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Aliases for ZNF600 Gene

Aliases for ZNF600 Gene

  • Zinc Finger Protein 600 2 3 3 5
  • Zinc Finger Protein KR-ZNF1 3
  • KR-ZNF1 3

External Ids for ZNF600 Gene

Previous GeneCards Identifiers for ZNF600 Gene

  • GC19M057959
  • GC19M057948
  • GC19M053267
  • GC19M049596

Summaries for ZNF600 Gene

GeneCards Summary for ZNF600 Gene

ZNF600 (Zinc Finger Protein 600) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF836.

UniProtKB/Swiss-Prot for ZNF600 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF600 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF600 Gene

Genomics for ZNF600 Gene

GeneHancer (GH) Regulatory Elements for ZNF600 Gene

Promoters and enhancers for ZNF600 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J052785 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 663.7 +47.0 47016 2 HDGF SMAD1 ARID4B SIN3A DMAP1 ZNF48 ZNF280A SLC30A9 POLR2B ZNF143 ZNF600 ZNF611 ZNF28 GC19M052801 LOC105372451
GH19J052832 Enhancer 0.2 ENCODE 650.7 +0.2 213 1.3 ZNF600 ZNF468 ZNF28 LOC100420798
GH19J052137 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 43.6 +694.0 693996 3.3 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF616 ZNF137P ZNF160 ZNF808 ENSG00000268970 ZNF600 ZNF350 ZNF816 ZNF836 ZNF577
GH19J053466 Promoter/Enhancer 1.4 Ensembl ENCODE 33.2 -634.3 -634263 1.8 PKNOX1 ATF1 ARID4B DMAP1 SLC30A9 POLR2B E2F8 ATF7 SP3 SP5 ZNF813 CNOT3 ZNF701 ZNF600 LENG8 ZNF845 ZNF808 ENSG00000269001 ENSG00000268970 ZNF160
GH19J052820 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 25.6 +12.1 12079 1.5 HDGF HDAC1 SIN3A NFXL1 ZNF335 ZNF366 ZNF207 ZNF143 IKZF2 ZNF362 ZNF28 ZNF600 ZNF701 ZNF845 ZNF808 ENSG00000269001 ZNF350 ZNF160 ENSG00000268970 ZNF836
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF600 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF600 gene promoter:
  • Nkx2-5
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4

Genomic Locations for ZNF600 Gene

Genomic Locations for ZNF600 Gene
chr19:52,764,195-52,833,628
(GRCh38/hg38)
Size:
69,434 bases
Orientation:
Minus strand
chr19:53,267,448-53,290,044
(GRCh37/hg19)
Size:
22,597 bases
Orientation:
Minus strand

Genomic View for ZNF600 Gene

Genes around ZNF600 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF600 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF600 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF600 Gene

Proteins for ZNF600 Gene

  • Protein details for ZNF600 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNG1-ZN600_HUMAN
    Recommended name:
    Zinc finger protein 600
    Protein Accession:
    Q6ZNG1
    Secondary Accessions:
    • Q6MZR0

    Protein attributes for ZNF600 Gene

    Size:
    722 amino acids
    Molecular mass:
    83124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF600 Gene

Post-translational modifications for ZNF600 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF600 Gene

No data available for DME Specific Peptides for ZNF600 Gene

Domains & Families for ZNF600 Gene

Gene Families for ZNF600 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF600 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF600 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNG1

UniProtKB/Swiss-Prot:

ZN600_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF600: view

Function for ZNF600 Gene

Molecular function for ZNF600 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF600 Gene

Gene Ontology (GO) - Molecular Function for ZNF600 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF600: view
genes like me logo Genes that share phenotypes with ZNF600: view

Animal Model Products

miRNA for ZNF600 Gene

miRTarBase miRNAs that target ZNF600

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF600 Gene

Localization for ZNF600 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF600 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF600 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF600 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF600: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF600 Gene

Pathways & Interactions for ZNF600 Gene

SuperPathways for ZNF600 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF600: view

Pathways by source for ZNF600 Gene

2 Reactome pathways for ZNF600 Gene

Gene Ontology (GO) - Biological Process for ZNF600 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF600: view

No data available for SIGNOR curated interactions for ZNF600 Gene

Drugs & Compounds for ZNF600 Gene

No Compound Related Data Available

Transcripts for ZNF600 Gene

Unigene Clusters for ZNF600 Gene

Zinc finger protein 600:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF600 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1: - - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for ZNF600 Gene

GeneLoc Exon Structure for
ZNF600
ECgene alternative splicing isoforms for
ZNF600

Expression for ZNF600 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF600 Gene

Protein differential expression in normal tissues from HIPED for ZNF600 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF600 Gene



Protein tissue co-expression partners for ZNF600 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF600 Gene:

ZNF600

SOURCE GeneReport for Unigene cluster for ZNF600 Gene:

Hs.696848

Evidence on tissue expression from TISSUES for ZNF600 Gene

  • Nervous system(4.1)
  • Intestine(3.3)
  • Pancreas(3.1)
  • Skin(3.1)
genes like me logo Genes that share expression patterns with ZNF600: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF600 Gene

Orthologs for ZNF600 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF600 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF600 34 33
  • 96.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 43 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 43 (a)
ManyToMany
Species where no ortholog for ZNF600 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF600 Gene

ENSEMBL:
Gene Tree for ZNF600 (if available)
TreeFam:
Gene Tree for ZNF600 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF600: view image

Paralogs for ZNF600 Gene

Paralogs for ZNF600 Gene

(621) SIMAP similar genes for ZNF600 Gene using alignment to 2 proteins:

  • ZN600_HUMAN
  • Q13580_HUMAN
genes like me logo Genes that share paralogs with ZNF600: view

Variants for ZNF600 Gene

Sequence variations from dbSNP and Humsavar for ZNF600 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000188220 -- 52,774,441(-) C/A/T intron_variant
rs1000239116 -- 52,768,404(-) C/T intron_variant
rs1000322919 -- 52,764,699(-) A/G downstream_transcript_variant
rs1000495693 -- 52,769,558(-) A/G intron_variant
rs1000551525 -- 52,783,179(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF600 Gene

Variant ID Type Subtype PubMed ID
dgv3629n100 CNV loss 25217958
dgv6527n54 CNV gain 21841781
esv2664794 CNV deletion 23128226
esv2671531 CNV deletion 23128226
esv2718786 CNV deletion 23290073
esv2718787 CNV deletion 23290073
esv2718796 CNV deletion 23290073
esv2718798 CNV deletion 23290073
esv3644719 CNV gain 21293372
esv3644720 CNV loss 21293372
esv3644721 CNV loss 21293372
esv3893231 CNV loss 25118596
esv3893234 CNV gain 25118596
nsv1055617 CNV loss 25217958
nsv1057118 CNV gain 25217958
nsv1062976 CNV gain 25217958
nsv1066762 CNV gain 25217958
nsv1067557 CNV gain 25217958
nsv1078889 OTHER inversion 25765185
nsv1140479 CNV deletion 24896259
nsv1146332 OTHER inversion 26484159
nsv458745 CNV gain 19166990
nsv458746 CNV gain 19166990
nsv509752 CNV insertion 20534489
nsv527597 CNV loss 19592680
nsv580030 CNV gain 21841781
nsv580031 CNV gain 21841781
nsv833875 CNV loss 17160897
nsv961240 CNV duplication 23825009

Variation tolerance for ZNF600 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF600 Gene

Human Gene Mutation Database (HGMD)
ZNF600
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF600

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF600 Gene

Disorders for ZNF600 Gene

Additional Disease Information for ZNF600

No disorders were found for ZNF600 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF600 Gene

Publications for ZNF600 Gene

  1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A … EUROSPAN consortium (PLoS genetics 2012) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs. (PMID: 12576331) Yang XO … Willerford DM (Blood 2003) 2 3 58
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S … Ideker T (Nature methods 2010) 3 58
  5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V … Han DK (Science signaling 2009) 4 58

Products for ZNF600 Gene

Sources for ZNF600 Gene

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