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Aliases for ZNF621 Gene

Aliases for ZNF621 Gene

  • Zinc Finger Protein 621 2 3 5

External Ids for ZNF621 Gene

Previous GeneCards Identifiers for ZNF621 Gene

  • GC03P040527
  • GC03P040541

Summaries for ZNF621 Gene

GeneCards Summary for ZNF621 Gene

ZNF621 (Zinc Finger Protein 621) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF619.

UniProtKB/Swiss-Prot for ZNF621 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF621 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF621 Gene

Genomics for ZNF621 Gene

GeneHancer (GH) Regulatory Elements for ZNF621 Gene

Promoters and enhancers for ZNF621 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I040523 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 639 2.2 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF621 ZNF619 ENTPD3-AS1 GC03M040586
GH03I041158 Enhancer 0.9 ENCODE 10 +635.3 635295 2.4 PKNOX1 ZNF493 ZFP64 FEZF1 ZNF2 ZNF213 KLF7 FOS ZNF202 ZC3H11A ZNF619 CTNNB1 ZNF620 ZNF621 ENSG00000233919 LOC105377045
GH03I041173 Enhancer 0.4 ENCODE 5.4 +651.3 651254 4.3 HLF ZIC2 ZNF621 ENSG00000233919 MRPS31P1
GH03I040503 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.4 -18.8 -18846 3.1 PKNOX1 FOXA2 ARID4B FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF143 FOS ZNF620 ZNF619 RPL14 ENTPD3-AS1 ZNF621
GH03I040584 Enhancer 1 Ensembl ENCODE 0.2 +60.7 60662 1.7 FOXA2 RB1 BATF RAD21 ZNF143 RCOR1 RUNX3 CREM SMARCA5 ZNF654 ENTPD3-AS1 CTNNB1 GC03M040586 ZNF621
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF621 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF621 gene promoter:

Genomic Locations for ZNF621 Gene

Genomic Locations for ZNF621 Gene
50,370 bases
Plus strand

Genomic View for ZNF621 Gene

Genes around ZNF621 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF621 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF621 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF621 Gene

Proteins for ZNF621 Gene

  • Protein details for ZNF621 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 621
    Protein Accession:
    Secondary Accessions:
    • Q14DC7
    • Q8TE91

    Protein attributes for ZNF621 Gene

    439 amino acids
    Molecular mass:
    49205 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF621 Gene


neXtProt entry for ZNF621 Gene

Post-translational modifications for ZNF621 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF621 Gene

Domains & Families for ZNF621 Gene

Gene Families for ZNF621 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF621 Gene

Suggested Antigen Peptide Sequences for ZNF621 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF621: view

Function for ZNF621 Gene

Molecular function for ZNF621 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF621: view
genes like me logo Genes that share phenotypes with ZNF621: view

Animal Model Products

miRNA for ZNF621 Gene

miRTarBase miRNAs that target ZNF621

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF621 Gene

Localization for ZNF621 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF621 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF621 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with ZNF621: view

Pathways & Interactions for ZNF621 Gene

SuperPathways for ZNF621 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF621: view

Pathways by source for ZNF621 Gene

2 Reactome pathways for ZNF621 Gene

Gene Ontology (GO) - Biological Process for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF621: view

No data available for SIGNOR curated interactions for ZNF621 Gene

Drugs & Compounds for ZNF621 Gene

No Compound Related Data Available

Transcripts for ZNF621 Gene

Unigene Clusters for ZNF621 Gene

Zinc finger protein 621:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF621 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for ZNF621 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF621 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF621 Gene

Protein differential expression in normal tissues from HIPED for ZNF621 Gene

This gene is overexpressed in Monocytes (34.3) and Blymphocyte (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF621 Gene

Protein tissue co-expression partners for ZNF621 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF621 Gene:


SOURCE GeneReport for Unigene cluster for ZNF621 Gene:


Evidence on tissue expression from TISSUES for ZNF621 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZNF621: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF621 Gene

Orthologs for ZNF621 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF621 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF621 33 34
  • 99.62 (n)
(Canis familiaris)
Mammalia ZNF621 34
  • 87 (a)
(Bos Taurus)
Mammalia LOC100849024 33
  • 84.6 (n)
Species where no ortholog for ZNF621 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF621 Gene

Gene Tree for ZNF621 (if available)
Gene Tree for ZNF621 (if available)

Paralogs for ZNF621 Gene

Paralogs for ZNF621 Gene

(498) SIMAP similar genes for ZNF621 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF621: view

Variants for ZNF621 Gene

Sequence variations from dbSNP and Humsavar for ZNF621 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000094609 -- 40,539,779(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000172178 -- 40,530,122(+) T/G intron_variant
rs1000205060 -- 40,529,863(+) T/G intron_variant
rs1000500391 -- 40,531,723(+) C/T intron_variant
rs1000530914 -- 40,531,487(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF621 Gene

Variant ID Type Subtype PubMed ID
esv2725188 CNV deletion 23290073
esv3595951 CNV loss 21293372

Variation tolerance for ZNF621 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF621 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF621 Gene

Disorders for ZNF621 Gene

Additional Disease Information for ZNF621

No disorders were found for ZNF621 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF621 Gene

Publications for ZNF621 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ZNF621 Gene

Sources for ZNF621 Gene

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