Aliases for ZNF615 Gene

Aliases for ZNF615 Gene

  • Zinc Finger Protein 615 2 3 4 5

External Ids for ZNF615 Gene

Previous GeneCards Identifiers for ZNF615 Gene

  • GC19M057188
  • GC19M057191
  • GC19M057193
  • GC19M057194
  • GC19M057195
  • GC19M057196
  • GC19M057197
  • GC19M057198
  • GC19M057199
  • GC19M052469
  • GC19M052494

Summaries for ZNF615 Gene

GeneCards Summary for ZNF615 Gene

ZNF615 (Zinc Finger Protein 615) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF432.

UniProtKB/Swiss-Prot Summary for ZNF615 Gene

Additional gene information for ZNF615 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF615 Gene

Genomics for ZNF615 Gene

GeneHancer (GH) Regulatory Elements for ZNF615 Gene

Promoters and enhancers for ZNF615 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF615 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF615

Top Transcription factor binding sites by QIAGEN in the ZNF615 gene promoter:
  • Bach1

Genomic Locations for ZNF615 Gene

Genomic Locations for ZNF615 Gene
chr19:51,991,332-52,008,238
(GRCh38/hg38)
Size:
16,907 bases
Orientation:
Minus strand
chr19:52,494,585-52,511,483
(GRCh37/hg19)
Size:
16,899 bases
Orientation:
Minus strand

Genomic View for ZNF615 Gene

Genes around ZNF615 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF615 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF615 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF615 Gene

Proteins for ZNF615 Gene

  • Protein details for ZNF615 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8J6-ZN615_HUMAN
    Recommended name:
    Zinc finger protein 615
    Protein Accession:
    Q8N8J6
    Secondary Accessions:
    • B7ZKW9
    • Q2M2Y6
    • Q5CZB0
    • Q6ZMT7
    • Q6ZRB3

    Protein attributes for ZNF615 Gene

    Size:
    731 amino acids
    Molecular mass:
    83739 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC87399.1; Type=Miscellaneous discrepancy; Note=aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF615 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF615 Gene

Post-translational modifications for ZNF615 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF615 Gene

Domains & Families for ZNF615 Gene

Gene Families for ZNF615 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF615 Gene

Suggested Antigen Peptide Sequences for ZNF615 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 615 (ZN615_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N8J6

UniProtKB/Swiss-Prot:

ZN615_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF615: view

Function for ZNF615 Gene

Molecular function for ZNF615 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF615 Gene

Gene Ontology (GO) - Molecular Function for ZNF615 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF615: view
genes like me logo Genes that share phenotypes with ZNF615: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF615 Gene

Localization for ZNF615 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF615 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF615 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF615 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF615: view

Pathways & Interactions for ZNF615 Gene

genes like me logo Genes that share pathways with ZNF615: view

Pathways by source for ZNF615 Gene

2 Reactome pathways for ZNF615 Gene
1 KEGG pathway for ZNF615 Gene

Interacting Proteins for ZNF615 Gene

;

Gene Ontology (GO) - Biological Process for ZNF615 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF615: view

No data available for SIGNOR curated interactions for ZNF615 Gene

Drugs & Compounds for ZNF615 Gene

No Compound Related Data Available

Transcripts for ZNF615 Gene

mRNA/cDNA for ZNF615 Gene

9 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF615 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - -
SP10:
SP11: -

Relevant External Links for ZNF615 Gene

GeneLoc Exon Structure for
ZNF615

Expression for ZNF615 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF615 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF615

SOURCE GeneReport for Unigene cluster for ZNF615 Gene:

Hs.368355

Evidence on tissue expression from TISSUES for ZNF615 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ZNF615: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF615 Gene

Orthologs for ZNF615 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF615 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF615 31 30
  • 99.18 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF615 31 30
  • 88.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF432 31
  • 60 (a)
OneToOne
Species where no ortholog for ZNF615 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF615 Gene

ENSEMBL:
Gene Tree for ZNF615 (if available)
TreeFam:
Gene Tree for ZNF615 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF615: view image

Paralogs for ZNF615 Gene

Paralogs for ZNF615 Gene

(556) SIMAP similar genes for ZNF615 Gene using alignment to 6 proteins:

  • ZN615_HUMAN
  • H9KV89_HUMAN
  • M0QZR2_HUMAN
  • M0QZZ4_HUMAN
  • M0R0F8_HUMAN
  • M0R130_HUMAN
genes like me logo Genes that share paralogs with ZNF615: view

Variants for ZNF615 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF615 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10500311 - p.Thr129Met
rs16983353 - p.Arg727Lys
rs1978717 - p.Thr360Ile

Additional dbSNP identifiers (rs#s) for ZNF615 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF615 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
nsv1109208 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv580001 CNV gain 21841781
nsv580006 CNV loss 21841781
nsv833872 CNV loss 17160897
nsv963067 CNV duplication 23825009

Variation tolerance for ZNF615 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.10; 92.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF615 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF615

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF615 Gene

Disorders for ZNF615 Gene

Additional Disease Information for ZNF615

No disorders were found for ZNF615 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF615 Gene

Publications for ZNF615 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 54
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54

Products for ZNF615 Gene

Sources for ZNF615 Gene