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Aliases for ZNF622 Gene

Aliases for ZNF622 Gene

  • Zinc Finger Protein 622 2 3 5
  • Zinc Finger-Like Protein 9 3 4
  • ZPR9 3 4

External Ids for ZNF622 Gene

Previous GeneCards Identifiers for ZNF622 Gene

  • GC05M016505
  • GC05M016506
  • GC05M016507

Summaries for ZNF622 Gene

GeneCards Summary for ZNF622 Gene

ZNF622 (Zinc Finger Protein 622) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF622 Gene

  • May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.

Additional gene information for ZNF622 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF622 Gene

Genomics for ZNF622 Gene

GeneHancer (GH) Regulatory Elements for ZNF622 Gene

Promoters and enhancers for ZNF622 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I016460 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.4 +5.9 5858 7.8 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B GC05P016465 ZNF622 LINC02150 FBXL7 GC05P016453
GH05I016468 Enhancer 0.3 dbSUPER 550.8 +0.9 918 1.1 ZNF362 ZNF622 ENSG00000250415 RETREG1 LINC02150 GC05P016465
GH05I016470 Enhancer 0.2 dbSUPER 550.8 -1.0 -952 1.1 ZNF622 LINC02150 ENSG00000250415 RETREG1 LOC101929524
GH05I016491 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 17.5 -22.6 -22632 2.6 RFX1 NFIB ZNF384 DPF2 E2F1 GATA3 JUND SCRT2 NFE2 FOS ZNF622 RETREG1 LOC101929524
GH05I016505 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 11.3 -38.0 -37950 4.6 FOXA2 KLF17 RAD21 RFX5 YY1 ZNF335 RCOR1 ELK4 SMARCC1 NFYA RETREG1 ZNF622 LOC101929524
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF622 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF622 gene promoter:

Genomic Locations for ZNF622 Gene

Genomic Locations for ZNF622 Gene
18,809 bases
Minus strand

Genomic View for ZNF622 Gene

Genes around ZNF622 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF622 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF622 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF622 Gene

Proteins for ZNF622 Gene

  • Protein details for ZNF622 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 622
    Protein Accession:

    Protein attributes for ZNF622 Gene

    477 amino acids
    Molecular mass:
    54272 Da
    Quaternary structure:
    • Homo- and heterodimer. Interacts with MELK and MYBL2 (PubMed:11802789, PubMed:12645566). Interacts with DNAJC21 (PubMed:27346687).

neXtProt entry for ZNF622 Gene

Post-translational modifications for ZNF622 Gene

  • Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus.
  • Ubiquitination at posLast=7575 and isoforms=116
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF622 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF622 Gene

Domains & Families for ZNF622 Gene

Gene Families for ZNF622 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF622 Gene

Suggested Antigen Peptide Sequences for ZNF622 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF622: view

No data available for UniProtKB/Swiss-Prot for ZNF622 Gene

Function for ZNF622 Gene

Molecular function for ZNF622 Gene

UniProtKB/Swiss-Prot Function:
May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.

Phenotypes From GWAS Catalog for ZNF622 Gene

Gene Ontology (GO) - Molecular Function for ZNF622 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22658674
GO:0005515 protein binding IPI 21771788
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF622: view
genes like me logo Genes that share phenotypes with ZNF622: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF622 Gene

Localization for ZNF622 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF622 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF622 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleus (4)
  • Nucleoli (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF622 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF622: view

Pathways & Interactions for ZNF622 Gene

SuperPathways for ZNF622 Gene

No Data Available

SIGNOR curated interactions for ZNF622 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ZNF622 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IDA 21771788
GO:0033674 positive regulation of kinase activity IDA 21771788
GO:0042273 ribosomal large subunit biogenesis IBA --
GO:0043065 positive regulation of apoptotic process IDA 21771788
GO:0043410 positive regulation of MAPK cascade IDA 21771788
genes like me logo Genes that share ontologies with ZNF622: view

No data available for Pathways by source for ZNF622 Gene

Drugs & Compounds for ZNF622 Gene

No Compound Related Data Available

Transcripts for ZNF622 Gene

mRNA/cDNA for ZNF622 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(192) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF622 Gene

Zinc finger protein 622:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF622 Gene

No ASD Table

Relevant External Links for ZNF622 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF622 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF622 Gene

Protein differential expression in normal tissues from HIPED for ZNF622 Gene

This gene is overexpressed in Lung (65.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF622 Gene

Protein tissue co-expression partners for ZNF622 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF622 Gene:


SOURCE GeneReport for Unigene cluster for ZNF622 Gene:


mRNA Expression by UniProt/SwissProt for ZNF622 Gene:

Tissue specificity: Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney.

Evidence on tissue expression from TISSUES for ZNF622 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZNF622: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF622 Gene

Orthologs for ZNF622 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZNF622 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF622 33 34
  • 97.55 (n)
(Rattus norvegicus)
Mammalia Zfp622 33
  • 86.38 (n)
(Bos Taurus)
Mammalia ZNF622 33 34
  • 85.53 (n)
(Mus musculus)
Mammalia Zfp622 33 16 34
  • 85.04 (n)
(Canis familiaris)
Mammalia ZNF622 33 34
  • 84.87 (n)
(Monodelphis domestica)
Mammalia ZNF622 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF622 34
  • 80 (a)
(Gallus gallus)
Aves ZNF622 33 34
  • 72.76 (n)
(Anolis carolinensis)
Reptilia ZNF622 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf622 33
  • 68.63 (n)
Str.10152 33
(Danio rerio)
Actinopterygii znf622 33 34
  • 67.04 (n)
wufb64b07 33
fruit fly
(Drosophila melanogaster)
Insecta CG6769 33 34
  • 55.62 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002118 33
  • 53.86 (n)
(Caenorhabditis elegans)
Secernentea C16A3.4 33 34
  • 48.21 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REI1 34
  • 31 (a)
REH1 34 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons FZF 33
  • 48.42 (n)
(Oryza sativa)
Liliopsida Os06g0693500 33
  • 50.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8710 34
  • 42 (a)
Species where no ortholog for ZNF622 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF622 Gene

Gene Tree for ZNF622 (if available)
Gene Tree for ZNF622 (if available)

Paralogs for ZNF622 Gene Pseudogenes for ZNF622 Gene

genes like me logo Genes that share paralogs with ZNF622: view

No data available for Paralogs for ZNF622 Gene

Variants for ZNF622 Gene

Sequence variations from dbSNP and Humsavar for ZNF622 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000081874 -- 16,456,032(-) G/A intron_variant
rs1000254191 -- 16,454,157(-) A/G intron_variant
rs1000909423 -- 16,461,826(-) G/C intron_variant
rs1000950932 -- 16,455,011(-) A/T intron_variant
rs1001085413 -- 16,454,765(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF622 Gene

Variant ID Type Subtype PubMed ID
esv3430353 CNV insertion 20981092

Variation tolerance for ZNF622 Gene

Residual Variation Intolerance Score: 14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF622 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF622 Gene

Disorders for ZNF622 Gene

Additional Disease Information for ZNF622

No disorders were found for ZNF622 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF622 Gene

Publications for ZNF622 Gene

  1. Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). (PMID: 11802789) Seong HA … Ha H (The Biochemical journal 2002) 2 3 4 22 58
  2. Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein. (PMID: 12645566) Seong HA … Ha H (The Journal of biological chemistry 2003) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. DNAJC21 Mutations Link a Cancer-Prone Bone Marrow Failure Syndrome to Corruption in 60S Ribosome Subunit Maturation. (PMID: 27346687) Tummala H … Vulliamy T (American journal of human genetics 2016) 4 58

Products for ZNF622 Gene

Sources for ZNF622 Gene

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