Aliases for ZNF620 Gene

Aliases for ZNF620 Gene

  • Zinc Finger Protein 620 2 3 4 5
  • MGC50836 2
  • ZNF620 5

External Ids for ZNF620 Gene

Previous GeneCards Identifiers for ZNF620 Gene

  • GC03P040509
  • GC03P040522
  • GC03P040550

Summaries for ZNF620 Gene

GeneCards Summary for ZNF620 Gene

ZNF620 (Zinc Finger Protein 620) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF619.

UniProtKB/Swiss-Prot Summary for ZNF620 Gene

Additional gene information for ZNF620 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF620 Gene

Genomics for ZNF620 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF620 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J040503 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 615.4 +28.5 28538 3.5 HNRNPL GATAD2A CTCF TEAD4 PRDM10 ZNF629 TFE3 NFKBIZ KDM1A TARDBP ZNF620 ZNF621 ENTPD3-AS1 ZNF619 RPL14 lnc-ULK4-12
GH03J040476 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.1 70 2 IKZF1 ZNF692 JUND ZNF143 RBFOX2 PKNOX1 NR2C1 IKZF2 ZNF501 POLR2A ZNF619 ZNF620 lnc-ULK4-16 ENTPD3-AS1 RPL14 piR-37895-097 ZNF621
GH03J041198 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.9 +724.4 724370 6.6 RNF2 SP1 GATAD2A CTCF HNRNPL TEAD4 REST ZNF629 TFE3 IKZF1 CTNNB1 ZNF619 ZNF620 RPL14 ENSG00000234287 ULK4 TRAK1 lnc-ULK4-1
GH03J041158 Enhancer 1 Ensembl ENCODE 11.4 +682.3 682270 2.8 ZNF629 ZNF692 ZNF501 ZNF140 ZBTB20 ZNF639 KLF7 ZXDB ESR1 TSHZ1 ZNF619 CTNNB1 ZNF620 ENSG00000233919 ZNF621 piR-55985-127
GH03J040580 Enhancer 0.7 ENCODE 12 +103.6 103584 0.1 CTCF TEAD4 JUND ZNF143 REST RAD21 TRIM22 SOX6 ZNF316 SMC3 ZNF620 CTNNB1 lnc-ULK4-11 piR-41245-169 ZNF621
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF620 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF620

Top Transcription factor binding sites by QIAGEN in the ZNF620 gene promoter:
  • AREB6
  • C/EBPbeta
  • Ik-1
  • Ik-2
  • Ik-3

Genomic Locations for ZNF620 Gene

Genomic Locations for ZNF620 Gene
41,606 bases
Plus strand
12,745 bases
Plus strand

Genomic View for ZNF620 Gene

Genes around ZNF620 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF620 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF620 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF620 Gene

Proteins for ZNF620 Gene

  • Protein details for ZNF620 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 620
    Protein Accession:
    Secondary Accessions:
    • Q8N223

    Protein attributes for ZNF620 Gene

    422 amino acids
    Molecular mass:
    48503 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF620 Gene


neXtProt entry for ZNF620 Gene

Post-translational modifications for ZNF620 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF620 Gene

Domains & Families for ZNF620 Gene

Gene Families for ZNF620 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF620 Gene

  • C2H2-type zinc finger signature
  • KRAB box

Suggested Antigen Peptide Sequences for ZNF620 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 620 (ZN620_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF620: view

Function for ZNF620 Gene

Molecular function for ZNF620 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF620 Gene

Gene Ontology (GO) - Molecular Function for ZNF620 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF620: view
genes like me logo Genes that share phenotypes with ZNF620: view

Animal Model Products

CRISPR Products

miRNA for ZNF620 Gene

miRTarBase miRNAs that target ZNF620

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF620

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF620 Gene

Localization for ZNF620 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF620 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF620 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF620 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF620: view

Pathways & Interactions for ZNF620 Gene

genes like me logo Genes that share pathways with ZNF620: view

Pathways by source for ZNF620 Gene

2 Reactome pathways for ZNF620 Gene
1 KEGG pathway for ZNF620 Gene

Gene Ontology (GO) - Biological Process for ZNF620 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF620: view

No data available for SIGNOR curated interactions for ZNF620 Gene

Drugs & Compounds for ZNF620 Gene

No Compound Related Data Available

Transcripts for ZNF620 Gene

mRNA/cDNA for ZNF620 Gene

6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF620

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF620 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: -
SP3: - - - - -
SP4: - - - -

Relevant External Links for ZNF620 Gene

GeneLoc Exon Structure for

Expression for ZNF620 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF620 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF620

SOURCE GeneReport for Unigene cluster for ZNF620 Gene:


Evidence on tissue expression from TISSUES for ZNF620 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF620: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF620 Gene

Orthologs for ZNF620 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF620 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF620 30 31
  • 99.61 (n)
(Canis familiaris)
Mammalia ZNF621 30
  • 86.78 (n)
ZNF620 31
  • 71 (a)
Species where no ortholog for ZNF620 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF620 Gene

Gene Tree for ZNF620 (if available)
Gene Tree for ZNF620 (if available)
Evolutionary constrained regions (ECRs) for ZNF620: view image

Paralogs for ZNF620 Gene

(491) SIMAP similar genes for ZNF620 Gene using alignment to 3 proteins:

  • ZN620_HUMAN
  • C9J967_HUMAN
  • F8WC31_HUMAN Pseudogenes for ZNF620 Gene

genes like me logo Genes that share paralogs with ZNF620: view

Variants for ZNF620 Gene

Additional dbSNP identifiers (rs#s) for ZNF620 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF620 Gene

Variant ID Type Subtype PubMed ID
nsv818137 CNV loss 17921354

Variation tolerance for ZNF620 Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF620 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF620 Gene

Disorders for ZNF620 Gene

Additional Disease Information for ZNF620

No disorders were found for ZNF620 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF620 Gene

Publications for ZNF620 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF620 Gene

Sources for ZNF620 Gene