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Aliases for ZNF614 Gene

Aliases for ZNF614 Gene

  • Zinc Finger Protein 614 2 3 5

External Ids for ZNF614 Gene

Previous GeneCards Identifiers for ZNF614 Gene

  • GC19M057208
  • GC19M057209
  • GC19M057210
  • GC19M057211
  • GC19M057212
  • GC19M057213
  • GC19M057214
  • GC19M057215
  • GC19M052516
  • GC19M048847

Summaries for ZNF614 Gene

GeneCards Summary for ZNF614 Gene

ZNF614 (Zinc Finger Protein 614) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF615.

UniProtKB/Swiss-Prot for ZNF614 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF614 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF614 Gene

Genomics for ZNF614 Gene

GeneHancer (GH) Regulatory Elements for ZNF614 Gene

Promoters and enhancers for ZNF614 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I052026 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 564.4 +2.3 2327 3 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF614 ZNF841 ZNF613 ZNF137P ZNF432 ENSG00000269483 ENSG00000268970 ZNF701 ZNF611 ZNF528
GH19I051393 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 47.7 +635.2 635193 2.8 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A IRF4 YY1 POLR2B ENSG00000268889 LOC105372446 ZNF841 ZNF766 ZNF577 ZNF616 ZNF175 ZNF836 ZNF432 ZNF614
GH19I051687 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 27.5 +339.7 339749 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 ZNF137P ZNF808 ZNF841 ZNF616 ZNF766 ZNF577 ENSG00000268970 ZNF836 ENSG00000269825 ZNF175
GH19I051360 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 14 +665.3 665297 8.5 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A MEF2D ETFB CLDND2 ENSG00000268520 ZNF616 POLD1 ZNF766 ZNF836 ZNF841 ZNF577 ZNF175
GH19I052188 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.8 -160.1 -160078 4.4 HDGF PKNOX1 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 POLR2B PPP2R1A ZNF766 ZNF175 ENSG00000269483 ZNF614 ZNF415 ZNF528 ZNF578 ENSG00000268225 ZNF160
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF614 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF614 Gene

Genomic Locations for ZNF614 Gene
chr19:52,012,765-52,030,240
(GRCh38/hg38)
Size:
17,476 bases
Orientation:
Minus strand
chr19:52,516,018-52,533,493
(GRCh37/hg19)

Genomic View for ZNF614 Gene

Genes around ZNF614 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF614 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF614 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF614 Gene

Proteins for ZNF614 Gene

  • Protein details for ZNF614 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N883-ZN614_HUMAN
    Recommended name:
    Zinc finger protein 614
    Protein Accession:
    Q8N883
    Secondary Accessions:
    • Q494T8
    • Q8TCF4
    • Q9BSN8

    Protein attributes for ZNF614 Gene

    Size:
    585 amino acids
    Molecular mass:
    67215 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF614 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF614 Gene

Post-translational modifications for ZNF614 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF614 Gene

No data available for DME Specific Peptides for ZNF614 Gene

Domains & Families for ZNF614 Gene

Gene Families for ZNF614 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF614 Gene

Suggested Antigen Peptide Sequences for ZNF614 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N883

UniProtKB/Swiss-Prot:

ZN614_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF614: view

Function for ZNF614 Gene

Molecular function for ZNF614 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF614 Gene

Gene Ontology (GO) - Molecular Function for ZNF614 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 22458338
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF614: view
genes like me logo Genes that share phenotypes with ZNF614: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF614 Gene

Localization for ZNF614 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF614 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF614 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF614 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF614: view

Pathways & Interactions for ZNF614 Gene

SuperPathways for ZNF614 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF614: view

Pathways by source for ZNF614 Gene

2 Reactome pathways for ZNF614 Gene

Gene Ontology (GO) - Biological Process for ZNF614 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF614: view

No data available for SIGNOR curated interactions for ZNF614 Gene

Drugs & Compounds for ZNF614 Gene

No Compound Related Data Available

Transcripts for ZNF614 Gene

Unigene Clusters for ZNF614 Gene

Zinc finger protein 614:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF614 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7
SP1: - - - -
SP2: - -
SP3: - - - -
SP4:

Relevant External Links for ZNF614 Gene

GeneLoc Exon Structure for
ZNF614
ECgene alternative splicing isoforms for
ZNF614

Expression for ZNF614 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF614 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF614 Gene:

ZNF614

SOURCE GeneReport for Unigene cluster for ZNF614 Gene:

Hs.292336

Evidence on tissue expression from TISSUES for ZNF614 Gene

  • Spleen(4.2)
genes like me logo Genes that share expression patterns with ZNF614: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF614 Gene

Orthologs for ZNF614 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF614 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF614 33 34
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia ZNF614 33 34
  • 82.02 (n)
dog
(Canis familiaris)
Mammalia ZNF614 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 45 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 37 (a)
OneToMany
Species where no ortholog for ZNF614 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF614 Gene

ENSEMBL:
Gene Tree for ZNF614 (if available)
TreeFam:
Gene Tree for ZNF614 (if available)

Paralogs for ZNF614 Gene

Paralogs for ZNF614 Gene

(496) SIMAP similar genes for ZNF614 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ZNF614 Gene

genes like me logo Genes that share paralogs with ZNF614: view

Variants for ZNF614 Gene

Sequence variations from dbSNP and Humsavar for ZNF614 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000049430 -- 52,025,036(-) G/A intron_variant
rs1000101543 -- 52,025,367(-) T/C intron_variant
rs1000291812 -- 52,021,633(-) T/C intron_variant
rs1000302024 -- 52,028,401(-) G/C 5_prime_UTR_variant
rs1000402411 -- 52,021,894(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF614 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
esv3583506 CNV loss 25503493
esv3644683 CNV loss 21293372
nsv1140251 OTHER inversion 24896259
nsv580001 CNV gain 21841781
nsv580006 CNV loss 21841781
nsv833872 CNV loss 17160897

Variation tolerance for ZNF614 Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF614 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF614

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF614 Gene

Disorders for ZNF614 Gene

Additional Disease Information for ZNF614

No disorders were found for ZNF614 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF614 Gene

Publications for ZNF614 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q … Chinnaiyan AM (Nature communications 2014) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZNF614 Gene

Sources for ZNF614 Gene

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