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Aliases for ZNF608 Gene

Aliases for ZNF608 Gene

  • Zinc Finger Protein 608 2 3 5
  • Renal Carcinoma Antigen NY-REN-36 3 4
  • NY-REN-36 3
  • KIAA1281 4

External Ids for ZNF608 Gene

Previous GeneCards Identifiers for ZNF608 Gene

  • GC05M124049
  • GC05M124000
  • GC05M123966
  • GC05M119162

Summaries for ZNF608 Gene

GeneCards Summary for ZNF608 Gene

ZNF608 (Zinc Finger Protein 608) is a Protein Coding gene. An important paralog of this gene is ZNF609.

UniProtKB/Swiss-Prot for ZNF608 Gene

  • Transcription factor, which represses ZNF609 transcription.

Additional gene information for ZNF608 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF608 Gene

Genomics for ZNF608 Gene

GeneHancer (GH) Regulatory Elements for ZNF608 Gene

Promoters and enhancers for ZNF608 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I124734 Promoter/Enhancer 3.1 UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.8 +5.7 5693 18.1 PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF213 FOS ZNF608 GC05P124742 ENSG00000251456 GC05P124737
GH05I124627 Enhancer 1.5 Ensembl ENCODE dbSUPER 10.2 +119.1 119077 3.9 PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF302 FOS SP3 ZNF608 GC05P124616 ENSG00000249112
GH05I124658 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.8 +87.3 87333 7 PKNOX1 FOXA2 MLX ARNT SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF213 ENSG00000251456 ZNF608 GC05P124616 ENSG00000249112
GH05I124789 Enhancer 1.1 Ensembl ENCODE 11.7 -42.7 -42709 3.5 PKNOX1 ARNT FEZF1 ZNF2 ZNF213 ATF7 KLF13 REST TSHZ1 ZNF518A ZNF608 ENSG00000251456 LOC105379156
GH05I124920 Enhancer 1 Ensembl ENCODE 10.7 -173.2 -173155 3.2 PKNOX1 SMAD1 BMI1 FEZF1 BATF ZNF213 ATF7 ETV6 IKZF2 RUNX3 ZNF608 ENSG00000251456 ENSG00000249423 PIR49961
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF608 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF608 gene promoter:

Genomic Locations for ZNF608 Gene

Genomic Locations for ZNF608 Gene
111,912 bases
Minus strand

Genomic View for ZNF608 Gene

Genes around ZNF608 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF608 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF608 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF608 Gene

Proteins for ZNF608 Gene

  • Protein details for ZNF608 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 608
    Protein Accession:
    Secondary Accessions:
    • A7E2W9
    • Q3SYM6
    • Q68D12
    • Q8IY05
    • Q9Y5A1

    Protein attributes for ZNF608 Gene

    1512 amino acids
    Molecular mass:
    162208 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA86595.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF608 Gene


neXtProt entry for ZNF608 Gene

Post-translational modifications for ZNF608 Gene

  • Ubiquitination at isoforms=21250
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF608 Gene

Domains & Families for ZNF608 Gene

Gene Families for ZNF608 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF608 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF608: view

No data available for UniProtKB/Swiss-Prot for ZNF608 Gene

Function for ZNF608 Gene

Molecular function for ZNF608 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor, which represses ZNF609 transcription.

Phenotypes From GWAS Catalog for ZNF608 Gene

Gene Ontology (GO) - Molecular Function for ZNF608 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF608: view
genes like me logo Genes that share phenotypes with ZNF608: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF608 Gene

Localization for ZNF608 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF608 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNF608 Gene

Pathways & Interactions for ZNF608 Gene

SuperPathways for ZNF608 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF608 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF608: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF608 Gene

Drugs & Compounds for ZNF608 Gene

No Compound Related Data Available

Transcripts for ZNF608 Gene

Unigene Clusters for ZNF608 Gene

Zinc finger protein 608:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF608 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP3: - -
SP4: - - - - - - -

Relevant External Links for ZNF608 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF608 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF608 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF608 Gene

This gene is overexpressed in Breast (24.0), Blymphocyte (18.8), Monocytes (8.1), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF608 Gene

Protein tissue co-expression partners for ZNF608 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF608 Gene:


SOURCE GeneReport for Unigene cluster for ZNF608 Gene:


Evidence on tissue expression from TISSUES for ZNF608 Gene

  • Liver(4.2)
  • Skin(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF608: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF608 Gene

Orthologs for ZNF608 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF608 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF608 33 34
  • 99.65 (n)
(Bos Taurus)
Mammalia ZNF608 33 34
  • 92.18 (n)
(Canis familiaris)
Mammalia ZNF608 33 34
  • 90.12 (n)
(Mus musculus)
Mammalia Zfp608 33 16 34
  • 89.85 (n)
(Rattus norvegicus)
Mammalia Zfp608 33
  • 89.44 (n)
(Ornithorhynchus anatinus)
Mammalia ZNF608 34
  • 87 (a)
(Monodelphis domestica)
Mammalia ZNF608 34
  • 86 (a)
(Gallus gallus)
Aves ZNF608 33 34
  • 82.97 (n)
(Anolis carolinensis)
Reptilia ZNF608 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf608 33
  • 72.51 (n)
Str.10279 33
(Danio rerio)
Actinopterygii LOC100329407 33
  • 54.2 (n)
ZNF608 34
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta sbb 34
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
Species where no ortholog for ZNF608 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF608 Gene

Gene Tree for ZNF608 (if available)
Gene Tree for ZNF608 (if available)

Paralogs for ZNF608 Gene

Paralogs for ZNF608 Gene

(2) SIMAP similar genes for ZNF608 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF608: view

Variants for ZNF608 Gene

Sequence variations from dbSNP and Humsavar for ZNF608 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000000396 -- 124,745,341(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000014558 -- 124,689,275(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000019869 -- 124,700,260(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000031178 -- 124,715,402(-) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000073354 -- 124,699,991(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF608 Gene

Variant ID Type Subtype PubMed ID
esv3309844 CNV mobile element insertion 20981092
esv3417666 CNV insertion 20981092
esv3436875 CNV insertion 20981092
esv3606634 CNV gain 21293372
esv3606635 CNV loss 21293372
nsv830473 CNV gain 17160897

Variation tolerance for ZNF608 Gene

Residual Variation Intolerance Score: 2.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF608 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF608 Gene

Disorders for ZNF608 Gene

Additional Disease Information for ZNF608

No disorders were found for ZNF608 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF608 Gene

Publications for ZNF608 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. (PMID: 10508479) Scanlan MJ … Old LJ (International journal of cancer 1999) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF608 Gene

Sources for ZNF608 Gene

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