Aliases for ZNF623 Gene

Aliases for ZNF623 Gene

  • Zinc Finger Protein 623 2 3 4 5
  • KIAA0628 4

External Ids for ZNF623 Gene

Previous GeneCards Identifiers for ZNF623 Gene

  • GC08U900475
  • GC08P144804
  • GC08P144789
  • GC08P144718
  • GC08P139969

Summaries for ZNF623 Gene

GeneCards Summary for ZNF623 Gene

ZNF623 (Zinc Finger Protein 623) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF16.

UniProtKB/Swiss-Prot Summary for ZNF623 Gene

Additional gene information for ZNF623 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF623 Gene

Genomics for ZNF623 Gene

GeneHancer (GH) Regulatory Elements for ZNF623 Gene

Promoters and enhancers for ZNF623 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J143634 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 788.8 0.0 -12 3.2 ZBTB40 SMARCE1 RBPJ POLR2A HCFC1 CC2D1A ETV6 ELF1 ZNF121 MNT ZNF623 LOC105375798 VPS28 CPSF1 LRRC14 NAPRT ZNF707 JRK EEF1D ADCK5
GH08J144101 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 114.3 +468.1 468054 4.3 ZNF785 SIN3A ZNF24 SP1 ZBTB40 SREBF1 SIX5 RBPJ SMARCE1 POLR2A SHARPIN MAF1 ZNF7 ZNF623 VPS28 ZNF251 ZNF250 CPSF1 LRRC14 ZNF517
GH08J143595 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 100.8 -38.1 -38081 5.1 PPP1R10 ZNF785 SIN3A ZBTB40 SP1 SREBF1 SIX5 LCORL MLX RBPJ EEF1D TIGD5 ZC3H3 lnc-NAPRT-3 piR-51576 CPSF1 ZNF623 VPS28 NAPRT LRRC14
GH08J144455 Enhancer 1 ENCODE 180.4 +820.4 820433 1.6 E2F8 ZNF785 ZBTB40 SMARCE1 CTBP1 USF2 ATF1 CREB1 ZNF133 ZNF701 lnc-TONSL-3 ZNF623 ZNF7 ZNF251 ZNF16 LRRC14 VPS28 CPSF1 ZNF250 ZNF517
GH08J142725 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 71 -908.6 -908612 3.6 ZNF785 ZNF24 ZBTB40 SP1 CTCF SREBF1 RBPJ SMARCE1 POLR2A CC2D1A THEM6 ENSG00000253806 LNCOC1 ZNF623 JRK LY6K ZNF696 ZNF707 TSNARE1 GLI4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF623 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF623 gene promoter:
  • c-Ets-1
  • COMP1
  • CREB
  • NRF-2
  • POU2F1
  • POU2F1a
  • SEF-1 (1)
  • STAT1
  • STAT5A

Genomic Locations for ZNF623 Gene

Genomic Locations for ZNF623 Gene
20,406 bases
Plus strand
17,718 bases
Plus strand

Genomic View for ZNF623 Gene

Genes around ZNF623 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF623 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF623 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF623 Gene

Proteins for ZNF623 Gene

  • Protein details for ZNF623 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 623
    Protein Accession:
    Secondary Accessions:
    • A4FU80
    • B4DGP3
    • E7ENV5

    Protein attributes for ZNF623 Gene

    536 amino acids
    Molecular mass:
    61392 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA31603.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG57854.1; Type=Frameshift; Positions=467; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF623 Gene


neXtProt entry for ZNF623 Gene

Post-translational modifications for ZNF623 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF623 Gene

No data available for DME Specific Peptides for ZNF623 Gene

Domains & Families for ZNF623 Gene

Gene Families for ZNF623 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF623 Gene

Suggested Antigen Peptide Sequences for ZNF623 Gene

GenScript: Design optimal peptide antigens:
  • ZNF623 protein (A4FU80_HUMAN)
  • Zinc finger protein 623 (ZN623_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF623: view

Function for ZNF623 Gene

Molecular function for ZNF623 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF623 Gene

Gene Ontology (GO) - Molecular Function for ZNF623 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF623: view
genes like me logo Genes that share phenotypes with ZNF623: view

Animal Model Products

CRISPR Products

miRNA for ZNF623 Gene

miRTarBase miRNAs that target ZNF623

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF623 Gene

Localization for ZNF623 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF623 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF623 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF623 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF623: view

Pathways & Interactions for ZNF623 Gene

PathCards logo

SuperPathways for ZNF623 Gene

genes like me logo Genes that share pathways with ZNF623: view

Pathways by source for ZNF623 Gene

1 KEGG pathway for ZNF623 Gene

Gene Ontology (GO) - Biological Process for ZNF623 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF623: view

No data available for SIGNOR curated interactions for ZNF623 Gene

Drugs & Compounds for ZNF623 Gene

No Compound Related Data Available

Transcripts for ZNF623 Gene

mRNA/cDNA for ZNF623 Gene

(3) REFSEQ mRNAs :
(19) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF623 Gene

No ASD Table

Relevant External Links for ZNF623 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF623 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF623 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF623 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF623 Gene:


SOURCE GeneReport for Unigene cluster for ZNF623 Gene:


Evidence on tissue expression from TISSUES for ZNF623 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZNF623: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF623 Gene

Orthologs for ZNF623 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF623 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF623 33 32
  • 99.44 (n)
(Canis familiaris)
Mammalia ZNF623 33 32
  • 85.31 (n)
(Mus musculus)
Mammalia Zfp623 17 33 32
  • 80.82 (n)
(Rattus norvegicus)
Mammalia LOC102547932 32
  • 80.61 (n)
(Bos Taurus)
Mammalia ZNF623 33 32
  • 78.93 (n)
(Monodelphis domestica)
Mammalia -- 33
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 33
  • 40 (a)
(Danio rerio)
Actinopterygii BX927130.1 33
  • 39 (a)
Species where no ortholog for ZNF623 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF623 Gene

Gene Tree for ZNF623 (if available)
Gene Tree for ZNF623 (if available)
Evolutionary constrained regions (ECRs) for ZNF623: view image

Paralogs for ZNF623 Gene

Paralogs for ZNF623 Gene

(508) SIMAP similar genes for ZNF623 Gene using alignment to 1 proteins:

  • ZN623_HUMAN
genes like me logo Genes that share paralogs with ZNF623: view

Variants for ZNF623 Gene

Sequence variations from dbSNP and Humsavar for ZNF623 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000014832 -- 143,642,877(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000054712 -- 143,637,465(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000097853 -- 143,647,366(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000107844 -- 143,650,807(+) T/G coding_sequence_variant, missense_variant
rs1000387442 -- 143,642,666(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF623 Gene

Variant ID Type Subtype PubMed ID
dgv12419n54 CNV loss 21841781
dgv12429n54 CNV loss 21841781
dgv2118e212 CNV loss 25503493
dgv271n111 CNV deletion 26073780
dgv3930n106 CNV deletion 24896259
esv1406298 CNV deletion 17803354
esv2738024 CNV deletion 23290073
esv3269385 CNV deletion 24192839
esv3544392 CNV deletion 23714750
esv3573036 CNV loss 25503493
esv3584899 CNV loss 24956385
esv4725 CNV loss 18987735
esv5538 CNV loss 19470904
nsv1077073 CNV deletion 25765185
nsv1150215 CNV deletion 26484159
nsv1161814 CNV deletion 26073780
nsv466004 CNV loss 19166990
nsv6439 CNV deletion 18451855
nsv6440 CNV insertion 18451855
nsv831488 CNV loss 17160897
nsv957688 CNV deletion 24416366

Variation tolerance for ZNF623 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF623 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF623 Gene

Disorders for ZNF623 Gene

Additional Disease Information for ZNF623

No disorders were found for ZNF623 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF623 Gene

Publications for ZNF623 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 56
  5. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho CE … Valentini SR (Experimental cell research 2015) 3 56

Products for ZNF623 Gene

Sources for ZNF623 Gene