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Aliases for ZNF618 Gene

Aliases for ZNF618 Gene

  • Zinc Finger Protein 618 2 3 5
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 10 2 3
  • KIAA1952 4
  • FP13169 3
  • NEDD10 3

External Ids for ZNF618 Gene

Previous GeneCards Identifiers for ZNF618 Gene

  • GC09P112015
  • GC09P113718
  • GC09P115678
  • GC09P116638
  • GC09P086337

Summaries for ZNF618 Gene

GeneCards Summary for ZNF618 Gene

ZNF618 (Zinc Finger Protein 618) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF618 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF618 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF618 Gene

Genomics for ZNF618 Gene

GeneHancer (GH) Regulatory Elements for ZNF618 Gene

Promoters and enhancers for ZNF618 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I113875 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 +0.5 519 2.4 CTCF ZNF384 ZNF2 RAD21 YY1 ZNF335 GLIS2 POLR2A BRD9 PATZ1 ZNF618 GC09P114664
GH09I114586 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.2 +714.0 713966 7.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ATP6V1G1 WHRN ZNF618 ENSG00000201749 COL27A1 TMEM268 TNFSF8 AKNA GC09P114599 PIR33481
GH09I113150 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.2 -722.8 -722798 6.2 PKNOX1 ATF1 ZFP64 ARID4B SIN3A BRCA1 ZNF48 ETS1 ZNF121 GLIS2 SLC31A2 PIR43385 PRPF4 ZNF618 COL27A1 FKBP15 BSPRY LOC105376223 WDR31 SNX30
GH09I114501 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.7 +627.5 627490 5 ATF1 FOXA2 ARID4B SIN3A DMAP1 ZNF48 ZNF766 ZNF143 FOS ATF7 WHRN ZNF618 LOC105376228
GH09I113695 Enhancer 0.8 FANTOM5 ENCODE 16.3 -180.1 -180132 1.4 MAFF JUND ZNF316 ZNF140 MAFG MAFK EMSY ZNF618 PRPF4 FKBP15 BSPRY LOC105376223 LOC100288542
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF618 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF618 gene promoter:

Genomic Locations for ZNF618 Gene

Genomic Locations for ZNF618 Gene
180,314 bases
Plus strand

Genomic View for ZNF618 Gene

Genes around ZNF618 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF618 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF618 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF618 Gene

Proteins for ZNF618 Gene

  • Protein details for ZNF618 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 618
    Protein Accession:
    Secondary Accessions:
    • B9EG82
    • Q4G0X6
    • Q5T7W1
    • Q6ZT53
    • Q7Z6B9
    • Q8TF49
    • Q96E49

    Protein attributes for ZNF618 Gene

    954 amino acids
    Molecular mass:
    104956 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH36039.1; Type=Erroneous termination; Positions=241; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=AAH53892.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85538.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF618 Gene


neXtProt entry for ZNF618 Gene

Post-translational modifications for ZNF618 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF618 Gene

Domains & Families for ZNF618 Gene

Gene Families for ZNF618 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF618 Gene

Suggested Antigen Peptide Sequences for ZNF618 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF618: view

Function for ZNF618 Gene

Molecular function for ZNF618 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF618 Gene

Gene Ontology (GO) - Molecular Function for ZNF618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF618: view

Phenotypes for ZNF618 Gene

GenomeRNAi human phenotypes for ZNF618:
genes like me logo Genes that share phenotypes with ZNF618: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF618 Gene

Localization for ZNF618 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF618 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF618 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF618: view

Pathways & Interactions for ZNF618 Gene

SuperPathways for ZNF618 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF618: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF618 Gene

Drugs & Compounds for ZNF618 Gene

No Compound Related Data Available

Transcripts for ZNF618 Gene

Unigene Clusters for ZNF618 Gene

Zinc finger protein 618:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF618 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2: -
SP4: -
SP5: - - -

Relevant External Links for ZNF618 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF618 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF618 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF618 Gene

This gene is overexpressed in Platelet (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF618 Gene

Protein tissue co-expression partners for ZNF618 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF618 Gene:


SOURCE GeneReport for Unigene cluster for ZNF618 Gene:


Evidence on tissue expression from TISSUES for ZNF618 Gene

  • Eye(4.3)
  • Nervous system(4.3)
  • Kidney(4.2)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with ZNF618: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF618 Gene

Orthologs for ZNF618 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF618 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF618 34
  • 100 (a)
(Bos Taurus)
Mammalia ZNF618 34
  • 89 (a)
(Mus musculus)
Mammalia Zfp618 33 16 34
  • 88.26 (n)
(Canis familiaris)
Mammalia ZNF618 34
  • 87 (a)
(Monodelphis domestica)
Mammalia ZNF618 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF618 34
  • 80 (a)
(Gallus gallus)
Aves ZNF618 33 34
  • 80.21 (n)
(Anolis carolinensis)
Reptilia ZNF618 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13236 33
(Danio rerio)
Actinopterygii znf618 33
  • 62.36 (n)
ZNF618 34
  • 54 (a)
Species where no ortholog for ZNF618 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF618 Gene

Gene Tree for ZNF618 (if available)
Gene Tree for ZNF618 (if available)

Paralogs for ZNF618 Gene

No data available for Paralogs for ZNF618 Gene

Variants for ZNF618 Gene

Sequence variations from dbSNP and Humsavar for ZNF618 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000001308 -- 114,053,722(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000013461 -- 113,992,290(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000015881 -- 113,970,507(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000041080 -- 114,030,918(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000046537 -- 113,906,209(+) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF618 Gene

Variant ID Type Subtype PubMed ID
nsv471319 CNV gain 18288195
nsv521361 CNV gain 19592680
nsv521362 CNV loss 19592680
nsv522429 CNV gain 19592680
nsv523823 CNV loss 19592680
nsv528822 CNV gain 19592680
nsv825055 CNV gain 20364138
nsv415373 CNV deletion 16902084
nsv1144288 CNV deletion 24896259
nsv1075670 CNV deletion 25765185
esv3621551 CNV loss 21293372
esv3621549 CNV gain 21293372
esv2761285 CNV gain 21179565
esv2738960 CNV deletion 23290073
esv1406827 CNV insertion 17803354
dgv945n27 CNV gain 19166990
dgv33e196 CNV duplication 17116639
dgv12855n54 CNV gain 21841781
nsv825056 CNV gain 20364138

Variation tolerance for ZNF618 Gene

Residual Variation Intolerance Score: 3.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF618 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF618 Gene

Disorders for ZNF618 Gene

Additional Disease Information for ZNF618

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF618 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF618 Gene

Publications for ZNF618 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58
  4. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A … Vieira AR (American journal of medical genetics. Part A 2010) 3 44 58
  5. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PMID: 19724895) Yoshida T … Yamada Y (International journal of molecular medicine 2009) 3 44 58

Products for ZNF618 Gene

Sources for ZNF618 Gene

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