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Aliases for ZNF597 Gene

Aliases for ZNF597 Gene

  • Zinc Finger Protein 597 2 3 5
  • HIT-4 3

External Ids for ZNF597 Gene

Previous GeneCards Identifiers for ZNF597 Gene

  • GC16M003487
  • GC16M003426
  • GC16M003488
  • GC16M003467
  • GC16M003472
  • GC16M003475
  • GC16M003479
  • GC16M003481
  • GC16M003491
  • GC16M003494

Summaries for ZNF597 Gene

Entrez Gene Summary for ZNF597 Gene

  • This gene encodes a protein with multiple zinc finger domains. Loss of the related gene in rodents results in defects in neural development and embryonic lethality in mutant homozygotes. This gene is adjacent to a differentially methylated region (DMR) and is imprinted and maternally expressed. [provided by RefSeq, Nov 2015]

GeneCards Summary for ZNF597 Gene

ZNF597 (Zinc Finger Protein 597) is a Protein Coding gene. Diseases associated with ZNF597 include Hypotrichosis 1. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF200.

UniProtKB/Swiss-Prot for ZNF597 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF597 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF597 Gene

Genomics for ZNF597 Gene

GeneHancer (GH) Regulatory Elements for ZNF597 Gene

Promoters and enhancers for ZNF597 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I003442 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 580.9 -0.2 -184 2.2 ATF1 ZFP64 SIN3A YY1 ETS1 ELK1 FOS RUNX3 SP3 CEBPZ ZNF597 NAA60 ZNF200 CREBBP AMDHD2 ENSG00000261938 MEFV TIGD7 ZNF75A ZNF263
GH16I003003 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 49.4 +435.7 435726 8.4 HDGF HNRNPUL1 PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A LOC107984895 LOC105371056 CREBBP ZNF597 MMP25 AMDHD2 SRRM2 ZNF598 ZNF263 ZNF200
GH16I003400 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 41.3 +42.3 42323 2.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF174 ZSCAN32 ZNF597 TIGD7 CREBBP ZNF75A CLUAP1 ZNF200 MTCO1P28 SRRM2
GH16I003019 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 28.7 +421.2 421239 5.2 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC THOC6 HCFC1R1 TNFRSF12A ZNF263 ENSG00000261938 E4F1 SRRM2 TSC2 ERVK13-1 ZNF75A
GH16I004252 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 33.5 -810.1 -810107 1.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B LINC01569 LOC105371063 CREBBP ZNF500 ZNF263 ENSG00000261938 ZNF597 ZNF75A UBN1 ANKS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF597 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF597 gene promoter:

Genomic Locations for ZNF597 Gene

Genomic Locations for ZNF597 Gene
chr16:3,432,422-3,443,542
(GRCh38/hg38)
Size:
11,121 bases
Orientation:
Minus strand
chr16:3,486,104-3,493,542
(GRCh37/hg19)

Genomic View for ZNF597 Gene

Genes around ZNF597 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF597 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF597 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF597 Gene

Proteins for ZNF597 Gene

  • Protein details for ZNF597 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LX8-ZN597_HUMAN
    Recommended name:
    Zinc finger protein 597
    Protein Accession:
    Q96LX8

    Protein attributes for ZNF597 Gene

    Size:
    424 amino acids
    Molecular mass:
    48076 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF597 Gene

Post-translational modifications for ZNF597 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF597 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF597 Gene

Domains & Families for ZNF597 Gene

Gene Families for ZNF597 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF597 Gene

Suggested Antigen Peptide Sequences for ZNF597 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LX8

UniProtKB/Swiss-Prot:

ZN597_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF597: view

Function for ZNF597 Gene

Molecular function for ZNF597 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
UniProtKB/Swiss-Prot Induction:
Imprinted. Promoter methylation of the paternal allele may restrict expression to the maternal allele in leukocytes.

Phenotypes From GWAS Catalog for ZNF597 Gene

Gene Ontology (GO) - Molecular Function for ZNF597 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF597: view
genes like me logo Genes that share phenotypes with ZNF597: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF597 Gene

Localization for ZNF597 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF597 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF597 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF597 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF597: view

Pathways & Interactions for ZNF597 Gene

SuperPathways for ZNF597 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF597: view

Pathways by source for ZNF597 Gene

2 Reactome pathways for ZNF597 Gene

Gene Ontology (GO) - Biological Process for ZNF597 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF597: view

No data available for SIGNOR curated interactions for ZNF597 Gene

Drugs & Compounds for ZNF597 Gene

No Compound Related Data Available

Transcripts for ZNF597 Gene

mRNA/cDNA for ZNF597 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF597 Gene

Zinc finger protein 597:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF597 Gene

No ASD Table

Relevant External Links for ZNF597 Gene

GeneLoc Exon Structure for
ZNF597
ECgene alternative splicing isoforms for
ZNF597

Expression for ZNF597 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF597 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF597 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF597 Gene:

ZNF597

SOURCE GeneReport for Unigene cluster for ZNF597 Gene:

Hs.88630

Evidence on tissue expression from TISSUES for ZNF597 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF597: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF597 Gene

Orthologs for ZNF597 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF597 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF597 33 34
  • 98.82 (n)
dog
(Canis familiaris)
Mammalia ZNF597 33 34
  • 80.87 (n)
mouse
(Mus musculus)
Mammalia Zfp597 33 16 34
  • 76 (n)
rat
(Rattus norvegicus)
Mammalia Zfp597 33
  • 74.82 (n)
cow
(Bos Taurus)
Mammalia ZNF597 34
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF597 34
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR352258.1 34
  • 30 (a)
OneToMany
Species where no ortholog for ZNF597 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF597 Gene

ENSEMBL:
Gene Tree for ZNF597 (if available)
TreeFam:
Gene Tree for ZNF597 (if available)

Paralogs for ZNF597 Gene

Paralogs for ZNF597 Gene

(231) SIMAP similar genes for ZNF597 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF597: view

Variants for ZNF597 Gene

Sequence variations from dbSNP and Humsavar for ZNF597 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000055627 -- 3,443,745(-) A/C upstream_transcript_variant
rs1000111807 -- 3,444,239(-) G/T upstream_transcript_variant
rs1000163608 -- 3,440,006(-) G/C intron_variant
rs1000305342 -- 3,440,253(-) C/G intron_variant
rs1000516334 -- 3,441,015(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF597 Gene

Variant ID Type Subtype PubMed ID
esv29492 CNV gain 19812545
esv3637667 CNV gain 21293372
nsv1051957 CNV loss 25217958

Variation tolerance for ZNF597 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF597 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF597

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF597 Gene

Disorders for ZNF597 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF597 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypotrichosis 1
  • hypt1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF597

genes like me logo Genes that share disorders with ZNF597: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF597 Gene

Publications for ZNF597 Gene

  1. Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes. (PMID: 21593219) Nakabayashi K … Monk D (Human molecular genetics 2011) 3 4 58
  2. Molecular characterization and gene disruption of a novel zinc-finger protein, HIT-4, expressed in rodent brain. (PMID: 19968752) Tanabe Y … Nawa H (Journal of neurochemistry 2010) 2 3 58
  3. Analysis of allelic differential expression in human white blood cells. (PMID: 16467561) Pant PV … Frazer KA (Genome research 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ZNF597 Gene

Sources for ZNF597 Gene

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