Aliases for ZNF599 Gene

Aliases for ZNF599 Gene

  • Zinc Finger Protein 599 2 3 4 5

External Ids for ZNF599 Gene

Previous GeneCards Identifiers for ZNF599 Gene

  • GC19M039940
  • GC19M035248
  • GC19M031755

Summaries for ZNF599 Gene

GeneCards Summary for ZNF599 Gene

ZNF599 (Zinc Finger Protein 599) is a Protein Coding gene. Diseases associated with ZNF599 include Chromosome 19Q13.11 Deletion Syndrome and Brugada Syndrome 5. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF805.

UniProtKB/Swiss-Prot Summary for ZNF599 Gene

Additional gene information for ZNF599 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF599 Gene

Genomics for ZNF599 Gene

GeneHancer (GH) Regulatory Elements for ZNF599 Gene

Promoters and enhancers for ZNF599 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF599 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF599

Top Transcription factor binding sites by QIAGEN in the ZNF599 gene promoter:
  • c-Rel
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • POU2F1
  • POU2F1a
  • STAT3

Genomic Locations for ZNF599 Gene

Genomic Locations for ZNF599 Gene
chr19:34,758,073-34,773,229
(GRCh38/hg38)
Size:
15,157 bases
Orientation:
Minus strand
chr19:35,248,979-35,264,134
(GRCh37/hg19)
Size:
15,156 bases
Orientation:
Minus strand

Genomic View for ZNF599 Gene

Genes around ZNF599 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF599 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF599 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF599 Gene

Proteins for ZNF599 Gene

  • Protein details for ZNF599 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NL3-ZN599_HUMAN
    Recommended name:
    Zinc finger protein 599
    Protein Accession:
    Q96NL3
    Secondary Accessions:
    • Q569K0
    • Q5PRG1

    Protein attributes for ZNF599 Gene

    Size:
    588 amino acids
    Molecular mass:
    67492 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH44615.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF599 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF599 Gene

Post-translational modifications for ZNF599 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF599 Gene

No data available for DME Specific Peptides for ZNF599 Gene

Domains & Families for ZNF599 Gene

Gene Families for ZNF599 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF599 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF599 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 599 (ZN599_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96NL3

UniProtKB/Swiss-Prot:

ZN599_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF599: view

Function for ZNF599 Gene

Molecular function for ZNF599 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF599 Gene

Gene Ontology (GO) - Molecular Function for ZNF599 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF599: view
genes like me logo Genes that share phenotypes with ZNF599: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF599 Gene

Localization for ZNF599 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF599 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF599 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF599 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF599: view

Pathways & Interactions for ZNF599 Gene

genes like me logo Genes that share pathways with ZNF599: view

Pathways by source for ZNF599 Gene

2 Reactome pathways for ZNF599 Gene
1 KEGG pathway for ZNF599 Gene

Interacting Proteins for ZNF599 Gene

;

Gene Ontology (GO) - Biological Process for ZNF599 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF599: view

No data available for SIGNOR curated interactions for ZNF599 Gene

Drugs & Compounds for ZNF599 Gene

No Compound Related Data Available

Transcripts for ZNF599 Gene

mRNA/cDNA for ZNF599 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF599 Gene

No ASD Table

Relevant External Links for ZNF599 Gene

GeneLoc Exon Structure for
ZNF599

Expression for ZNF599 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF599 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF599 Gene



Protein tissue co-expression partners for ZNF599 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF599

SOURCE GeneReport for Unigene cluster for ZNF599 Gene:

Hs.590961

Evidence on tissue expression from TISSUES for ZNF599 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF599: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF599 Gene

Orthologs for ZNF599 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF599 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF599 31 30
  • 98.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF599 31 30
  • 88.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF599 31 30
  • 86.96 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 38 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-7j22.3 31
  • 52 (a)
ManyToMany
CU138542.3 31
  • 43 (a)
ManyToMany
Species where no ortholog for ZNF599 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF599 Gene

ENSEMBL:
Gene Tree for ZNF599 (if available)
TreeFam:
Gene Tree for ZNF599 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF599: view image

Paralogs for ZNF599 Gene

(459) SIMAP similar genes for ZNF599 Gene using alignment to 2 proteins:

  • ZN599_HUMAN
  • K7EJP3_HUMAN
genes like me logo Genes that share paralogs with ZNF599: view

Variants for ZNF599 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF599 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs146342141 - p.Leu178Phe

Additional dbSNP identifiers (rs#s) for ZNF599 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF599 Gene

Variant ID Type Subtype PubMed ID
esv2758756 CNV gain 17122850

Variation tolerance for ZNF599 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF599 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF599

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF599 Gene

Disorders for ZNF599 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF599 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 19q13.11 deletion syndrome
  • 19q13.11 microdeletion syndrome
brugada syndrome 5
  • brgda5
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF599

genes like me logo Genes that share disorders with ZNF599: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF599 Gene

Publications for ZNF599 Gene

No publications were found for ZNF599 Gene.

Products for ZNF599 Gene

Sources for ZNF599 Gene