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Aliases for ZNF609 Gene

Aliases for ZNF609 Gene

  • Zinc Finger Protein 609 2 3 5
  • KIAA0295 4

External Ids for ZNF609 Gene

Previous GeneCards Identifiers for ZNF609 Gene

  • GC15P062507
  • GC15P062578
  • GC15P064752
  • GC15P041616
  • GC15P064792
  • GC15P064794
  • GC15P064743
  • GC15P065399
  • GC15P065441
  • GC15P066329
  • GC15P066883
  • GC15P067412
  • GC15P067938

Summaries for ZNF609 Gene

GeneCards Summary for ZNF609 Gene

ZNF609 (Zinc Finger Protein 609) is a Protein Coding gene. An important paralog of this gene is ZNF608.

UniProtKB/Swiss-Prot for ZNF609 Gene

  • Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others.

  • Isoform 2: Involved in the regulation of myoblast proliferation during myogenesis.

Additional gene information for ZNF609 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF609 Gene

Genomics for ZNF609 Gene

GeneHancer (GH) Regulatory Elements for ZNF609 Gene

Promoters and enhancers for ZNF609 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I064459 Promoter/Enhancer 2.1 VISTA FANTOM5 Ensembl ENCODE 560.6 +0.2 247 3.7 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF609 LOC105370861 TRIP4 PARP16 SNX1 USP3 ENSG00000264937 CSNK1G1 PLEKHO2 ENSG00000259682
GH15I064499 Promoter 0.5 EPDnew 561.6 +38.6 38615 0.1 ZNF609 PIR57437 RNU6-549P ENSG00000259682
GH15I065303 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 79.8 +843.7 843729 2.2 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC GC15M065305 RNU5B-1 GC15P068442 PARP16 ZNF609 TRIP4 INTS14 PDCD7 SLC24A1 ENSG00000264937
GH15I065295 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 70.9 +836.6 836625 4.1 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 GC15P068518 RNU5A-1 PARP16 INTS14 ZNF609 TRIP4 ENSG00000264937 ENSG00000259635 PDCD7 CSNK1G1
GH15I065419 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.8 +960.7 960743 4.2 HDGF SIN3A ZNF2 ZBTB7B SP3 REST ZNF592 SMARCA4 ZSCAN16 GLIS1 IGDCC4 DIS3L ZNF609 INTS14 ENSG00000260773 PARP16 IGDCC3 ENSG00000264937 PDCD7 DENND4A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF609 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF609 gene promoter:

Genomic Locations for ZNF609 Gene

Genomic Locations for ZNF609 Gene
chr15:64,460,742-64,686,068
(GRCh38/hg38)
Size:
225,327 bases
Orientation:
Plus strand
chr15:64,752,941-64,978,267
(GRCh37/hg19)

Genomic View for ZNF609 Gene

Genes around ZNF609 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF609 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF609 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF609 Gene

Proteins for ZNF609 Gene

  • Protein details for ZNF609 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15014-ZN609_HUMAN
    Recommended name:
    Zinc finger protein 609
    Protein Accession:
    O15014
    Secondary Accessions:
    • Q0D2I2

    Protein attributes for ZNF609 Gene

    Size:
    1411 amino acids
    Molecular mass:
    151191 Da
    Quaternary structure:
    • Interacts (via N-terminus) with NIPBL. Interacts with the multiprotein complex Integrator.

    Alternative splice isoforms for ZNF609 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF609 Gene

Post-translational modifications for ZNF609 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF609 Gene

No data available for DME Specific Peptides for ZNF609 Gene

Domains & Families for ZNF609 Gene

Gene Families for ZNF609 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF609 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF609 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF609: view

No data available for UniProtKB/Swiss-Prot for ZNF609 Gene

Function for ZNF609 Gene

Molecular function for ZNF609 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others.
UniProtKB/Swiss-Prot Function:
Isoform 2: Involved in the regulation of myoblast proliferation during myogenesis.
UniProtKB/Swiss-Prot Induction:
Isoform 1: Up-regulated during neuronal differentiation in retinoic acid-treated SH-SY5Y cells (PubMed:25921068). Isoform 2: Down-regulated during myogenesis (PubMed:28344082).

Phenotypes From GWAS Catalog for ZNF609 Gene

Gene Ontology (GO) - Molecular Function for ZNF609 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF609: view

Phenotypes for ZNF609 Gene

MGI mutant phenotypes for ZNF609:
inferred from 1 alleles
GenomeRNAi human phenotypes for ZNF609:
genes like me logo Genes that share phenotypes with ZNF609: view

Animal Models for ZNF609 Gene

MGI Knock Outs for ZNF609:

Animal Model Products

CRISPR Products

miRNA for ZNF609 Gene

miRTarBase miRNAs that target ZNF609

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF609 Gene

Localization for ZNF609 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF609 Gene

Isoform 2: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF609 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF609 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 28344082
GO:0005654 nucleoplasm IDA --
GO:0032039 integrator complex ISS,IEA --
genes like me logo Genes that share ontologies with ZNF609: view

Pathways & Interactions for ZNF609 Gene

SuperPathways for ZNF609 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF609 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,ISS --
GO:0007275 multicellular organism development IEA --
GO:0007517 muscle organ development IEA --
genes like me logo Genes that share ontologies with ZNF609: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF609 Gene

Drugs & Compounds for ZNF609 Gene

No Compound Related Data Available

Transcripts for ZNF609 Gene

Unigene Clusters for ZNF609 Gene

Zinc finger protein 609:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF609 Gene

No ASD Table

Relevant External Links for ZNF609 Gene

GeneLoc Exon Structure for
ZNF609
ECgene alternative splicing isoforms for
ZNF609

Expression for ZNF609 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF609 Gene

Protein differential expression in normal tissues from HIPED for ZNF609 Gene

This gene is overexpressed in Testis (18.3), CD8 Tcells (13.7), Cerebrospinal fluid (12.3), and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF609 Gene



Protein tissue co-expression partners for ZNF609 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF609 Gene:

ZNF609

SOURCE GeneReport for Unigene cluster for ZNF609 Gene:

Hs.595451

mRNA Expression by UniProt/SwissProt for ZNF609 Gene:

O15014-ZN609_HUMAN
Tissue specificity: Isoform 1: Expressed in myoblasts and myotubes. Isoform 2: Expressed in myoblasts and myotubes, with a preference in undifferentiated myoblasts.

Evidence on tissue expression from TISSUES for ZNF609 Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Skin(4.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with ZNF609: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF609 Gene

Orthologs for ZNF609 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF609 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF609 33 34
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia ZNF609 33 34
  • 94.05 (n)
cow
(Bos Taurus)
Mammalia ZNF609 33 34
  • 93.39 (n)
mouse
(Mus musculus)
Mammalia Zfp609 33 16 34
  • 91.18 (n)
rat
(Rattus norvegicus)
Mammalia Zfp609 33
  • 90.74 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF609 34
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF609 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF609 33 34
  • 77.71 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF609 34
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18738 33
zebrafish
(Danio rerio)
Actinopterygii zgc:162740 33
  • 65.2 (n)
znf609 34
  • 60 (a)
OneToMany
ZNF609 (2 of 2) 34
  • 60 (a)
OneToMany
wufc26a02 33
fruit fly
(Drosophila melanogaster)
Insecta sbb 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
OneToMany
Species where no ortholog for ZNF609 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF609 Gene

ENSEMBL:
Gene Tree for ZNF609 (if available)
TreeFam:
Gene Tree for ZNF609 (if available)

Paralogs for ZNF609 Gene

Paralogs for ZNF609 Gene

(1) SIMAP similar genes for ZNF609 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF609: view

Variants for ZNF609 Gene

Sequence variations from dbSNP and Humsavar for ZNF609 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000001346 -- 64,642,522(+) A/G intron_variant
rs1000021495 -- 64,622,143(+) T/C intron_variant
rs1000028472 -- 64,665,686(+) G/C intron_variant
rs1000037287 -- 64,685,897(+) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000052779 -- 64,573,661(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF609 Gene

Variant ID Type Subtype PubMed ID
dgv453e199 CNV deletion 23128226
esv1105706 CNV insertion 17803354
esv1482397 CNV deletion 17803354
esv2665503 CNV deletion 23128226
esv2671821 CNV deletion 23128226
esv2749786 CNV deletion 23290073
esv3552565 CNV deletion 23714750
esv3552570 CNV deletion 23714750
esv3581745 CNV loss 25503493
esv3636735 CNV loss 21293372
esv3636736 CNV loss 21293372
esv3636737 CNV loss 21293372
esv3636738 CNV loss 21293372
esv3636739 CNV loss 21293372
nsv1070278 CNV deletion 25765185
nsv1070703 CNV deletion 25765185
nsv1127441 CNV deletion 24896259
nsv1134460 CNV deletion 24896259
nsv476506 CNV novel sequence insertion 20440878
nsv526185 CNV loss 19592680
nsv827361 CNV loss 20364138
nsv827362 CNV gain 20364138
nsv833038 CNV loss 17160897
nsv94275 CNV deletion 16902084
nsv974587 CNV duplication 23825009
nsv976944 CNV duplication 23825009
nsv984084 CNV duplication 23825009

Variation tolerance for ZNF609 Gene

Residual Variation Intolerance Score: 1.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF609 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF609

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF609 Gene

Disorders for ZNF609 Gene

Additional Disease Information for ZNF609

No disorders were found for ZNF609 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF609 Gene

Publications for ZNF609 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  2. Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. (PMID: 28344082) Legnini I … Bozzoni I (Molecular cell 2017) 3 4 58
  3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ZNF609 Gene

Sources for ZNF609 Gene

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