Aliases for ZNF606 Gene
External Ids for ZNF606 Gene
Previous HGNC Symbols for ZNF606 Gene
Previous GeneCards Identifiers for ZNF606 Gene
This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) domain at its N-terminus, followed by contiguous C2H2 zinc finger motifs. The encoded protein is a nuclear protein that can act as a transcriptional repressor of growth factor-mediated signaling pathways in a reporter gene assay. This protein has been shown to interact with the SRY-box 9 gene product, and suppresses its transcriptional activity by inhibiting its DNA binding activity. Reduced expression of this gene promotes chondrocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
GeneCards Summary for ZNF606 Gene
ZNF606 (Zinc Finger Protein 606) is a Protein Coding gene. Diseases associated with ZNF606 include Adult Hepatocellular Carcinoma and Cecum Adenocarcinoma. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF624.
UniProtKB/Swiss-Prot Summary for ZNF606 Gene
May act as a transcriptional repressor.