Aliases for ZNF618 Gene

Aliases for ZNF618 Gene

  • Zinc Finger Protein 618 2 3 4 5
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 10 2 3
  • KIAA1952 4
  • FP13169 3
  • NEDD10 3

External Ids for ZNF618 Gene

Previous GeneCards Identifiers for ZNF618 Gene

  • GC09P112015
  • GC09P113718
  • GC09P115678
  • GC09P116638
  • GC09P086337

Summaries for ZNF618 Gene

GeneCards Summary for ZNF618 Gene

ZNF618 (Zinc Finger Protein 618) is a Protein Coding gene. Diseases associated with ZNF618 include Nut Midline Carcinoma. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is FIZ1.

UniProtKB/Swiss-Prot Summary for ZNF618 Gene

Additional gene information for ZNF618 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF618 Gene

Genomics for ZNF618 Gene

GeneHancer (GH) Regulatory Elements for ZNF618 Gene

Promoters and enhancers for ZNF618 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J113875 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.5 479 2.9 CTCF TCF12 PHF8 ZBTB10 ZBTB26 EZH2 ZNF341 RBM25 POLR2A MYC ZNF618 lnc-COL27A1-1
GH09J114080 Enhancer 1.1 Ensembl ENCODE 17.9 +205.4 205442 3.4 EP300 FOXK2 CTCF TCF12 POLR2G NCOR1 KDM6A TCF7 FOXA1 REST PRPF4 ZNF618 COL27A1 CDC26 KIF12 AMBP lnc-KIF12-1
GH09J113613 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 -260.4 -260435 4 MEF2C NR2F2 RELA TFDP1 JUND ZFHX2 YBX1 ZNF639 EBF1 IKZF1 ENSG00000282897 LOC105376222 C9orf43 ZFP37 ZNF618 POLE3 ALAD
GH09J114117 Enhancer 1.1 Ensembl ENCODE 9.7 +243.5 243479 4.8 FOXK2 POLR2G NCOR1 KDM6A TCF7 FOXA1 CUX1 ZBTB25 TGIF2 ZBTB7A PRPF4 ZNF618 COL27A1 piR-49097-107
GH09J114058 Enhancer 0.9 Ensembl ENCODE 9.9 +183.3 183343 1.6 POLR2G SIN3A TFDP1 MEF2B RBM22 MIER3 DRAP1 ZGPAT EBF1 FOSL2 PRPF4 ZNF618 CDC26 lnc-ZNF618-1 AMBP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF618 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF618

Top Transcription factor binding sites by QIAGEN in the ZNF618 gene promoter:
  • C/EBPbeta
  • Cart-1
  • NF-E2
  • NF-E2 p45
  • Pax-4a
  • POU2F1
  • POU2F1a
  • TBP

Genomic Locations for ZNF618 Gene

Genomic Locations for ZNF618 Gene
chr9:113,876,282-114,056,595
(GRCh38/hg38)
Size:
180,314 bases
Orientation:
Plus strand
chr9:116,638,562-116,818,875
(GRCh37/hg19)
Size:
180,314 bases
Orientation:
Plus strand

Genomic View for ZNF618 Gene

Genes around ZNF618 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF618 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF618 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF618 Gene

Proteins for ZNF618 Gene

  • Protein details for ZNF618 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7W0-ZN618_HUMAN
    Recommended name:
    Zinc finger protein 618
    Protein Accession:
    Q5T7W0
    Secondary Accessions:
    • B9EG82
    • Q4G0X6
    • Q5T7W1
    • Q6ZT53
    • Q7Z6B9
    • Q8TF49
    • Q96E49

    Protein attributes for ZNF618 Gene

    Size:
    954 amino acids
    Molecular mass:
    104956 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36039.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=AAH53892.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85538.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF618 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF618 Gene

Post-translational modifications for ZNF618 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF618 Gene

Domains & Families for ZNF618 Gene

Gene Families for ZNF618 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF618 Gene

Suggested Antigen Peptide Sequences for ZNF618 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 618 (B1ALC2_HUMAN)
  • ZNF618 protein (B9EG82_HUMAN)
  • Zinc finger protein 618 (ZN618_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T7W0

UniProtKB/Swiss-Prot:

ZN618_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF618: view

Function for ZNF618 Gene

Molecular function for ZNF618 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF618 Gene

Gene Ontology (GO) - Molecular Function for ZNF618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF618: view
genes like me logo Genes that share phenotypes with ZNF618: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF618 Gene

Localization for ZNF618 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF618 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF618 gene
Compartment Confidence
nucleus 4
extracellular 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF618: view

Pathways & Interactions for ZNF618 Gene

PathCards logo

SuperPathways for ZNF618 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF618 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF618 Gene

Drugs & Compounds for ZNF618 Gene

No Compound Related Data Available

Transcripts for ZNF618 Gene

mRNA/cDNA for ZNF618 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF618 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2: -
SP3:
SP4: -
SP5: - - -
SP6:

Relevant External Links for ZNF618 Gene

GeneLoc Exon Structure for
ZNF618

Expression for ZNF618 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF618 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF618 Gene

This gene is overexpressed in Platelet (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF618 Gene



Protein tissue co-expression partners for ZNF618 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF618

SOURCE GeneReport for Unigene cluster for ZNF618 Gene:

Hs.349208

Evidence on tissue expression from TISSUES for ZNF618 Gene

  • Eye(4.3)
  • Nervous system(4.3)
  • Kidney(4.2)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with ZNF618: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF618 Gene

Orthologs for ZNF618 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF618 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF618 31
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF618 31
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp618 17 31 30
  • 88.26 (n)
dog
(Canis familiaris)
Mammalia ZNF618 31
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF618 31
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF618 31
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF618 31 30
  • 80.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF618 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13236 30
zebrafish
(Danio rerio)
Actinopterygii znf618 30
  • 62.36 (n)
ZNF618 31
  • 54 (a)
OneToOne
Species where no ortholog for ZNF618 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF618 Gene

ENSEMBL:
Gene Tree for ZNF618 (if available)
TreeFam:
Gene Tree for ZNF618 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF618: view image

Paralogs for ZNF618 Gene

Paralogs for ZNF618 Gene

genes like me logo Genes that share paralogs with ZNF618: view

Variants for ZNF618 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF618 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
717654 Benign: not provided 114,049,174(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF618 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF618 Gene

Variant ID Type Subtype PubMed ID
dgv12855n54 CNV gain 21841781
dgv33e196 CNV duplication 17116639
dgv945n27 CNV gain 19166990
esv1406827 CNV insertion 17803354
esv2738960 CNV deletion 23290073
esv2761285 CNV gain 21179565
esv3621549 CNV gain 21293372
esv3621551 CNV loss 21293372
nsv1075670 CNV deletion 25765185
nsv1144288 CNV deletion 24896259
nsv415373 CNV deletion 16902084
nsv471319 CNV gain 18288195
nsv521361 CNV gain 19592680
nsv521362 CNV loss 19592680
nsv522429 CNV gain 19592680
nsv523823 CNV loss 19592680
nsv528822 CNV gain 19592680
nsv825055 CNV gain 20364138
nsv825056 CNV gain 20364138

Variation tolerance for ZNF618 Gene

Residual Variation Intolerance Score: 3.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF618 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF618

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF618 Gene

Disorders for ZNF618 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF618 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nut midline carcinoma
  • nuclear protein in testis midline carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF618

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF618: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF618 Gene

Publications for ZNF618 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 54
  2. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 41 54
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 41 54
  4. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A … Vieira AR (American journal of medical genetics. Part A 2010) 3 41 54
  5. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PMID: 19724895) Yoshida T … Yamada Y (International journal of molecular medicine 2009) 3 41 54

Products for ZNF618 Gene

Sources for ZNF618 Gene