Aliases for ZNF621 Gene

Aliases for ZNF621 Gene

  • Zinc Finger Protein 621 2 3 4 5
  • FLJ45246 2
  • ZNF621 5

External Ids for ZNF621 Gene

Previous GeneCards Identifiers for ZNF621 Gene

  • GC03P040527
  • GC03P040541
  • GC03P040566

Summaries for ZNF621 Gene

GeneCards Summary for ZNF621 Gene

ZNF621 (Zinc Finger Protein 621) is a Protein Coding gene. Diseases associated with ZNF621 include Vasculopathy, Retinal, With Cerebral Leukodystrophy. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF182.

UniProtKB/Swiss-Prot Summary for ZNF621 Gene

Additional gene information for ZNF621 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF621 Gene

Genomics for ZNF621 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF621 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J040523 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.2 1247 2.6 ARHGAP35 SP1 CREB1 GATAD2A HNRNPL PRDM10 TFE3 RFX1 LEF1 ZNF692 ZNF621 lnc-ULK4-15 ZNF619 CTNNB1 ENTPD3-AS1 HSALNG0025333
GH03J040503 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 610.8 -18.2 -18185 3.5 HNRNPL GATAD2A CTCF TEAD4 PRDM10 ZNF629 TFE3 NFKBIZ KDM1A TARDBP ZNF620 ZNF621 ENTPD3-AS1 ZNF619 RPL14 lnc-ULK4-12
GH03J041158 Enhancer 1 Ensembl ENCODE 4.5 +635.5 635547 2.8 ZNF629 ZNF692 ZNF501 ZNF140 ZBTB20 ZNF639 KLF7 ZXDB ESR1 TSHZ1 ZNF619 CTNNB1 ZNF620 ENSG00000233919 ZNF621 piR-55985-127
GH03J041173 Enhancer 0.6 Ensembl ENCODE 5.4 +651.7 651716 4.3 ZIC2 TRIM28 HLF ESRRA lnc-CTNNB1-2 lnc-CTNNB1-3 ZNF621 ENSG00000233919 CTNNB1
GH03J040501 Enhancer 0.3 Ensembl 11.3 -22.8 -22753 0.2 ZNF384 lnc-ULK4-12 ZNF621 ZNF619 ENTPD3-AS1 RPL14 ENSG00000226302 ZNF620
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF621 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF621

Top Transcription factor binding sites by QIAGEN in the ZNF621 gene promoter:
  • AREB6
  • C/EBPbeta
  • Ik-1
  • Ik-2
  • Ik-3

Genomic Locations for ZNF621 Gene

Genomic Locations for ZNF621 Gene
chr3:40,523,854-40,574,685
(GRCh38/hg38)
Size:
50,832 bases
Orientation:
Plus strand
chr3:40,566,369-40,616,176
(GRCh37/hg19)
Size:
49,808 bases
Orientation:
Plus strand

Genomic View for ZNF621 Gene

Genes around ZNF621 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF621 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF621 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF621 Gene

Proteins for ZNF621 Gene

  • Protein details for ZNF621 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZSS3-ZN621_HUMAN
    Recommended name:
    Zinc finger protein 621
    Protein Accession:
    Q6ZSS3
    Secondary Accessions:
    • Q14DC7
    • Q8TE91

    Protein attributes for ZNF621 Gene

    Size:
    439 amino acids
    Molecular mass:
    49205 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF621 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF621 Gene

Post-translational modifications for ZNF621 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF621 Gene

Domains & Families for ZNF621 Gene

Gene Families for ZNF621 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF621 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF621 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 621 (ZN621_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZSS3

UniProtKB/Swiss-Prot:

ZN621_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF621: view

Function for ZNF621 Gene

Molecular function for ZNF621 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF621 Gene

Gene Ontology (GO) - Molecular Function for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF621: view
genes like me logo Genes that share phenotypes with ZNF621: view

Animal Model Products

CRISPR Products

miRNA for ZNF621 Gene

miRTarBase miRNAs that target ZNF621

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF621

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF621 Gene

Localization for ZNF621 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF621 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF621 gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF621: view

Pathways & Interactions for ZNF621 Gene

genes like me logo Genes that share pathways with ZNF621: view

Pathways by source for ZNF621 Gene

2 Reactome pathways for ZNF621 Gene
1 KEGG pathway for ZNF621 Gene

Gene Ontology (GO) - Biological Process for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF621: view

No data available for SIGNOR curated interactions for ZNF621 Gene

Drugs & Compounds for ZNF621 Gene

No Compound Related Data Available

Transcripts for ZNF621 Gene

mRNA/cDNA for ZNF621 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF621

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF621 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for ZNF621 Gene

GeneLoc Exon Structure for
ZNF621

Expression for ZNF621 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF621 Gene

Protein differential expression in normal tissues from HIPED for ZNF621 Gene

This gene is overexpressed in Monocytes (34.3) and Blymphocyte (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF621 Gene



Protein tissue co-expression partners for ZNF621 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF621

SOURCE GeneReport for Unigene cluster for ZNF621 Gene:

Hs.19977

Evidence on tissue expression from TISSUES for ZNF621 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZNF621: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF621 Gene

Orthologs for ZNF621 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF621 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF621 30 31
  • 99.62 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF621 31
  • 87 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC100849024 30
  • 84.6 (n)
Species where no ortholog for ZNF621 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF621 Gene

ENSEMBL:
Gene Tree for ZNF621 (if available)
TreeFam:
Gene Tree for ZNF621 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF621: view image

Paralogs for ZNF621 Gene

Paralogs for ZNF621 Gene

(498) SIMAP similar genes for ZNF621 Gene using alignment to 3 proteins:

  • ZN621_HUMAN
  • C9JM43_HUMAN
  • C9JZC2_HUMAN
genes like me logo Genes that share paralogs with ZNF621: view

Variants for ZNF621 Gene

Additional dbSNP identifiers (rs#s) for ZNF621 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF621 Gene

Variant ID Type Subtype PubMed ID
esv2725188 CNV deletion 23290073
esv3595951 CNV loss 21293372

Variation tolerance for ZNF621 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF621 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF621

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF621 Gene

Disorders for ZNF621 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF621 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vasculopathy, retinal, with cerebral leukodystrophy
  • rvcl
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF621: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF621 Gene

Publications for ZNF621 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4

Products for ZNF621 Gene

  • Signalway Proteins for ZNF621

Sources for ZNF621 Gene