Aliases for ZNF600 Gene

Aliases for ZNF600 Gene

  • Zinc Finger Protein 600 2 3 4 5
  • KR-ZNF1 2 3
  • Zinc Finger Protein KR-ZNF1 3
  • DKFZp686F06123 2
  • ZNF600 5

External Ids for ZNF600 Gene

Previous GeneCards Identifiers for ZNF600 Gene

  • GC19M057959
  • GC19M057948
  • GC19M053267
  • GC19M049596
  • GC19M052764

Summaries for ZNF600 Gene

GeneCards Summary for ZNF600 Gene

ZNF600 (Zinc Finger Protein 600) is a Protein Coding gene. Diseases associated with ZNF600 include Good Syndrome. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF611.

UniProtKB/Swiss-Prot Summary for ZNF600 Gene

Additional gene information for ZNF600 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF600 Gene

Genomics for ZNF600 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF600 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF600 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF600

Top Transcription factor binding sites by QIAGEN in the ZNF600 gene promoter:
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Nkx2-5

Genomic Locations for ZNF600 Gene

Genomic Locations for ZNF600 Gene
chr19:52,749,942-52,786,825
(GRCh38/hg38)
Size:
36,884 bases
Orientation:
Minus strand
chr19:53,267,448-53,290,044
(GRCh37/hg19)
Size:
22,597 bases
Orientation:
Minus strand

Genomic View for ZNF600 Gene

Genes around ZNF600 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF600 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF600 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF600 Gene

Proteins for ZNF600 Gene

  • Protein details for ZNF600 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNG1-ZN600_HUMAN
    Recommended name:
    Zinc finger protein 600
    Protein Accession:
    Q6ZNG1
    Secondary Accessions:
    • Q6MZR0

    Protein attributes for ZNF600 Gene

    Size:
    722 amino acids
    Molecular mass:
    83124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF600 Gene

Post-translational modifications for ZNF600 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF600 Gene

Domains & Families for ZNF600 Gene

Gene Families for ZNF600 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF600 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF600 Gene

GenScript: Design optimal peptide antigens:
  • KR-ZNF1 (Q13580_HUMAN)
  • Zinc finger protein 600 (ZN600_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZNG1

UniProtKB/Swiss-Prot:

ZN600_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF600: view

Function for ZNF600 Gene

Molecular function for ZNF600 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF600 Gene

Gene Ontology (GO) - Molecular Function for ZNF600 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA --
GO:0003700 DNA-binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF600: view
genes like me logo Genes that share phenotypes with ZNF600: view

Animal Model Products

CRISPR Products

miRNA for ZNF600 Gene

miRTarBase miRNAs that target ZNF600

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF600

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF600 Gene

Localization for ZNF600 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF600 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF600 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF600 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF600: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF600 Gene

Pathways & Interactions for ZNF600 Gene

genes like me logo Genes that share pathways with ZNF600: view

Pathways by source for ZNF600 Gene

2 Reactome pathways for ZNF600 Gene
1 KEGG pathway for ZNF600 Gene

Gene Ontology (GO) - Biological Process for ZNF600 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF600: view

No data available for SIGNOR curated interactions for ZNF600 Gene

Drugs & Compounds for ZNF600 Gene

No Compound Related Data Available

Transcripts for ZNF600 Gene

mRNA/cDNA for ZNF600 Gene

3 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF600

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF600 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1: - - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for ZNF600 Gene

GeneLoc Exon Structure for
ZNF600

Expression for ZNF600 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF600 Gene

Protein differential expression in normal tissues from HIPED for ZNF600 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF600 Gene



Protein tissue co-expression partners for ZNF600 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF600

SOURCE GeneReport for Unigene cluster for ZNF600 Gene:

Hs.696848

Evidence on tissue expression from TISSUES for ZNF600 Gene

  • Nervous system(4.1)
  • Intestine(3.3)
  • Skin(3.1)
  • Pancreas(3.1)
genes like me logo Genes that share expression patterns with ZNF600: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF600 Gene

Orthologs for ZNF600 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF600 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF600 30 31
  • 96.08 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 43 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 43 (a)
ManyToMany
Species where no ortholog for ZNF600 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF600 Gene

ENSEMBL:
Gene Tree for ZNF600 (if available)
TreeFam:
Gene Tree for ZNF600 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF600: view image

Paralogs for ZNF600 Gene

Paralogs for ZNF600 Gene

(621) SIMAP similar genes for ZNF600 Gene using alignment to 2 proteins:

  • ZN600_HUMAN
  • Q13580_HUMAN
genes like me logo Genes that share paralogs with ZNF600: view

Variants for ZNF600 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF600 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
730384 Benign: not provided 52,767,564(-) T/A MISSENSE_VARIANT
731419 Likely Benign: not provided 52,765,820(-) CTT/C FRAMESHIFT_VARIANT
731531 Likely Benign: not provided 52,767,054(-) T/C SYNONYMOUS_VARIANT
734866 Benign: not provided 52,766,680(-) T/C MISSENSE_VARIANT
734867 Benign: not provided 52,767,004(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF600 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF600 Gene

Variant ID Type Subtype PubMed ID
dgv3629n100 CNV loss 25217958
dgv6527n54 CNV gain 21841781
esv2664794 CNV deletion 23128226
esv2671531 CNV deletion 23128226
esv2718786 CNV deletion 23290073
esv2718787 CNV deletion 23290073
esv2718796 CNV deletion 23290073
esv2718798 CNV deletion 23290073
esv3644719 CNV gain 21293372
esv3644720 CNV loss 21293372
esv3644721 CNV loss 21293372
esv3893231 CNV loss 25118596
esv3893234 CNV gain 25118596
nsv1055617 CNV loss 25217958
nsv1057118 CNV gain 25217958
nsv1062976 CNV gain 25217958
nsv1066762 CNV gain 25217958
nsv1067557 CNV gain 25217958
nsv1078889 OTHER inversion 25765185
nsv1140479 CNV deletion 24896259
nsv1146332 OTHER inversion 26484159
nsv458745 CNV gain 19166990
nsv458746 CNV gain 19166990
nsv509752 CNV insertion 20534489
nsv527597 CNV loss 19592680
nsv580030 CNV gain 21841781
nsv580031 CNV gain 21841781
nsv833875 CNV loss 17160897
nsv961240 CNV duplication 23825009

Variation tolerance for ZNF600 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF600 Gene

Human Gene Mutation Database (HGMD)
ZNF600
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF600

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF600 Gene

Disorders for ZNF600 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF600 Gene - From: DISEASES

Disorder Aliases PubMed IDs
good syndrome
  • thymoma with hypogammaglobulinemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF600

genes like me logo Genes that share disorders with ZNF600: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF600 Gene

Publications for ZNF600 Gene

  1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A … EUROSPAN consortium (PLoS genetics 2012) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs. (PMID: 12576331) Yang XO … Willerford DM (Blood 2003) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF600 Gene

Sources for ZNF600 Gene