Aliases for ZNF619 Gene

Aliases for ZNF619 Gene

  • Zinc Finger Protein 619 2 3 4 5
  • FLJ90764 2
  • ZNF619 5

External Ids for ZNF619 Gene

Previous GeneCards Identifiers for ZNF619 Gene

  • GC03P040480
  • GC03P040493

Summaries for ZNF619 Gene

GeneCards Summary for ZNF619 Gene

ZNF619 (Zinc Finger Protein 619) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF620.

UniProtKB/Swiss-Prot Summary for ZNF619 Gene

Additional gene information for ZNF619 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF619 Gene

Genomics for ZNF619 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF619 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF619 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF619

Top Transcription factor binding sites by QIAGEN in the ZNF619 gene promoter:
  • AhR
  • Arnt
  • C/EBPbeta
  • E2F
  • E2F-1
  • HEN1
  • Nkx5-1
  • Pax-4a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ZNF619 Gene

Genomic Locations for ZNF619 Gene
chr3:40,477,113-40,491,053
(GRCh38/hg38)
Size:
13,941 bases
Orientation:
Plus strand
chr3:40,518,604-40,531,728
(GRCh37/hg19)
Size:
13,125 bases
Orientation:
Plus strand

Genomic View for ZNF619 Gene

Genes around ZNF619 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF619 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF619 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF619 Gene

Proteins for ZNF619 Gene

  • Protein details for ZNF619 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2I2-ZN619_HUMAN
    Recommended name:
    Zinc finger protein 619
    Protein Accession:
    Q8N2I2
    Secondary Accessions:
    • B4E271
    • C9JRN5
    • D4PHA2
    • E9PCD9

    Protein attributes for ZNF619 Gene

    Size:
    560 amino acids
    Molecular mass:
    63322 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF619 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF619 Gene

Post-translational modifications for ZNF619 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF619 Gene

Domains & Families for ZNF619 Gene

Gene Families for ZNF619 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF619 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF619 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56204, highly similar to Zinc finger protein 619 (B4E271_HUMAN)
  • cDNA FLJ51615, highly similar to Zinc finger protein 619 (B4E3N1_HUMAN)
  • ZNF619 protein (Q17RW3_HUMAN)
  • Zinc finger protein 619 (ZN619_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N2I2

UniProtKB/Swiss-Prot:

ZN619_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF619: view

Function for ZNF619 Gene

Molecular function for ZNF619 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF619 Gene

Gene Ontology (GO) - Molecular Function for ZNF619 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF619: view
genes like me logo Genes that share phenotypes with ZNF619: view

Animal Model Products

CRISPR Products

miRNA for ZNF619 Gene

miRTarBase miRNAs that target ZNF619

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF619

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF619 Gene

Localization for ZNF619 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF619 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF619 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF619 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF619: view

Pathways & Interactions for ZNF619 Gene

genes like me logo Genes that share pathways with ZNF619: view

Pathways by source for ZNF619 Gene

2 Reactome pathways for ZNF619 Gene
1 KEGG pathway for ZNF619 Gene

Interacting Proteins for ZNF619 Gene

Gene Ontology (GO) - Biological Process for ZNF619 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF619: view

No data available for SIGNOR curated interactions for ZNF619 Gene

Drugs & Compounds for ZNF619 Gene

No Compound Related Data Available

Transcripts for ZNF619 Gene

mRNA/cDNA for ZNF619 Gene

7 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF619

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF619 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for ZNF619 Gene

GeneLoc Exon Structure for
ZNF619

Expression for ZNF619 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF619 Gene

Protein differential expression in normal tissues from HIPED for ZNF619 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF619 Gene



Protein tissue co-expression partners for ZNF619 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF619

SOURCE GeneReport for Unigene cluster for ZNF619 Gene:

Hs.407159

Evidence on tissue expression from TISSUES for ZNF619 Gene

  • Thyroid gland(4.1)
genes like me logo Genes that share expression patterns with ZNF619: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF619 Gene

Orthologs for ZNF619 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF619 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF619 30 31
  • 99.19 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF619 30
  • 82.04 (n)
ZNF621 31
  • 38 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF619 30 31
  • 80.62 (n)
OneToOne
Species where no ortholog for ZNF619 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF619 Gene

ENSEMBL:
Gene Tree for ZNF619 (if available)
TreeFam:
Gene Tree for ZNF619 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF619: view image

Paralogs for ZNF619 Gene

(521) SIMAP similar genes for ZNF619 Gene using alignment to 5 proteins:

  • ZN619_HUMAN
  • C9JRN5_HUMAN
  • E5RJF3_HUMAN
  • E9PCD9_HUMAN
  • Q17RW3_HUMAN

Pseudogenes.org Pseudogenes for ZNF619 Gene

genes like me logo Genes that share paralogs with ZNF619: view

Variants for ZNF619 Gene

Additional dbSNP identifiers (rs#s) for ZNF619 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF619 Gene

Variant ID Type Subtype PubMed ID
nsv818137 CNV loss 17921354

Variation tolerance for ZNF619 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.08; 68.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF619 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF619

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF619 Gene

Disorders for ZNF619 Gene

No disorders were found for ZNF619 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF619 Gene

Publications for ZNF619 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L … Green MR (PLoS genetics 2012) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for ZNF619 Gene

Sources for ZNF619 Gene