This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) domain at its N-terminus, followed by contiguous C2H2 zinc finger motifs. The encoded protein is a nuclear protein that can act as a transcriptional repressor of growth factor-mediated signaling pathways in a reporter gene assay. This protein has been shown to interact with the SRY-box 9 gene pro... See more...

Aliases for ZNF606 Gene

Aliases for ZNF606 Gene

  • Zinc Finger Protein 606 2 3 4 5
  • Zinc Finger Protein 328 3 4
  • KIAA1852 2 4
  • ZNF328 3 4
  • FLJ14260 2
  • ZNF606 5

External Ids for ZNF606 Gene

Previous HGNC Symbols for ZNF606 Gene

  • ZNF328

Previous GeneCards Identifiers for ZNF606 Gene

  • GC19M063076
  • GC19M063181
  • GC19M058488
  • GC19M054799

Summaries for ZNF606 Gene

Entrez Gene Summary for ZNF606 Gene

  • This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) domain at its N-terminus, followed by contiguous C2H2 zinc finger motifs. The encoded protein is a nuclear protein that can act as a transcriptional repressor of growth factor-mediated signaling pathways in a reporter gene assay. This protein has been shown to interact with the SRY-box 9 gene product, and suppresses its transcriptional activity by inhibiting its DNA binding activity. Reduced expression of this gene promotes chondrocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

GeneCards Summary for ZNF606 Gene

ZNF606 (Zinc Finger Protein 606) is a Protein Coding gene. Diseases associated with ZNF606 include Adult Hepatocellular Carcinoma and Cecum Adenocarcinoma. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF624.

UniProtKB/Swiss-Prot Summary for ZNF606 Gene

Additional gene information for ZNF606 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF606 Gene

Genomics for ZNF606 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF606 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF606 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF606

Top Transcription factor binding sites by QIAGEN in the ZNF606 gene promoter:
  • AP-1
  • AP-4
  • ATF-2
  • c-Jun
  • GR-beta
  • STAT3

Genomic Locations for ZNF606 Gene

Genomic Locations for ZNF606 Gene
chr19:57,977,048-58,003,349
(GRCh38/hg38)
Size:
26,302 bases
Orientation:
Minus strand
chr19:58,488,421-58,514,717
(GRCh37/hg19)
Size:
26,297 bases
Orientation:
Minus strand

Genomic View for ZNF606 Gene

Genes around ZNF606 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF606 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF606 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF606 Gene

Proteins for ZNF606 Gene

  • Protein details for ZNF606 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXB4-ZN606_HUMAN
    Recommended name:
    Zinc finger protein 606
    Protein Accession:
    Q8WXB4
    Secondary Accessions:
    • A8KAN2
    • Q8NE04
    • Q96JH5

    Protein attributes for ZNF606 Gene

    Size:
    792 amino acids
    Molecular mass:
    91812 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47481.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZNF606 Gene

Post-translational modifications for ZNF606 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF606 Gene

Domains & Families for ZNF606 Gene

Gene Families for ZNF606 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF606 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF606 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 328 (ZN606_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WXB4

UniProtKB/Swiss-Prot:

ZN606_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF606: view

Function for ZNF606 Gene

Molecular function for ZNF606 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF606 Gene

Gene Ontology (GO) - Molecular Function for ZNF606 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF606: view
genes like me logo Genes that share phenotypes with ZNF606: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF606

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF606 Gene

Localization for ZNF606 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF606 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF606 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF606 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF606: view

Pathways & Interactions for ZNF606 Gene

genes like me logo Genes that share pathways with ZNF606: view

Pathways by source for ZNF606 Gene

2 Reactome pathways for ZNF606 Gene
1 KEGG pathway for ZNF606 Gene

Gene Ontology (GO) - Biological Process for ZNF606 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF606: view

No data available for SIGNOR curated interactions for ZNF606 Gene

Drugs & Compounds for ZNF606 Gene

No Compound Related Data Available

Transcripts for ZNF606 Gene

mRNA/cDNA for ZNF606 Gene

5 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF606

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF606 Gene

No ASD Table

Relevant External Links for ZNF606 Gene

GeneLoc Exon Structure for
ZNF606

Expression for ZNF606 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF606 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF606

SOURCE GeneReport for Unigene cluster for ZNF606 Gene:

Hs.654967

mRNA Expression by UniProt/SwissProt for ZNF606 Gene:

Q8WXB4-ZN606_HUMAN
Tissue specificity: Widely expressed in adult and fetal tissues.

Evidence on tissue expression from TISSUES for ZNF606 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZNF606: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF606 Gene

Orthologs for ZNF606 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF606 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF606 30 31
  • 99.62 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF606 30 31
  • 92.24 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF606 31
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp606 30 17 31
  • 89.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp606 30
  • 88.61 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 57 (a)
OneToMany
Species where no ortholog for ZNF606 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF606 Gene

ENSEMBL:
Gene Tree for ZNF606 (if available)
TreeFam:
Gene Tree for ZNF606 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF606: view image

Paralogs for ZNF606 Gene

Paralogs for ZNF606 Gene

(538) SIMAP similar genes for ZNF606 Gene using alignment to 8 proteins:

  • ZN606_HUMAN
  • F5H208_HUMAN
  • F8VVX5_HUMAN
  • F8VZC9_HUMAN
  • F8VZG6_HUMAN
  • F8W1C8_HUMAN
  • F8W1H2_HUMAN
  • L8ECK5_HUMAN
genes like me logo Genes that share paralogs with ZNF606: view

Variants for ZNF606 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF606 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
736584 Likely Benign: not provided 57,978,907(-) C/T SYNONYMOUS_VARIANT
781900 Benign: not provided 57,979,671(-) T/G SYNONYMOUS_VARIANT
785645 Benign: not provided 57,979,327(-) A/T SYNONYMOUS_VARIANT
785646 Benign: not provided 57,980,134(-) T/C SYNONYMOUS_VARIANT
rs386352385 Uncertain Significance: not provided 57,978,581(-) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF606 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF606 Gene

Variant ID Type Subtype PubMed ID
esv3644917 CNV loss 21293372
esv3644918 CNV gain 21293372
esv3644919 CNV loss 21293372
esv3893258 CNV gain 25118596
nsv1066059 CNV gain 25217958
nsv1123282 CNV deletion 24896259
nsv516650 CNV loss 19592680
nsv833885 CNV loss 17160897

Variation tolerance for ZNF606 Gene

Residual Variation Intolerance Score: 19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.89; 74.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF606 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF606

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF606 Gene

Disorders for ZNF606 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF606 Gene - From: DISEASES

Disorder Aliases PubMed IDs
adult hepatocellular carcinoma
  • adult hepatoma
cecum adenocarcinoma
  • cecal adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF606: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF606 Gene

Publications for ZNF606 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4
  2. ZNF328, a novel human zinc-finger protein, suppresses transcriptional activities of SRE and AP-1. (PMID: 15964554) Ou Y … Liu M (Biochemical and biophysical research communications 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Association of expression of ZNF606 gene from monocytes with the risk of coronary artery disease. (PMID: 30130524) Guo J … Chen A (Clinical biochemistry 2018) 3

Products for ZNF606 Gene

Sources for ZNF606 Gene