF625 Gene

  • GC19M012117
  • GC19M012104
  • GC19M012121
  • GC19M012122
  • GC19M012242
  • GC19M011830
  • GC19M012254
  • GC19M012255

Summaries for ZNF625 Gene

GeneCards Summary for ZNF625 Gene

ZNF625 (Zinc Finger Protein 625) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF433.

UniProtKB/Swiss-Prot for ZNF625 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF625 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF625 Gene

Genomics for ZNF625 Gene

GeneHancer (GH) Regulatory Elements for ZNF625 Gene

Promoters and enhancers for ZNF625 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I012155 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 572.7 +0.4 405 2.2 HDGF PKNOX1 FOXA2 ZNF133 ARID4B SIN3A GLI4 ZNF2 IRF4 ZNF48 ZNF625 ZNF625-ZNF20 ZNF627 ZNF20 ZNF136 TRMT1 RPL18AP13 ZNF44 ZNF442 ZNF844
GH19I012983 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 96.4 -828.1 -828071 3.2 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF136 ZNF625 ZNF442 ZNF844 CCDC130 ZNF564 ZNF799 WDR83OS ZNF788 ZNF709
GH19I011531 Enhancer 1.4 FANTOM5 Ensembl ENCODE 97.1 +624.3 624293 1.6 PKNOX1 ATF1 ZNF493 ZFP64 ZNF213 FOS ZNF202 ZC3H11A REST ZNF623 ZNF627 ILF3 ZNF136 ZNF442 ZNF844 ZNF625 KRI1 ZNF44 ZNF441 ZNF709
GH19I012936 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 49.2 -782.4 -782401 5.8 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 CALR MIR6515 ZNF136 CCDC130 TRMT1 ZNF625 RPS6P25 ZNF44 ZNF844 ZNF564
GH19I011343 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 43.6 +811.0 810985 5 CLOCK FEZF1 DMAP1 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC MEF2D CCDC159 PIR44072 RAB3D PIR37751 TMEM205 ILF3 ZNF136 KRI1 ZNF627 ZNF844
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF625 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF625 gene promoter:

Genomic Locations for ZNF625 Gene

Genomic Locations for ZNF625 Gene
chr19:12,142,090-12,156,731
(GRCh38/hg38)
Size:
14,642 bases
Orientation:
Minus strand
chr19:12,251,032-12,267,546
(GRCh37/hg19)

Genomic View for ZNF625 Gene

Genes around ZNF625 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF625 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF625 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF625 Gene

Proteins for ZNF625 Gene

  • Protein details for ZNF625 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96I27-ZN625_HUMAN
    Recommended name:
    Zinc finger protein 625
    Protein Accession:
    Q96I27
    Secondary Accessions:
    • A4FU45
    • I3L0E9

    Protein attributes for ZNF625 Gene

    Size:
    306 amino acids
    Molecular mass:
    34746 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF625 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF625 Gene

Post-translational modifications for ZNF625 Gene

No Post-translational modifications

Other Protein References for ZNF625 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF625 Gene

Domains & Families for ZNF625 Gene

Gene Families for ZNF625 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF625 Gene

Suggested Antigen Peptide Sequences for ZNF625 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96I27

UniProtKB/Swiss-Prot:

ZN625_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF625: view

Function for ZNF625 Gene

Molecular function for ZNF625 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF625 Gene

Gene Ontology (GO) - Molecular Function for ZNF625 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF625: view

Phenotypes for ZNF625 Gene

GenomeRNAi human phenotypes for ZNF625:
genes like me logo Genes that share phenotypes with ZNF625: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF625 Gene

Localization for ZNF625 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF625 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF625 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF625 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF625: view

Pathways & Interactions for ZNF625 Gene

SuperPathways for ZNF625 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF625: view

Pathways by source for ZNF625 Gene

2 Reactome pathways for ZNF625 Gene

Gene Ontology (GO) - Biological Process for ZNF625 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF625: view

No data available for SIGNOR curated interactions for ZNF625 Gene

Drugs & Compounds for ZNF625 Gene

No Compound Related Data Available

Transcripts for ZNF625 Gene

mRNA/cDNA for ZNF625 Gene

Unigene Clusters for ZNF625 Gene

Zinc finger protein 625:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF625 Gene

No ASD Table

Relevant External Links for ZNF625 Gene

GeneLoc Exon Structure for
ZNF625
ECgene alternative splicing isoforms for
ZNF625

Expression for ZNF625 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF625 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF625 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF625 Gene:

ZNF625

SOURCE GeneReport for Unigene cluster for ZNF625 Gene:

Hs.732736
genes like me logo Genes that share expression patterns with ZNF625: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF625 Gene

Orthologs for ZNF625 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF625 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF625 33 34
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 48 (a)
ManyToMany
Species where no ortholog for ZNF625 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF625 Gene

ENSEMBL:
Gene Tree for ZNF625 (if available)
TreeFam:
Gene Tree for ZNF625 (if available)

Paralogs for ZNF625 Gene

(531) SIMAP similar genes for ZNF625 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF625: view

Variants for ZNF625 Gene

Sequence variations from dbSNP and Humsavar for ZNF625 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000235145 -- 12,155,970(-) CCCCCC/CCCCCCC intron_variant
rs1000247500 -- 12,150,132(-) A/G intron_variant
rs1000319240 -- 12,149,762(-) G/A intron_variant
rs1000548840 -- 12,147,508(-) G/A intron_variant
rs1000700716 -- 12,154,454(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF625 Gene

Variant ID Type Subtype PubMed ID
nsv578619 CNV loss 21841781
nsv833753 CNV loss 17160897
nsv963006 CNV duplication 23825009

Variation tolerance for ZNF625 Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF625 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF625

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF625 Gene

Disorders for ZNF625 Gene

Additional Disease Information for ZNF625

No disorders were found for ZNF625 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF625 Gene

Publications for ZNF625 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart AE … Wells CM (The Journal of cell biology 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa RS … Obuse C (Nature cell biology 2010) 3 58

Products for ZNF625 Gene

Sources for ZNF625 Gene

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