Aliases for ZNF605 Gene

Aliases for ZNF605 Gene

  • Zinc Finger Protein 605 2 3 4 5
  • EC 51
  • EC 51
  • ZNF605 5

External Ids for ZNF605 Gene

Previous GeneCards Identifiers for ZNF605 Gene

  • GC12M131737
  • GC12M132108
  • GC12M132008
  • GC00U928747
  • GC12M133499
  • GC12M130274

Summaries for ZNF605 Gene

GeneCards Summary for ZNF605 Gene

ZNF605 (Zinc Finger Protein 605) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF268.

UniProtKB/Swiss-Prot Summary for ZNF605 Gene

Additional gene information for ZNF605 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF605 Gene

Genomics for ZNF605 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF605 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF605 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF605

Genomic Locations for ZNF605 Gene

Genomic Locations for ZNF605 Gene
38,001 bases
Minus strand
34,874 bases
Minus strand

Genomic View for ZNF605 Gene

Genes around ZNF605 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF605 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF605 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF605 Gene

Proteins for ZNF605 Gene

  • Protein details for ZNF605 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 605
    Protein Accession:
    Secondary Accessions:
    • B3KVG4
    • D3DXJ0
    • Q86T91

    Protein attributes for ZNF605 Gene

    641 amino acids
    Molecular mass:
    74376 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF605 Gene


neXtProt entry for ZNF605 Gene

Selected DME Specific Peptides for ZNF605 Gene


Post-translational modifications for ZNF605 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF605 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ZNF605 Gene

Gene Families for ZNF605 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF605 Gene

  • C2H2-type zinc finger signature
  • KRAB box

Suggested Antigen Peptide Sequences for ZNF605 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ16520 fis, clone NT2RI3007878, highly similar to Zinc finger protein 605 (B3KVG4_HUMAN)
  • ZNF605 protein (Q8WW51_HUMAN)
  • Zinc finger protein 605 (ZN605_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF605: view

Function for ZNF605 Gene

Molecular function for ZNF605 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Enzyme Numbers (IUBMB) for ZNF605 Gene

Phenotypes From GWAS Catalog for ZNF605 Gene

Gene Ontology (GO) - Molecular Function for ZNF605 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF605: view
genes like me logo Genes that share phenotypes with ZNF605: view

Animal Model Products

CRISPR Products

miRNA for ZNF605 Gene

miRTarBase miRNAs that target ZNF605

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF605

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF605 Gene

Localization for ZNF605 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF605 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF605 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF605 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF605: view

Pathways & Interactions for ZNF605 Gene

genes like me logo Genes that share pathways with ZNF605: view

Pathways by source for ZNF605 Gene

2 Reactome pathways for ZNF605 Gene
1 KEGG pathway for ZNF605 Gene

Interacting Proteins for ZNF605 Gene

Gene Ontology (GO) - Biological Process for ZNF605 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF605: view

No data available for SIGNOR curated interactions for ZNF605 Gene

Drugs & Compounds for ZNF605 Gene

No Compound Related Data Available

Transcripts for ZNF605 Gene

mRNA/cDNA for ZNF605 Gene

7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF605

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF605 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP3: -

Relevant External Links for ZNF605 Gene

GeneLoc Exon Structure for

Expression for ZNF605 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF605 Gene

Protein differential expression in normal tissues from HIPED for ZNF605 Gene

This gene is overexpressed in Heart (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF605 Gene

Protein tissue co-expression partners for ZNF605 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF605

SOURCE GeneReport for Unigene cluster for ZNF605 Gene:


Evidence on tissue expression from TISSUES for ZNF605 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF605: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF605 Gene

Orthologs for ZNF605 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF605 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF605 30 31
  • 99.06 (n)
(Canis familiaris)
Mammalia ZNF605 30 31
  • 86.92 (n)
(Bos Taurus)
Mammalia ZNF605 30 31
  • 86.71 (n)
(Mus musculus)
Mammalia Zfp605 30 17 31
  • 76.05 (n)
(Rattus norvegicus)
Mammalia LOC100365779 30
  • 72.48 (n)
Species where no ortholog for ZNF605 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF605 Gene

Gene Tree for ZNF605 (if available)
Gene Tree for ZNF605 (if available)
Evolutionary constrained regions (ECRs) for ZNF605: view image

Paralogs for ZNF605 Gene

Paralogs for ZNF605 Gene

(445) SIMAP similar genes for ZNF605 Gene using alignment to 2 proteins:

  • ZN605_HUMAN
  • Q8WW51_HUMAN Pseudogenes for ZNF605 Gene

genes like me logo Genes that share paralogs with ZNF605: view

Variants for ZNF605 Gene

Additional dbSNP identifiers (rs#s) for ZNF605 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF605 Gene

Variant ID Type Subtype PubMed ID
dgv1589n100 CNV gain 25217958
dgv330e199 CNV deletion 23128226
dgv331e199 CNV deletion 23128226
dgv917n106 CNV deletion 24896259
dgv949e59 CNV duplication 20981092
esv1007810 CNV insertion 20482838
esv22416 CNV loss 19812545
esv2759923 CNV loss 17122850
esv3427404 CNV duplication 20981092
esv3631325 CNV loss 21293372
nsv1041440 CNV loss 25217958
nsv1070156 CNV deletion 25765185
nsv1071081 CNV deletion 25765185
nsv1126337 CNV deletion 24896259
nsv470335 CNV loss 18288195
nsv509495 CNV insertion 20534489
nsv513380 CNV insertion 21212237
nsv528637 CNV loss 19592680
nsv561135 CNV loss 21841781
nsv9046 CNV gain 18304495
nsv945 CNV insertion 18451855
nsv952514 CNV deletion 24416366

Variation tolerance for ZNF605 Gene

Gene Damage Index Score: 0.44; 9.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF605 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF605 Gene

Disorders for ZNF605 Gene

Additional Disease Information for ZNF605

No disorders were found for ZNF605 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF605 Gene

Publications for ZNF605 Gene

  1. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A … Wanker EE (Science signaling 2011) 3
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for ZNF605 Gene

Sources for ZNF605 Gene