Aliases for ZNF616 Gene

Aliases for ZNF616 Gene

  • Zinc Finger Protein 616 2 3 4 5

External Ids for ZNF616 Gene

Previous GeneCards Identifiers for ZNF616 Gene

  • GC19M057310
  • GC19M057314
  • GC19M052617
  • GC19M048948

Summaries for ZNF616 Gene

GeneCards Summary for ZNF616 Gene

ZNF616 (Zinc Finger Protein 616) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF28.

UniProtKB/Swiss-Prot Summary for ZNF616 Gene

Additional gene information for ZNF616 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF616 Gene

Genomics for ZNF616 Gene

GeneHancer (GH) Regulatory Elements for ZNF616 Gene

Promoters and enhancers for ZNF616 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J052137 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 535.3 +0.4 394 3.5 ZBTB40 CTCF SIN3A NRF1 MYC POLR2G USF1 SP1 PHB2 ZFX ZNF616 ZNF137P ZNF160 ZNF350 ZNF808 ENSG00000268970 ZNF600 ZNF816 ZNF836 ZNF577
GH19J052138 Promoter 0.3 EPDnew 500.7 +2.2 2190 0.1 ZNF616 ZNF432 ZNF350 ZNF615 ZNF649 RF01210-190 ENSG00000267827
GH19J051358 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 55.2 +776.1 776136 11.2 EP300 FOXK2 ZBTB40 CTCF NRF1 TCF12 POLR2G SP1 NCOR1 GTF2E2 ETFB ENSG00000268520 CLDND2 ZNF841 ZNF616 ZNF175 ZNF766 POLD1 ZNF577 ZNF836
GH19J051687 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 47.1 +449.4 449447 6.9 EP300 CTCF TCF12 NCOR1 BCLAF1 RBAK GTF2E2 TEAD4 PHB2 ZFX SPACA6 ZNF808 ZNF137P ZNF766 ZNF175 ZNF577 ZNF841 ZNF616 ENSG00000269825 ENSG00000268970
GH19J052142 Enhancer 0.2 ENCODE 500.7 -1.8 -1807 0 ENSG00000268458 RPL37P23 ZNF616 lnc-PPP2R1A-2 ENSG00000267827
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF616 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF616

Top Transcription factor binding sites by QIAGEN in the ZNF616 gene promoter:
  • AREB6
  • C/EBPalpha
  • Egr-3
  • HTF
  • IRF-1
  • NRF-2
  • Pax-2
  • Pax-2a
  • Pax-2b
  • ZID

Genomic Locations for ZNF616 Gene

Genomic Locations for ZNF616 Gene
chr19:52,113,091-52,139,938
(GRCh38/hg38)
Size:
26,848 bases
Orientation:
Minus strand
chr19:52,616,344-52,643,191
(GRCh37/hg19)
Size:
26,848 bases
Orientation:
Minus strand

Genomic View for ZNF616 Gene

Genes around ZNF616 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF616 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF616 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF616 Gene

Proteins for ZNF616 Gene

  • Protein details for ZNF616 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08AN1-ZN616_HUMAN
    Recommended name:
    Zinc finger protein 616
    Protein Accession:
    Q08AN1
    Secondary Accessions:
    • B3KRV1
    • Q0P658
    • Q658V7

    Protein attributes for ZNF616 Gene

    Size:
    781 amino acids
    Molecular mass:
    90273 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF616 Gene

Post-translational modifications for ZNF616 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF616 Gene

No data available for DME Specific Peptides for ZNF616 Gene

Domains & Families for ZNF616 Gene

Gene Families for ZNF616 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF616 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF616 Gene

GenScript: Design optimal peptide antigens:
  • ZNF616 protein (Q08AN0_HUMAN)
  • Zinc finger protein 616 (ZN616_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q08AN1

UniProtKB/Swiss-Prot:

ZN616_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF616: view

Function for ZNF616 Gene

Molecular function for ZNF616 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF616 Gene

Gene Ontology (GO) - Molecular Function for ZNF616 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF616: view
genes like me logo Genes that share phenotypes with ZNF616: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF616

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF616 Gene

Localization for ZNF616 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF616 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF616 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF616 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF616: view

Pathways & Interactions for ZNF616 Gene

genes like me logo Genes that share pathways with ZNF616: view

Pathways by source for ZNF616 Gene

2 Reactome pathways for ZNF616 Gene
1 KEGG pathway for ZNF616 Gene

Gene Ontology (GO) - Biological Process for ZNF616 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF616: view

No data available for SIGNOR curated interactions for ZNF616 Gene

Drugs & Compounds for ZNF616 Gene

No Compound Related Data Available

Transcripts for ZNF616 Gene

mRNA/cDNA for ZNF616 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF616

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF616 Gene

No ASD Table

Relevant External Links for ZNF616 Gene

GeneLoc Exon Structure for
ZNF616

Expression for ZNF616 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF616 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF616 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF616

SOURCE GeneReport for Unigene cluster for ZNF616 Gene:

Hs.645225

Evidence on tissue expression from TISSUES for ZNF616 Gene

  • Nervous system(4.3)
  • Intestine(4.1)
  • Stomach(4.1)
genes like me logo Genes that share expression patterns with ZNF616: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF616 Gene

Orthologs for ZNF616 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF616 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF616 31 30
  • 99.02 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gm13247 30
  • 69.37 (n)
Zfp51 31
  • 39 (a)
ManyToMany
Zfp992 17
cow
(Bos Taurus)
Mammalia LOC617476 30
  • 66.9 (n)
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
CSA.1668 31
  • 33 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
Species where no ortholog for ZNF616 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF616 Gene

ENSEMBL:
Gene Tree for ZNF616 (if available)
TreeFam:
Gene Tree for ZNF616 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF616: view image

Paralogs for ZNF616 Gene

Paralogs for ZNF616 Gene

(517) SIMAP similar genes for ZNF616 Gene using alignment to 5 proteins:

  • ZN616_HUMAN
  • M0QXF0_HUMAN
  • M0QYU5_HUMAN
  • M0R0C2_HUMAN
  • Q08AN0_HUMAN
genes like me logo Genes that share paralogs with ZNF616: view

Variants for ZNF616 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF616 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs35582075 - p.Pro50Ser
rs3764537 - p.His451Arg

Additional dbSNP identifiers (rs#s) for ZNF616 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF616 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv6523n54 CNV gain 21841781
esv2718780 CNV deletion 23290073
esv3644684 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv2535 CNV deletion 18451855
nsv833872 CNV loss 17160897
nsv960859 CNV duplication 23825009

Variation tolerance for ZNF616 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF616 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF616

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF616 Gene

Disorders for ZNF616 Gene

Additional Disease Information for ZNF616

No disorders were found for ZNF616 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF616 Gene

Publications for ZNF616 Gene

No publications were found for ZNF616 Gene.

Products for ZNF616 Gene

Sources for ZNF616 Gene