Aliases for ZNF610 Gene

Aliases for ZNF610 Gene

  • Zinc Finger Protein 610 2 3 4 5
  • Zink Finger Protein 3
  • FLJ36040 2
  • ZNF610 5

External Ids for ZNF610 Gene

Previous GeneCards Identifiers for ZNF610 Gene

  • GC19P057540
  • GC19P052839
  • GC19P049169

Summaries for ZNF610 Gene

GeneCards Summary for ZNF610 Gene

ZNF610 (Zinc Finger Protein 610) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF480.

UniProtKB/Swiss-Prot Summary for ZNF610 Gene

Additional gene information for ZNF610 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF610 Gene

Genomics for ZNF610 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF610 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF610 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF610

Top Transcription factor binding sites by QIAGEN in the ZNF610 gene promoter:
  • ATF6
  • HTF

Genomic Locations for ZNF610 Gene

Genomic Locations for ZNF610 Gene
chr19:52,336,243-52,367,778
(GRCh38/hg38)
Size:
31,536 bases
Orientation:
Plus strand
chr19:52,839,498-52,871,031
(GRCh37/hg19)
Size:
31,534 bases
Orientation:
Plus strand

Genomic View for ZNF610 Gene

Genes around ZNF610 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF610 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF610 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF610 Gene

Proteins for ZNF610 Gene

  • Protein details for ZNF610 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9Z0-ZN610_HUMAN
    Recommended name:
    Zinc finger protein 610
    Protein Accession:
    Q8N9Z0
    Secondary Accessions:
    • A8K4C3
    • Q86YH8
    • Q8NDS9

    Protein attributes for ZNF610 Gene

    Size:
    462 amino acids
    Molecular mass:
    53489 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF610 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF610 Gene

Post-translational modifications for ZNF610 Gene

  • Ubiquitination at Lys412
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF610 Gene

Domains & Families for ZNF610 Gene

Gene Families for ZNF610 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF610 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF610 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 610 (ZN610_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N9Z0

UniProtKB/Swiss-Prot:

ZN610_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF610: view

Function for ZNF610 Gene

Molecular function for ZNF610 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF610 Gene

Gene Ontology (GO) - Molecular Function for ZNF610 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF610: view
genes like me logo Genes that share phenotypes with ZNF610: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF610

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF610 Gene

Localization for ZNF610 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF610 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF610 gene
Compartment Confidence
nucleus 4
mitochondrion 0
peroxisome 0
endoplasmic reticulum 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF610 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF610: view

Pathways & Interactions for ZNF610 Gene

genes like me logo Genes that share pathways with ZNF610: view

Pathways by source for ZNF610 Gene

2 Reactome pathways for ZNF610 Gene
1 KEGG pathway for ZNF610 Gene

Gene Ontology (GO) - Biological Process for ZNF610 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF610: view

No data available for SIGNOR curated interactions for ZNF610 Gene

Drugs & Compounds for ZNF610 Gene

No Compound Related Data Available

Transcripts for ZNF610 Gene

mRNA/cDNA for ZNF610 Gene

4 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF610

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF610 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for ZNF610 Gene

GeneLoc Exon Structure for
ZNF610

Expression for ZNF610 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF610 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)
  • Eye (Sensory Organs)

Protein differential expression in normal tissues from HIPED for ZNF610 Gene

This gene is overexpressed in Heart (51.6) and Platelet (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF610 Gene



Protein tissue co-expression partners for ZNF610 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF610

SOURCE GeneReport for Unigene cluster for ZNF610 Gene:

Hs.147025

Evidence on tissue expression from TISSUES for ZNF610 Gene

  • Nervous system(4.2)
  • Skin(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZNF610: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF610 Gene

Orthologs for ZNF610 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF610 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF610 30
  • 99.28 (n)
-- 31
  • 87 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 41 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 32 (a)
ManyToMany
Species where no ortholog for ZNF610 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF610 Gene

ENSEMBL:
Gene Tree for ZNF610 (if available)
TreeFam:
Gene Tree for ZNF610 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF610: view image

Paralogs for ZNF610 Gene

(501) SIMAP similar genes for ZNF610 Gene using alignment to 2 proteins:

  • ZN610_HUMAN
  • M0QYM6_HUMAN

Pseudogenes.org Pseudogenes for ZNF610 Gene

genes like me logo Genes that share paralogs with ZNF610: view

Variants for ZNF610 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF610 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2241586 - p.Ala131Ser
rs321937 - p.Arg216Pro
rs3815905 - p.Val104Met
rs7343101 - p.Arg298Ile

Additional dbSNP identifiers (rs#s) for ZNF610 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF610 Gene

Variant ID Type Subtype PubMed ID
esv21813 CNV gain 19812545
esv2600634 CNV deletion 19546169
esv2660483 CNV deletion 23128226
esv2671354 CNV deletion 23128226
esv3644690 CNV loss 21293372
nsv1140251 OTHER inversion 24896259
nsv2536 CNV deletion 18451855
nsv458742 CNV loss 19166990
nsv580008 CNV loss 21841781
nsv833873 CNV gain 17160897
nsv963069 CNV duplication 23825009

Variation tolerance for ZNF610 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF610 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF610

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF610 Gene

Disorders for ZNF610 Gene

No disorders were found for ZNF610 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF610 Gene

Publications for ZNF610 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF610 Gene

Sources for ZNF610 Gene