Aliases for ZNF608 Gene

Aliases for ZNF608 Gene

  • Zinc Finger Protein 608 2 3 4 5
  • Renal Carcinoma Antigen NY-REN-36 3 4
  • NY-REN-36 2 3
  • KIAA1281 2 4
  • DKFZp434M098 2
  • ZNF608 5

External Ids for ZNF608 Gene

Previous GeneCards Identifiers for ZNF608 Gene

  • GC05M124049
  • GC05M124000
  • GC05M123966
  • GC05M119162

Summaries for ZNF608 Gene

GeneCards Summary for ZNF608 Gene

ZNF608 (Zinc Finger Protein 608) is a Protein Coding gene. Diseases associated with ZNF608 include Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant. An important paralog of this gene is ZNF609.

UniProtKB/Swiss-Prot Summary for ZNF608 Gene

Additional gene information for ZNF608 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF608 Gene

Genomics for ZNF608 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF608 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF608 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF608

Top Transcription factor binding sites by QIAGEN in the ZNF608 gene promoter:
  • AREB6
  • FOXO3
  • FOXO3a
  • FOXO3b
  • GR
  • GR-alpha
  • GR-beta
  • HSF1short
  • PPAR-alpha

Genomic Locations for ZNF608 Gene

Genomic Locations for ZNF608 Gene
chr5:124,636,913-124,748,824
(GRCh38/hg38)
Size:
111,912 bases
Orientation:
Minus strand
chr5:123,972,608-124,084,500
(GRCh37/hg19)
Size:
111,893 bases
Orientation:
Minus strand

Genomic View for ZNF608 Gene

Genes around ZNF608 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF608 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF608 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF608 Gene

Proteins for ZNF608 Gene

  • Protein details for ZNF608 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULD9-ZN608_HUMAN
    Recommended name:
    Zinc finger protein 608
    Protein Accession:
    Q9ULD9
    Secondary Accessions:
    • A7E2W9
    • Q3SYM6
    • Q68D12
    • Q8IY05
    • Q9Y5A1

    Protein attributes for ZNF608 Gene

    Size:
    1512 amino acids
    Molecular mass:
    162208 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86595.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF608 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF608 Gene

Post-translational modifications for ZNF608 Gene

  • Ubiquitination at Lys1250
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF608 Gene

Domains & Families for ZNF608 Gene

Gene Families for ZNF608 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF608 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF608 Gene

GenScript: Design optimal peptide antigens:
  • ZNF608 protein (A2RRB2_HUMAN)
  • cDNA FLJ31685 fis, clone NT2RI2005368, highly similar to Homo sapiens zinc finger protein 608 (ZNF608), mRNA (B3KPE6_HUMAN)
  • Zinc finger protein 608, isoform CRA_b (D3DSZ2_HUMAN)
  • Renal carcinoma antigen NY-REN-36 (ZN608_HUMAN)
genes like me logo Genes that share domains with ZNF608: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF608 Gene

Function for ZNF608 Gene

Molecular function for ZNF608 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor, which represses ZNF609 transcription.

Phenotypes From GWAS Catalog for ZNF608 Gene

Gene Ontology (GO) - Molecular Function for ZNF608 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF608: view
genes like me logo Genes that share phenotypes with ZNF608: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF608

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF608 Gene

Localization for ZNF608 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF608 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF608 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF608: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNF608 Gene

Pathways & Interactions for ZNF608 Gene

PathCards logo

SuperPathways for ZNF608 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF608 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA,ISS --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF608: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF608 Gene

Drugs & Compounds for ZNF608 Gene

No Compound Related Data Available

Transcripts for ZNF608 Gene

mRNA/cDNA for ZNF608 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF608

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF608 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2:
SP3: - -
SP4: - - - - - - -
SP5:
SP6:

Relevant External Links for ZNF608 Gene

GeneLoc Exon Structure for
ZNF608

Expression for ZNF608 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF608 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF608 Gene

This gene is overexpressed in Breast (24.0), Blymphocyte (18.8), Monocytes (8.1), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF608 Gene



Protein tissue co-expression partners for ZNF608 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF608

SOURCE GeneReport for Unigene cluster for ZNF608 Gene:

Hs.266616

Evidence on tissue expression from TISSUES for ZNF608 Gene

  • Skin(4.4)
  • Nervous system(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZNF608: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF608 Gene

Orthologs for ZNF608 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF608 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF608 30 31
  • 99.65 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF608 30 31
  • 92.18 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF608 30 31
  • 90.12 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp608 30 17 31
  • 89.85 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp608 30
  • 89.44 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF608 31
  • 87 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF608 31
  • 86 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF608 30 31
  • 82.97 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZNF608 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia znf608 30
  • 72.51 (n)
Str.10279 30
Zebrafish
(Danio rerio)
Actinopterygii LOC100329407 30
  • 54.2 (n)
ZNF608 31
  • 41 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta sbb 31
  • 14 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 55 (a)
OneToMany
Species where no ortholog for ZNF608 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF608 Gene

ENSEMBL:
Gene Tree for ZNF608 (if available)
TreeFam:
Gene Tree for ZNF608 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF608: view image

Paralogs for ZNF608 Gene

Paralogs for ZNF608 Gene

(2) SIMAP similar genes for ZNF608 Gene using alignment to 4 proteins:

  • ZN608_HUMAN
  • A2RRB2_HUMAN
  • B3KPE6_HUMAN
  • D3DSZ2_HUMAN
genes like me logo Genes that share paralogs with ZNF608: view

Variants for ZNF608 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF608 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
773323 Benign: not provided 124,639,221(-) G/A INTRON_VARIANT
rs6862252 - p.Thr721Asn

Additional dbSNP identifiers (rs#s) for ZNF608 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF608 Gene

Variant ID Type Subtype PubMed ID
esv3309844 CNV mobile element insertion 20981092
esv3417666 CNV insertion 20981092
esv3436875 CNV insertion 20981092
esv3606634 CNV gain 21293372
esv3606635 CNV loss 21293372
nsv830473 CNV gain 17160897

Variation tolerance for ZNF608 Gene

Residual Variation Intolerance Score: 2.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF608 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF608

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF608 Gene

Disorders for ZNF608 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF608 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF608

genes like me logo Genes that share disorders with ZNF608: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF608 Gene

Publications for ZNF608 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  2. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. (PMID: 10508479) Scanlan MJ … Old LJ (International journal of cancer 1999) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3

Products for ZNF608 Gene

Sources for ZNF608 Gene