This gene encodes a protein belonging to the Cys2His2 zinc finger protein family, whose members function as transcription factors that can regulate a broad variety of developmental and cellular processes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013] See more...

Aliases for ZNF595 Gene

Aliases for ZNF595 Gene

  • Zinc Finger Protein 595 2 3 4 5

External Ids for ZNF595 Gene

Previous GeneCards Identifiers for ZNF595 Gene

  • GC04P000045

Summaries for ZNF595 Gene

Entrez Gene Summary for ZNF595 Gene

  • This gene encodes a protein belonging to the Cys2His2 zinc finger protein family, whose members function as transcription factors that can regulate a broad variety of developmental and cellular processes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]

GeneCards Summary for ZNF595 Gene

ZNF595 (Zinc Finger Protein 595) is a Protein Coding gene. Diseases associated with ZNF595 include Warburg Micro Syndrome 1 and Ciliary Dyskinesia, Primary, 4. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF493.

UniProtKB/Swiss-Prot Summary for ZNF595 Gene

Additional gene information for ZNF595 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF595 Gene

Genomics for ZNF595 Gene

GeneHancer (GH) Regulatory Elements for ZNF595 Gene

Promoters and enhancers for ZNF595 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J000050 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.4 374 6.1 EP300 FOS ZNF639 REST POLR2A ZBTB26 ZNF341 BCL11A NR2F2 TCF12 ZNF595 PIGG PCGF3 ZNF718 GAK ZNF141 lnc-ZNF732-9 piR-30821-047
GH04J000057 Enhancer 0.7 Ensembl ENCODE dbSUPER 0.7 +4.4 4369 1.1 NFXL1 CBX5 POLR2A ZNF595 piR-30821-047 lnc-ZNF732-9
GH04J000059 Enhancer 0.7 Ensembl ENCODE dbSUPER 0.4 +5.8 5815 0.6 TRIM28 TCF7L2 POLR2A ZNF595 lnc-ZNF732-9 piR-30821-047
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF595 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF595

Top Transcription factor binding sites by QIAGEN in the ZNF595 gene promoter:
  • AREB6
  • Brachyury
  • ER-alpha
  • FAC1
  • GATA-1
  • HOXA9B
  • Ik-3
  • Meis-1
  • Meis-1b
  • TBP

Genomic Locations for ZNF595 Gene

Genomic Locations for ZNF595 Gene
chr4:53,285-88,211
(GRCh38/hg38)
Size:
34,927 bases
Orientation:
Plus strand
chr4:53,179-88,099
(GRCh37/hg19)
Size:
34,921 bases
Orientation:
Plus strand

Genomic View for ZNF595 Gene

Genes around ZNF595 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF595 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF595 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF595 Gene

Proteins for ZNF595 Gene

  • Protein details for ZNF595 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYB9-ZN595_HUMAN
    Recommended name:
    Zinc finger protein 595
    Protein Accession:
    Q8IYB9
    Secondary Accessions:
    • Q7Z3I0

    Protein attributes for ZNF595 Gene

    Size:
    648 amino acids
    Molecular mass:
    74302 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF595 Gene

Post-translational modifications for ZNF595 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF595 Gene

No data available for DME Specific Peptides for ZNF595 Gene

Domains & Families for ZNF595 Gene

Gene Families for ZNF595 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF595 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF595 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 595 (ZN595_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IYB9

UniProtKB/Swiss-Prot:

ZN595_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF595: view

Function for ZNF595 Gene

Molecular function for ZNF595 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF595 Gene

Gene Ontology (GO) - Molecular Function for ZNF595 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF595: view
genes like me logo Genes that share phenotypes with ZNF595: view

Animal Models for ZNF595 Gene

MGI Knock Outs for ZNF595:
  • Zfp595 Zfp595<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF595 Gene

Localization for ZNF595 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF595 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF595 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF595 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF595: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF595 Gene

Pathways & Interactions for ZNF595 Gene

genes like me logo Genes that share pathways with ZNF595: view

Pathways by source for ZNF595 Gene

2 Reactome pathways for ZNF595 Gene
1 KEGG pathway for ZNF595 Gene

Gene Ontology (GO) - Biological Process for ZNF595 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF595: view

No data available for SIGNOR curated interactions for ZNF595 Gene

Drugs & Compounds for ZNF595 Gene

No Compound Related Data Available

Transcripts for ZNF595 Gene

mRNA/cDNA for ZNF595 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF595 Gene

No ASD Table

Relevant External Links for ZNF595 Gene

GeneLoc Exon Structure for
ZNF595

Expression for ZNF595 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF595 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF595

SOURCE GeneReport for Unigene cluster for ZNF595 Gene:

Hs.709469
genes like me logo Genes that share expression patterns with ZNF595: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF595 Gene

Orthologs for ZNF595 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for ZNF595 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF595 30
  • 99.25 (n)
mouse
(Mus musculus)
Mammalia Zfp595 17 30
  • 67.05 (n)
Species where no ortholog for ZNF595 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF595 Gene

ENSEMBL:
Gene Tree for ZNF595 (if available)
TreeFam:
Gene Tree for ZNF595 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF595: view image

Paralogs for ZNF595 Gene

Paralogs for ZNF595 Gene

(477) SIMAP similar genes for ZNF595 Gene using alignment to 4 proteins:

  • ZN595_HUMAN
  • E9PN20_HUMAN
  • F5H663_HUMAN
  • Q7Z3I0_HUMAN

Pseudogenes.org Pseudogenes for ZNF595 Gene

genes like me logo Genes that share paralogs with ZNF595: view

Variants for ZNF595 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF595 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs1553801175 Not Provided: not provided 86,075(+) AC/A FRAMESHIFT_VARIANT
rs1553801178 Not Provided: not provided 86,078(+) G/GA FRAMESHIFT_VARIANT
rs2006764 - p.Ala628Gly

Additional dbSNP identifiers (rs#s) for ZNF595 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF595 Gene

Variant ID Type Subtype PubMed ID
dgv114e203 CNV loss 21179565
dgv115e203 CNV gain 21179565
dgv1447e212 CNV gain 25503493
dgv186n111 CNV duplication 26073780
dgv2696n106 CNV duplication 24896259
dgv2697n106 CNV deletion 24896259
dgv2909e59 CNV duplication 20981092
dgv5054n100 CNV loss 25217958
dgv5055n100 CNV gain+loss 25217958
dgv5056n100 CNV gain 25217958
dgv5057n100 CNV gain 25217958
dgv5058n100 CNV gain+loss 25217958
dgv5059n100 CNV gain 25217958
dgv5060n100 CNV gain 25217958
dgv5061n100 CNV gain 25217958
dgv5062n100 CNV loss 25217958
dgv5063n100 CNV gain 25217958
dgv5064n100 CNV gain 25217958
dgv5065n100 CNV loss 25217958
dgv5066n100 CNV gain+loss 25217958
dgv5067n100 CNV loss 25217958
dgv5068n100 CNV loss 25217958
dgv5069n100 CNV gain 25217958
dgv5070n100 CNV gain 25217958
dgv5071n100 CNV gain 25217958
esv2420576 CNV deletion 18987734
esv2460685 CNV deletion 19546169
esv2671718 CNV deletion 23128226
esv2752043 CNV gain 17911159
esv2759216 CNV gain+loss 17122850
esv2762400 CNV gain 21179565
esv2763806 CNV gain+loss 21179565
esv33512 CNV gain 17666407
esv3563201 CNV deletion 23714750
esv3599345 CNV loss 21293372
esv3599346 CNV gain 21293372
esv3599347 CNV loss 21293372
esv3893860 CNV loss 25118596
esv3893861 CNV gain 25118596
esv5403 OTHER complex 18987735
esv7180 CNV loss 19470904
nsv1001899 CNV loss 25217958
nsv1011039 CNV loss 25217958
nsv1013934 CNV gain 25217958
nsv1014885 CNV gain 25217958
nsv10409 CNV loss 18304495
nsv1074122 CNV deletion 25765185
nsv1074123 CNV deletion 25765185
nsv1078529 CNV duplication 25765185
nsv1114476 CNV deletion 24896259
nsv1114477 CNV deletion 24896259
nsv1146011 CNV duplication 26484159
nsv1150471 CNV deletion 26484159
nsv1161025 CNV deletion 26073780
nsv461141 CNV gain 19166990
nsv473272 CNV novel sequence insertion 20440878
nsv516451 CNV gain+loss 19592680
nsv593189 CNV gain 21841781
nsv593190 CNV gain 21841781
nsv593191 CNV gain 21841781
nsv818206 CNV loss 17921354
nsv821633 CNV gain 15273396
nsv950322 CNV duplication 24416366
nsv956325 CNV deletion 24416366
nsv967715 CNV duplication 23825009
nsv967821 CNV duplication 23825009
nsv980174 CNV duplication 23825009

Variation tolerance for ZNF595 Gene

Gene Damage Index Score: 0.71; 15.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF595 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF595

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF595 Gene

Disorders for ZNF595 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ZNF595 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF595

genes like me logo Genes that share disorders with ZNF595: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF595 Gene

Publications for ZNF595 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54
  5. Cys2His2 zinc finger protein family: classification, functions, and major members. (PMID: 22803940) Razin SV … Kantidze OL (Biochemistry. Biokhimiia 2012) 3 54

Products for ZNF595 Gene

Sources for ZNF595 Gene