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Aliases for ZNF624 Gene

Aliases for ZNF624 Gene

  • Zinc Finger Protein 624 2 3 5
  • KIAA1349 4

External Ids for ZNF624 Gene

Previous GeneCards Identifiers for ZNF624 Gene

  • GC17M016724
  • GC17M016464
  • GC17M016390
  • GC17M016524
  • GC17M016620

Summaries for ZNF624 Gene

GeneCards Summary for ZNF624 Gene

ZNF624 (Zinc Finger Protein 624) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF268.

UniProtKB/Swiss-Prot for ZNF624 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF624 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF624 Gene

Genomics for ZNF624 Gene

GeneHancer (GH) Regulatory Elements for ZNF624 Gene

Promoters and enhancers for ZNF624 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I016652 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 560.9 +2.1 2059 1.9 FOXA2 CLOCK ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF143 ZNF624 ENSG00000264765 ZNF286A UPF3AP1 NEK4P2 GC17P016634
GH17I017040 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.5 -388.2 -388238 6.1 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 MPRIP GC17P017043 GC17P017048 PIR46780 PIR43427 MPRIP-AS1 FLCN PIGL PLD6 NCOR1
GH17I017279 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.4 -625.3 -625283 2.6 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B E2F8 COPS3 PIR47486 PIR50772 FLCN NT5M DRG2 LOC644422 MPRIP-AS1 MPRIP FLII
GH17I016406 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +247.9 247915 2.2 HDGF SMAD1 ZFP64 SIN3A FEZF1 YBX1 IRF4 ZNF213 ZNF207 ZNF548 PIGL PPIAP53 ENSG00000266538 NCOR1 TVP23C MPRIP-AS1 ZNF286A LOC644422 UPF3AP1 MPRIP
GH17I016599 Enhancer 0.3 ENCODE 11.6 +55.9 55884 0.2 HNF4A ZNF624 LOC644422 GC17P016578
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF624 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF624 gene promoter:

Genomic Locations for ZNF624 Gene

Genomic Locations for ZNF624 Gene
chr17:16,599,870-16,655,626
(GRCh38/hg38)
Size:
55,757 bases
Orientation:
Minus strand
chr17:16,524,048-16,557,170
(GRCh37/hg19)

Genomic View for ZNF624 Gene

Genes around ZNF624 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF624 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF624 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF624 Gene

Proteins for ZNF624 Gene

  • Protein details for ZNF624 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2J8-ZN624_HUMAN
    Recommended name:
    Zinc finger protein 624
    Protein Accession:
    Q9P2J8
    Secondary Accessions:
    • Q3SY62
    • Q3SY63
    • Q6ZN27

    Protein attributes for ZNF624 Gene

    Size:
    865 amino acids
    Molecular mass:
    99929 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92587.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF624 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF624 Gene

Post-translational modifications for ZNF624 Gene

No Post-translational modifications

Other Protein References for ZNF624 Gene

No data available for DME Specific Peptides for ZNF624 Gene

Domains & Families for ZNF624 Gene

Gene Families for ZNF624 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF624 Gene

Suggested Antigen Peptide Sequences for ZNF624 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2J8

UniProtKB/Swiss-Prot:

ZN624_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF624: view

Function for ZNF624 Gene

Molecular function for ZNF624 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF624 Gene

Gene Ontology (GO) - Molecular Function for ZNF624 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF624: view
genes like me logo Genes that share phenotypes with ZNF624: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF624 Gene

Localization for ZNF624 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF624 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF624 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF624 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF624: view

Pathways & Interactions for ZNF624 Gene

SuperPathways for ZNF624 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF624: view

Pathways by source for ZNF624 Gene

2 Reactome pathways for ZNF624 Gene

Gene Ontology (GO) - Biological Process for ZNF624 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF624: view

No data available for SIGNOR curated interactions for ZNF624 Gene

Drugs & Compounds for ZNF624 Gene

No Compound Related Data Available

Transcripts for ZNF624 Gene

mRNA/cDNA for ZNF624 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF624 Gene

Zinc finger protein 624:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF624 Gene

No ASD Table

Relevant External Links for ZNF624 Gene

GeneLoc Exon Structure for
ZNF624
ECgene alternative splicing isoforms for
ZNF624

Expression for ZNF624 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF624 Gene

Protein differential expression in normal tissues from HIPED for ZNF624 Gene

This gene is overexpressed in Breast (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF624 Gene



Protein tissue co-expression partners for ZNF624 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF624 Gene:

ZNF624

SOURCE GeneReport for Unigene cluster for ZNF624 Gene:

Hs.128078

Evidence on tissue expression from TISSUES for ZNF624 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF624: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF624 Gene

Orthologs for ZNF624 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF624 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF624 33 34
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia ZNF624 33 34
  • 90.66 (n)
mouse
(Mus musculus)
Mammalia Gm3055 33 16
  • 61.99 (n)
Gm14124 34
  • 44 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100909569 33
  • 61.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 51 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
OneToMany
-- 34
  • 48 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF624 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858477 33
  • 54.11 (n)
Species where no ortholog for ZNF624 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF624 Gene

ENSEMBL:
Gene Tree for ZNF624 (if available)
TreeFam:
Gene Tree for ZNF624 (if available)

Paralogs for ZNF624 Gene

(528) SIMAP similar genes for ZNF624 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF624: view

Variants for ZNF624 Gene

Sequence variations from dbSNP and Humsavar for ZNF624 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
VAR_035592 A colorectal cancer sample p.Cys558Ser
rs1000002029 -- 16,657,005(-) G/A upstream_transcript_variant
rs1000055732 -- 16,642,781(-) T/C intron_variant
rs1000078097 -- 16,639,932(-) A/G intron_variant
rs1000232499 -- 16,635,719(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF624 Gene

Variant ID Type Subtype PubMed ID
nsv1063764 CNV loss 25217958
esv2758676 CNV gain+loss 17122850
esv2715702 CNV deletion 23290073

Variation tolerance for ZNF624 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.74; 89.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF624 Gene

Human Gene Mutation Database (HGMD)
ZNF624
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF624

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF624 Gene

Disorders for ZNF624 Gene

Additional Disease Information for ZNF624

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF624 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF624 Gene

Publications for ZNF624 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ZNF624 Gene

Sources for ZNF624 Gene

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