Aliases for ZNF623 Gene

Aliases for ZNF623 Gene

  • Zinc Finger Protein 623 2 3 4 5
  • KIAA0628 2 4
  • ZNF623 5

External Ids for ZNF623 Gene

Previous GeneCards Identifiers for ZNF623 Gene

  • GC08U900475
  • GC08P144804
  • GC08P144789
  • GC08P144718
  • GC08P139969

Summaries for ZNF623 Gene

GeneCards Summary for ZNF623 Gene

ZNF623 (Zinc Finger Protein 623) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF16.

UniProtKB/Swiss-Prot Summary for ZNF623 Gene

Additional gene information for ZNF623 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF623 Gene

Genomics for ZNF623 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF623 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF623 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF623

Top Transcription factor binding sites by QIAGEN in the ZNF623 gene promoter:
  • c-Ets-1
  • COMP1
  • CREB
  • NRF-2
  • POU2F1
  • POU2F1a
  • SEF-1 (1)
  • STAT1
  • STAT5A

Genomic Locations for ZNF623 Gene

Genomic Locations for ZNF623 Gene
chr8:143,636,013-143,656,418
(GRCh38/hg38)
Size:
20,406 bases
Orientation:
Plus strand
chr8:144,718,183-144,735,900
(GRCh37/hg19)
Size:
17,718 bases
Orientation:
Plus strand

Genomic View for ZNF623 Gene

Genes around ZNF623 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF623 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF623 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF623 Gene

Proteins for ZNF623 Gene

  • Protein details for ZNF623 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75123-ZN623_HUMAN
    Recommended name:
    Zinc finger protein 623
    Protein Accession:
    O75123
    Secondary Accessions:
    • A4FU80
    • B4DGP3
    • E7ENV5

    Protein attributes for ZNF623 Gene

    Size:
    536 amino acids
    Molecular mass:
    61393 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31603.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAG57854.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF623 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF623 Gene

Post-translational modifications for ZNF623 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF623 Gene

No data available for DME Specific Peptides for ZNF623 Gene

Domains & Families for ZNF623 Gene

Gene Families for ZNF623 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF623 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF623 Gene

GenScript: Design optimal peptide antigens:
  • ZNF623 protein (A4FU80_HUMAN)
  • Zinc finger protein 623 (ZN623_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75123

UniProtKB/Swiss-Prot:

ZN623_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF623: view

Function for ZNF623 Gene

Molecular function for ZNF623 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF623 Gene

Gene Ontology (GO) - Molecular Function for ZNF623 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF623: view
genes like me logo Genes that share phenotypes with ZNF623: view

Animal Model Products

CRISPR Products

miRNA for ZNF623 Gene

miRTarBase miRNAs that target ZNF623

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF623

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF623 Gene

Localization for ZNF623 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF623 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF623 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF623 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF623: view

Pathways & Interactions for ZNF623 Gene

PathCards logo

SuperPathways for ZNF623 Gene

genes like me logo Genes that share pathways with ZNF623: view

Pathways by source for ZNF623 Gene

1 KEGG pathway for ZNF623 Gene

Gene Ontology (GO) - Biological Process for ZNF623 Gene

None

No data available for SIGNOR curated interactions for ZNF623 Gene

Drugs & Compounds for ZNF623 Gene

No Compound Related Data Available

Transcripts for ZNF623 Gene

mRNA/cDNA for ZNF623 Gene

3 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF623

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF623 Gene

No ASD Table

Relevant External Links for ZNF623 Gene

GeneLoc Exon Structure for
ZNF623

Expression for ZNF623 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF623 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF623 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF623

SOURCE GeneReport for Unigene cluster for ZNF623 Gene:

Hs.694018

Evidence on tissue expression from TISSUES for ZNF623 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZNF623: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF623 Gene

Orthologs for ZNF623 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF623 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF623 30 31
  • 99.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF623 30 31
  • 85.31 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp623 30 17 31
  • 80.82 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC102547932 30
  • 80.61 (n)
Cow
(Bos Taurus)
Mammalia ZNF623 30 31
  • 78.93 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 42 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 40 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii BX927130.1 31
  • 39 (a)
OneToMany
Species where no ortholog for ZNF623 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF623 Gene

ENSEMBL:
Gene Tree for ZNF623 (if available)
TreeFam:
Gene Tree for ZNF623 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF623: view image

Paralogs for ZNF623 Gene

Paralogs for ZNF623 Gene

(508) SIMAP similar genes for ZNF623 Gene using alignment to 1 proteins:

  • ZN623_HUMAN
genes like me logo Genes that share paralogs with ZNF623: view

Variants for ZNF623 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF623 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs4874084 - p.Asp126Asn

Additional dbSNP identifiers (rs#s) for ZNF623 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF623 Gene

Variant ID Type Subtype PubMed ID
dgv12419n54 CNV loss 21841781
dgv12429n54 CNV loss 21841781
dgv2118e212 CNV loss 25503493
dgv271n111 CNV deletion 26073780
dgv3930n106 CNV deletion 24896259
esv1406298 CNV deletion 17803354
esv2738024 CNV deletion 23290073
esv3269385 CNV deletion 24192839
esv3544392 CNV deletion 23714750
esv3573036 CNV loss 25503493
esv3584899 CNV loss 24956385
esv4725 CNV loss 18987735
esv5538 CNV loss 19470904
nsv1077073 CNV deletion 25765185
nsv1150215 CNV deletion 26484159
nsv1161814 CNV deletion 26073780
nsv466004 CNV loss 19166990
nsv6439 CNV deletion 18451855
nsv6440 CNV insertion 18451855
nsv831488 CNV loss 17160897
nsv957688 CNV deletion 24416366

Variation tolerance for ZNF623 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF623 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF623

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF623 Gene

Disorders for ZNF623 Gene

No disorders were found for ZNF623 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF623 Gene

Publications for ZNF623 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4

Products for ZNF623 Gene

Sources for ZNF623 Gene