Aliases for ZNF596 Gene

Aliases for ZNF596 Gene

  • Zinc Finger Protein 596 2 3 4 5
  • ZNF596 5

External Ids for ZNF596 Gene

Previous GeneCards Identifiers for ZNF596 Gene

  • GC08P000173
  • GC08P000174
  • GC08P000026

Summaries for ZNF596 Gene

GeneCards Summary for ZNF596 Gene

ZNF596 (Zinc Finger Protein 596) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF778.

UniProtKB/Swiss-Prot Summary for ZNF596 Gene

Additional gene information for ZNF596 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF596 Gene

Genomics for ZNF596 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF596 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF596 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF596

Top Transcription factor binding sites by QIAGEN in the ZNF596 gene promoter:
  • LyF-1
  • TBP

Genomic Locations for ZNF596 Gene

Genomic Locations for ZNF596 Gene
32,567 bases
Plus strand
15,206 bases
Plus strand

Genomic View for ZNF596 Gene

Genes around ZNF596 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF596 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF596 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF596 Gene

Proteins for ZNF596 Gene

  • Protein details for ZNF596 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 596
    Protein Accession:
    Secondary Accessions:
    • B2R8P4
    • O95015
    • Q8N9X0

    Protein attributes for ZNF596 Gene

    504 amino acids
    Molecular mass:
    58513 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD05197.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG36241.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF596 Gene


neXtProt entry for ZNF596 Gene

Post-translational modifications for ZNF596 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF596 Gene

Domains & Families for ZNF596 Gene

Gene Families for ZNF596 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF596 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF596 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 596 (ZN596_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF596: view

Function for ZNF596 Gene

Molecular function for ZNF596 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF596 Gene

Gene Ontology (GO) - Molecular Function for ZNF596 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF596: view
genes like me logo Genes that share phenotypes with ZNF596: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF596

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF596 Gene

Localization for ZNF596 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF596 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF596 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF596 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF596: view

Pathways & Interactions for ZNF596 Gene

genes like me logo Genes that share pathways with ZNF596: view

Pathways by source for ZNF596 Gene

2 Reactome pathways for ZNF596 Gene
1 KEGG pathway for ZNF596 Gene

Gene Ontology (GO) - Biological Process for ZNF596 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF596: view

No data available for SIGNOR curated interactions for ZNF596 Gene

Drugs & Compounds for ZNF596 Gene

No Compound Related Data Available

Transcripts for ZNF596 Gene

mRNA/cDNA for ZNF596 Gene

17 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF596

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF596 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - - - - - -
SP2: - - -
SP3: -
SP5: - - - -
SP6: - -
SP7: - -

Relevant External Links for ZNF596 Gene

GeneLoc Exon Structure for

Expression for ZNF596 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF596 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF596

SOURCE GeneReport for Unigene cluster for ZNF596 Gene:


Evidence on tissue expression from TISSUES for ZNF596 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF596: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF596 Gene

Orthologs for ZNF596 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF596 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF596 30 31
  • 99.27 (n)
(Bos Taurus)
Mammalia ZNF596 30
  • 81.79 (n)
-- 31
  • 43 (a)
(Canis familiaris)
Mammalia ZNF596 30 31
  • 81.53 (n)
Species where no ortholog for ZNF596 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF596 Gene

Gene Tree for ZNF596 (if available)
Gene Tree for ZNF596 (if available)
Evolutionary constrained regions (ECRs) for ZNF596: view image

Paralogs for ZNF596 Gene

(502) SIMAP similar genes for ZNF596 Gene using alignment to 7 proteins:

  • ZN596_HUMAN
genes like me logo Genes that share paralogs with ZNF596: view

Variants for ZNF596 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF596 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs2072174 - p.Val476Gly
rs2074718 - p.Thr136Lys

Additional dbSNP identifiers (rs#s) for ZNF596 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF596 Gene

Variant ID Type Subtype PubMed ID
dgv1350e214 CNV gain 21293372
dgv240e55 CNV gain 17911159
dgv6788n100 CNV gain 25217958
dgv6789n100 CNV gain 25217958
dgv6790n100 CNV gain 25217958
dgv6791n100 CNV gain 25217958
esv2759581 CNV gain+loss 17122850
esv2761228 CNV gain+loss 21179565
esv3576500 CNV gain 25503493
esv3615771 CNV gain 21293372
nsv1023686 CNV gain 25217958
nsv1030422 CNV gain 25217958
nsv1030576 CNV gain 25217958
nsv1031378 CNV loss 25217958
nsv428193 CNV gain+loss 18775914
nsv465263 CNV gain 19166990
nsv465264 CNV loss 19166990
nsv470163 CNV loss 18288195
nsv470164 CNV gain 18288195
nsv520036 CNV gain 19592680
nsv524542 CNV gain 19592680
nsv527387 CNV gain 19592680
nsv6034 CNV insertion 18451855
nsv609448 CNV loss 21841781
nsv609449 CNV gain 21841781
nsv609450 CNV gain 21841781
nsv609451 CNV loss 21841781
nsv609452 CNV loss 21841781
nsv8254 CNV gain 18304495
nsv831205 CNV loss 17160897
nsv831206 CNV loss 17160897

Variation tolerance for ZNF596 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.18; 80.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF596 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF596 Gene

Disorders for ZNF596 Gene

Additional Disease Information for ZNF596

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF596 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF596 Gene

Publications for ZNF596 Gene

  1. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF596 Gene

  • Boster Bio Antibodies for ZNF596
  • Boster Bio ELISA Kits for ZNF596

Sources for ZNF596 Gene