This gene encodes a protein with multiple zinc finger domains. Loss of the related gene in rodents results in defects in neural development and embryonic lethality in mutant homozygotes. This gene is adjacent to a differentially methylated region (DMR) and is imprinted and maternally expressed. [provided by RefSeq, Nov 2015] See more...

Aliases for ZNF597 Gene

Aliases for ZNF597 Gene

  • Zinc Finger Protein 597 2 3 4 5
  • HIT-4 2 3
  • FLJ33071 2
  • ZNF597 5

External Ids for ZNF597 Gene

Previous GeneCards Identifiers for ZNF597 Gene

  • GC16M003487
  • GC16M003426
  • GC16M003488
  • GC16M003467
  • GC16M003472
  • GC16M003502
  • GC16M003505
  • GC16M003504
  • GC16M003509
  • GC16M003475
  • GC16M003479
  • GC16M003481
  • GC16M003491
  • GC16M003494
  • GC16M003496
  • GC16M003498
  • GC16M003500

Summaries for ZNF597 Gene

Entrez Gene Summary for ZNF597 Gene

  • This gene encodes a protein with multiple zinc finger domains. Loss of the related gene in rodents results in defects in neural development and embryonic lethality in mutant homozygotes. This gene is adjacent to a differentially methylated region (DMR) and is imprinted and maternally expressed. [provided by RefSeq, Nov 2015]

GeneCards Summary for ZNF597 Gene

ZNF597 (Zinc Finger Protein 597) is a Protein Coding gene. Diseases associated with ZNF597 include Tinea Nigra and Inferior Myocardial Infarction. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF786.

UniProtKB/Swiss-Prot Summary for ZNF597 Gene

Additional gene information for ZNF597 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF597 Gene

Genomics for ZNF597 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF597 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF597 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF597

Top Transcription factor binding sites by QIAGEN in the ZNF597 gene promoter:
  • CBF(2)
  • FAC1
  • HNF-4alpha1
  • HNF-4alpha2
  • Ik-1
  • LCR-F1
  • NF-1
  • NF-Y
  • Nkx2-2
  • Zic1

Genomic Locations for ZNF597 Gene

Genomic Locations for ZNF597 Gene
chr16:3,432,414-3,443,504
(GRCh38/hg38)
Size:
11,091 bases
Orientation:
Minus strand
chr16:3,486,104-3,493,542
(GRCh37/hg19)
Size:
7,439 bases
Orientation:
Minus strand

Genomic View for ZNF597 Gene

Genes around ZNF597 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF597 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF597 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF597 Gene

Proteins for ZNF597 Gene

  • Protein details for ZNF597 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LX8-ZN597_HUMAN
    Recommended name:
    Zinc finger protein 597
    Protein Accession:
    Q96LX8

    Protein attributes for ZNF597 Gene

    Size:
    424 amino acids
    Molecular mass:
    48076 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF597 Gene

Post-translational modifications for ZNF597 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF597 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF597 Gene

Domains & Families for ZNF597 Gene

Gene Families for ZNF597 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF597 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF597 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 597 (ZN597_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96LX8

UniProtKB/Swiss-Prot:

ZN597_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF597: view

Function for ZNF597 Gene

Molecular function for ZNF597 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
UniProtKB/Swiss-Prot Induction:
Imprinted. Promoter methylation of the paternal allele may restrict expression to the maternal allele in leukocytes.

Phenotypes From GWAS Catalog for ZNF597 Gene

Gene Ontology (GO) - Molecular Function for ZNF597 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF597: view
genes like me logo Genes that share phenotypes with ZNF597: view

Animal Models for ZNF597 Gene

MGI Knock Outs for ZNF597:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF597

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF597 Gene

Localization for ZNF597 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF597 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF597 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF597 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF597: view

Pathways & Interactions for ZNF597 Gene

genes like me logo Genes that share pathways with ZNF597: view

Pathways by source for ZNF597 Gene

2 Reactome pathways for ZNF597 Gene
1 KEGG pathway for ZNF597 Gene

Gene Ontology (GO) - Biological Process for ZNF597 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010468 regulation of gene expression IBA 21873635
genes like me logo Genes that share ontologies with ZNF597: view

No data available for SIGNOR curated interactions for ZNF597 Gene

Drugs & Compounds for ZNF597 Gene

No Compound Related Data Available

Transcripts for ZNF597 Gene

mRNA/cDNA for ZNF597 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF597

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF597 Gene

No ASD Table

Relevant External Links for ZNF597 Gene

GeneLoc Exon Structure for
ZNF597

Expression for ZNF597 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF597 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF597 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF597

SOURCE GeneReport for Unigene cluster for ZNF597 Gene:

Hs.88630

Evidence on tissue expression from TISSUES for ZNF597 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF597: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF597 Gene

Orthologs for ZNF597 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF597 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF597 30 31
  • 98.82 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF597 30 31
  • 80.87 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp597 30 17 31
  • 76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp597 30
  • 74.82 (n)
Cow
(Bos Taurus)
Mammalia ZNF597 31
  • 57 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF597 31
  • 32 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CR352258.1 31
  • 30 (a)
OneToMany
Species where no ortholog for ZNF597 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF597 Gene

ENSEMBL:
Gene Tree for ZNF597 (if available)
TreeFam:
Gene Tree for ZNF597 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF597: view image

Paralogs for ZNF597 Gene

Paralogs for ZNF597 Gene

(231) SIMAP similar genes for ZNF597 Gene using alignment to 1 proteins:

  • ZN597_HUMAN
genes like me logo Genes that share paralogs with ZNF597: view

Variants for ZNF597 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF597 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
768744 Benign: not provided 3,436,736(-) G/A SYNONYMOUS_VARIANT
780017 Benign: not provided 3,436,577(-) G/A SYNONYMOUS_VARIANT
rs2270493 - p.Thr30Ser

Additional dbSNP identifiers (rs#s) for ZNF597 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF597 Gene

Variant ID Type Subtype PubMed ID
esv29492 CNV gain 19812545
esv3637667 CNV gain 21293372
nsv1051957 CNV loss 25217958

Variation tolerance for ZNF597 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF597 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF597

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF597 Gene

Disorders for ZNF597 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ZNF597 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tinea nigra
  • infection by cladosporium werneckii
inferior myocardial infarction
  • inferior wall myocardial infarction
cerebellar medulloblastoma
temple syndrome
  • uniparental disomy, maternal, chromosome 14
chromosome 2q37 deletion syndrome
  • albright hereditary osteodystrophy-like syndrome
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF597: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF597 Gene

Publications for ZNF597 Gene

  1. Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes. (PMID: 21593219) Nakabayashi K … Monk D (Human molecular genetics 2011) 3 4
  2. Molecular characterization and gene disruption of a novel zinc-finger protein, HIT-4, expressed in rodent brain. (PMID: 19968752) Tanabe Y … Nawa H (Journal of neurochemistry 2010) 2 3
  3. Analysis of allelic differential expression in human white blood cells. (PMID: 16467561) Pant PV … Frazer KA (Genome research 2006) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ZNF597 Gene

Sources for ZNF597 Gene