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Aliases for ZNF619 Gene

Aliases for ZNF619 Gene

  • Zinc Finger Protein 619 2 3 5

External Ids for ZNF619 Gene

Previous GeneCards Identifiers for ZNF619 Gene

  • GC03P040480
  • GC03P040493

Summaries for ZNF619 Gene

GeneCards Summary for ZNF619 Gene

ZNF619 (Zinc Finger Protein 619) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF621.

UniProtKB/Swiss-Prot for ZNF619 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF619 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF619 Gene

Genomics for ZNF619 Gene

GeneHancer (GH) Regulatory Elements for ZNF619 Gene

Promoters and enhancers for ZNF619 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I040476 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 561.4 +0.1 67 1.6 PKNOX1 SMAD1 ATF1 ARNT ARID4B SIN3A ZNF48 YY1 POLR2B ZNF766 ZNF619 ENTPD3-AS1 RPL14 RNU5B-2P GC03M040498
GH03I041158 Enhancer 0.9 ENCODE 69.9 +682.5 682498 2.4 PKNOX1 ZNF493 ZFP64 FEZF1 ZNF2 ZNF213 KLF7 FOS ZNF202 ZC3H11A ZNF619 CTNNB1 ZNF620 ZNF621 ENSG00000233919 LOC105377045
GH03I041198 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.6 +724.0 723999 5.2 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 CTNNB1 ZNF619 RPL14 ENSG00000234287 PIR45194
GH03I040456 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11 -19.3 -19312 3.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 RPL14 ENTPD3-AS1 ZNF619 ENTPD3 PIR56082
GH03I040308 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 -167.0 -166976 2.9 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 EIF1B EIF1B-AS1 SNORA62 ENTPD3-AS1 ZNF619 RPL14 PGAM1P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF619 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF619 gene promoter:

Genomic Locations for ZNF619 Gene

Genomic Locations for ZNF619 Gene
chr3:40,477,113-40,490,237
(GRCh38/hg38)
Size:
13,125 bases
Orientation:
Plus strand
chr3:40,518,604-40,531,728
(GRCh37/hg19)

Genomic View for ZNF619 Gene

Genes around ZNF619 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF619 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF619 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF619 Gene

Proteins for ZNF619 Gene

  • Protein details for ZNF619 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2I2-ZN619_HUMAN
    Recommended name:
    Zinc finger protein 619
    Protein Accession:
    Q8N2I2
    Secondary Accessions:
    • B4E271
    • C9JRN5
    • D4PHA2
    • E9PCD9

    Protein attributes for ZNF619 Gene

    Size:
    560 amino acids
    Molecular mass:
    63322 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF619 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF619 Gene

Post-translational modifications for ZNF619 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF619 Gene

Domains & Families for ZNF619 Gene

Gene Families for ZNF619 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF619 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N2I2

UniProtKB/Swiss-Prot:

ZN619_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF619: view

Function for ZNF619 Gene

Molecular function for ZNF619 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF619 Gene

Gene Ontology (GO) - Molecular Function for ZNF619 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF619: view
genes like me logo Genes that share phenotypes with ZNF619: view

miRNA for ZNF619 Gene

miRTarBase miRNAs that target ZNF619

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF619 Gene

Localization for ZNF619 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF619 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF619 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF619 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF619: view

Pathways & Interactions for ZNF619 Gene

SuperPathways for ZNF619 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF619: view

Pathways by source for ZNF619 Gene

2 Reactome pathways for ZNF619 Gene

Interacting Proteins for ZNF619 Gene

Gene Ontology (GO) - Biological Process for ZNF619 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF619: view

No data available for SIGNOR curated interactions for ZNF619 Gene

Drugs & Compounds for ZNF619 Gene

No Compound Related Data Available

Transcripts for ZNF619 Gene

Unigene Clusters for ZNF619 Gene

Zinc finger protein 619:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF619 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for ZNF619 Gene

GeneLoc Exon Structure for
ZNF619
ECgene alternative splicing isoforms for
ZNF619

Expression for ZNF619 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF619 Gene

Protein differential expression in normal tissues from HIPED for ZNF619 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF619 Gene



Protein tissue co-expression partners for ZNF619 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF619 Gene:

ZNF619

SOURCE GeneReport for Unigene cluster for ZNF619 Gene:

Hs.407159

Evidence on tissue expression from TISSUES for ZNF619 Gene

  • Thyroid gland(4.1)
genes like me logo Genes that share expression patterns with ZNF619: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF619 Gene

Orthologs for ZNF619 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF619 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF619 33 34
  • 99.19 (n)
cow
(Bos Taurus)
Mammalia ZNF619 33
  • 82.04 (n)
ZNF621 34
  • 38 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF619 33 34
  • 80.62 (n)
Species where no ortholog for ZNF619 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF619 Gene

ENSEMBL:
Gene Tree for ZNF619 (if available)
TreeFam:
Gene Tree for ZNF619 (if available)

Paralogs for ZNF619 Gene

Paralogs for ZNF619 Gene

(521) SIMAP similar genes for ZNF619 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF619 Gene

genes like me logo Genes that share paralogs with ZNF619: view

Variants for ZNF619 Gene

Sequence variations from dbSNP and Humsavar for ZNF619 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000310138 -- 40,484,648(+) C/G/T intron_variant
rs1000819198 -- 40,477,137(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000856028 -- 40,483,390(+) A/G intron_variant
rs1000991368 -- 40,483,746(+) A/C intron_variant
rs1000997174 -- 40,486,135(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF619 Gene

Variant ID Type Subtype PubMed ID
nsv818137 CNV loss 17921354

Variation tolerance for ZNF619 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.08; 68.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF619 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF619

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF619 Gene

Disorders for ZNF619 Gene

Additional Disease Information for ZNF619

No disorders were found for ZNF619 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF619 Gene

Publications for ZNF619 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L … Green MR (PLoS genetics 2012) 3 58
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for ZNF619 Gene

Sources for ZNF619 Gene

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