Aliases for ZNF613 Gene

Aliases for ZNF613 Gene

  • Zinc Finger Protein 613 2 3 4 5
  • FLJ13590 2
  • ZNF613 5

External Ids for ZNF613 Gene

Previous GeneCards Identifiers for ZNF613 Gene

  • GC19P057123
  • GC19P057125
  • GC19P052430
  • GC19P048761
  • GC19P051879

Summaries for ZNF613 Gene

GeneCards Summary for ZNF613 Gene

ZNF613 (Zinc Finger Protein 613) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF350.

UniProtKB/Swiss-Prot Summary for ZNF613 Gene

Additional gene information for ZNF613 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF613 Gene

Genomics for ZNF613 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF613 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF613 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF613

Top Transcription factor binding sites by QIAGEN in the ZNF613 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun

Genomic Locations for ZNF613 Gene

Genomic Locations for ZNF613 Gene
chr19:51,927,147-51,948,759
(GRCh38/hg38)
Size:
21,613 bases
Orientation:
Plus strand
chr19:52,430,400-52,452,012
(GRCh37/hg19)
Size:
21,613 bases
Orientation:
Plus strand

Genomic View for ZNF613 Gene

Genes around ZNF613 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF613 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF613 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF613 Gene

Proteins for ZNF613 Gene

  • Protein details for ZNF613 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PF04-ZN613_HUMAN
    Recommended name:
    Zinc finger protein 613
    Protein Accession:
    Q6PF04
    Secondary Accessions:
    • Q96SS9

    Protein attributes for ZNF613 Gene

    Size:
    617 amino acids
    Molecular mass:
    70143 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF613 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF613 Gene

Post-translational modifications for ZNF613 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF613 Gene

Domains & Families for ZNF613 Gene

Gene Families for ZNF613 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF613 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF613 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 613 (ZN613_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6PF04

UniProtKB/Swiss-Prot:

ZN613_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF613: view

Function for ZNF613 Gene

Molecular function for ZNF613 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF613 Gene

Gene Ontology (GO) - Molecular Function for ZNF613 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF613: view
genes like me logo Genes that share phenotypes with ZNF613: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF613

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF613 Gene

Localization for ZNF613 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF613 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF613 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF613 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA 21873635
genes like me logo Genes that share ontologies with ZNF613: view

Pathways & Interactions for ZNF613 Gene

genes like me logo Genes that share pathways with ZNF613: view

Pathways by source for ZNF613 Gene

2 Reactome pathways for ZNF613 Gene
1 KEGG pathway for ZNF613 Gene

Interacting Proteins for ZNF613 Gene

Gene Ontology (GO) - Biological Process for ZNF613 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF613: view

No data available for SIGNOR curated interactions for ZNF613 Gene

Drugs & Compounds for ZNF613 Gene

No Compound Related Data Available

Transcripts for ZNF613 Gene

mRNA/cDNA for ZNF613 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF613

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF613 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - -
SP7: - - - -
SP8:
SP9: - - - - - -

Relevant External Links for ZNF613 Gene

GeneLoc Exon Structure for
ZNF613

Expression for ZNF613 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF613 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF613

SOURCE GeneReport for Unigene cluster for ZNF613 Gene:

Hs.183390
genes like me logo Genes that share expression patterns with ZNF613: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF613 Gene

Orthologs for ZNF613 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF613 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF613 30 31
  • 99.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF613 30 31
  • 84.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF613 30 31
  • 82.36 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp157 30 17
  • 59.86 (n)
Rat
(Rattus norvegicus)
Mammalia Zfp157 30
  • 59.48 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 46 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 39 (a)
OneToMany
Species where no ortholog for ZNF613 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF613 Gene

ENSEMBL:
Gene Tree for ZNF613 (if available)
TreeFam:
Gene Tree for ZNF613 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF613: view image

Paralogs for ZNF613 Gene

(513) SIMAP similar genes for ZNF613 Gene using alignment to 3 proteins:

  • ZN613_HUMAN
  • M0QX19_HUMAN
  • M0R2C1_HUMAN
genes like me logo Genes that share paralogs with ZNF613: view

Variants for ZNF613 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF613 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs16983243 - p.Ile135Arg
rs16983253 - p.Asp611Val
rs17854933 - p.Asp84Asn
rs33998555 - p.Ser163Phe
rs8106409 - p.Lys93Glu

Additional dbSNP identifiers (rs#s) for ZNF613 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF613 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
esv3644680 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv580001 CNV gain 21841781
nsv580005 CNV loss 21841781
nsv833872 CNV loss 17160897

Variation tolerance for ZNF613 Gene

Residual Variation Intolerance Score: 49.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF613 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF613

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF613 Gene

Disorders for ZNF613 Gene

No disorders were found for ZNF613 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF613 Gene

Publications for ZNF613 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF613 Gene

Sources for ZNF613 Gene