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Aliases for ZNF594 Gene

Aliases for ZNF594 Gene

  • Zinc Finger Protein 594 2 3 5
  • Zinc Finger Protein HZF18 4
  • KIAA1871 4

External Ids for ZNF594 Gene

Previous GeneCards Identifiers for ZNF594 Gene

  • GC17M005284
  • GC17M005023
  • GC17M005082

Summaries for ZNF594 Gene

GeneCards Summary for ZNF594 Gene

ZNF594 (Zinc Finger Protein 594) is a Protein Coding gene. An important paralog of this gene is ZNF850.

UniProtKB/Swiss-Prot for ZNF594 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF594 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF594 Gene

Genomics for ZNF594 Gene

GeneHancer (GH) Regulatory Elements for ZNF594 Gene

Promoters and enhancers for ZNF594 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I005191 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 583.1 0.0 -18 1.8 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 POLR2B ZNF213 ZNF594 LOC100130950 LOC101927979 RPAIN ZNF232 ANKFY1 MIS12 PELP1 RABEP1 DERL2
GH17I004985 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 27.4 +204.3 204294 3.7 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 CAMTA2 ENSG00000262678 LOC101927979 ZNF594 LOC100130950 CHRNE ZNF232 DERL2 NUP88 MIS12
GH17I005416 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 19.9 -227.1 -227068 4.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B IRF4 YY1 RPAIN NUP88 RABEP1 ZNF594 ENSG00000263272 ENSG00000263220 C1QBP DHX33 PELP1 LOC101927979
GH17I004262 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 20 +928.2 928186 2.3 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A DMAP1 YY1 SLC30A9 POLR2B ANKFY1 ZNF232 LOC101927979 LOC100130950 ZNF594 LOC105371492 ENSG00000263164 MYBBP1A CYB5D2 RYKP1
GH17I004786 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.1 +403.1 403144 5.3 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 E2F8 ZNF207 ZNF143 VMO1 ENSG00000280254 GLTPD2 ZNF594 LOC100130950 PELP1 RNF167 PSMB6 GC17M004737
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF594 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF594 gene promoter:

Genomic Locations for ZNF594 Gene

Genomic Locations for ZNF594 Gene
chr17:5,179,535-5,191,883
(GRCh38/hg38)
Size:
12,349 bases
Orientation:
Minus strand
chr17:5,082,831-5,095,178
(GRCh37/hg19)

Genomic View for ZNF594 Gene

Genes around ZNF594 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF594 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF594 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF594 Gene

Proteins for ZNF594 Gene

  • Protein details for ZNF594 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JF6-ZN594_HUMAN
    Recommended name:
    Zinc finger protein 594
    Protein Accession:
    Q96JF6
    Secondary Accessions:
    • Q6RFS0

    Protein attributes for ZNF594 Gene

    Size:
    807 amino acids
    Molecular mass:
    93907 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47500.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF594 Gene

Post-translational modifications for ZNF594 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF594 Gene

No data available for DME Specific Peptides for ZNF594 Gene

Domains & Families for ZNF594 Gene

Gene Families for ZNF594 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF594 Gene

Suggested Antigen Peptide Sequences for ZNF594 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JF6

UniProtKB/Swiss-Prot:

ZN594_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF594: view

Function for ZNF594 Gene

Molecular function for ZNF594 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF594 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF594: view

Phenotypes for ZNF594 Gene

GenomeRNAi human phenotypes for ZNF594:
genes like me logo Genes that share phenotypes with ZNF594: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF594 Gene

Localization for ZNF594 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF594 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF594 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF594 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF594: view

Pathways & Interactions for ZNF594 Gene

SuperPathways for ZNF594 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF594 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF594: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF594 Gene

Drugs & Compounds for ZNF594 Gene

No Compound Related Data Available

Transcripts for ZNF594 Gene

Unigene Clusters for ZNF594 Gene

Zinc finger protein 594:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF594 Gene

No ASD Table

Relevant External Links for ZNF594 Gene

GeneLoc Exon Structure for
ZNF594
ECgene alternative splicing isoforms for
ZNF594

Expression for ZNF594 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF594 Gene

Protein differential expression in normal tissues from HIPED for ZNF594 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF594 Gene



Protein tissue co-expression partners for ZNF594 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF594 Gene:

ZNF594

SOURCE GeneReport for Unigene cluster for ZNF594 Gene:

Hs.658402

Evidence on tissue expression from TISSUES for ZNF594 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF594: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF594 Gene

Orthologs for ZNF594 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF594 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF594 33
  • 99.3 (n)
-- 34
  • 45 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia ZNF594 34
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF397 34
  • 50 (a)
OneToMany
ZNF192 34
  • 36 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp442 34
  • 45 (a)
ManyToMany
4930522L14Rik 34
  • 44 (a)
ManyToMany
Zfp873 34
  • 44 (a)
ManyToMany
Gm5141 34
  • 43 (a)
ManyToMany
Zfp808 34
  • 42 (a)
ManyToMany
Zfp788 34
  • 36 (a)
ManyToMany
Zfp26 34
  • 33 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia ZNF252 34
  • 38 (a)
ManyToMany
Species where no ortholog for ZNF594 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF594 Gene

ENSEMBL:
Gene Tree for ZNF594 (if available)
TreeFam:
Gene Tree for ZNF594 (if available)

Paralogs for ZNF594 Gene

(509) SIMAP similar genes for ZNF594 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF594: view

Variants for ZNF594 Gene

Sequence variations from dbSNP and Humsavar for ZNF594 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000264797 -- 5,186,237(-) G/A/C intron_variant
rs1000471323 -- 5,191,959(-) C/T upstream_transcript_variant
rs1000574711 -- 5,187,326(-) A/G intron_variant
rs1000605931 -- 5,187,080(-) T/A intron_variant
rs1000719030 -- 5,177,197(-) T/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF594 Gene

Variant ID Type Subtype PubMed ID
dgv3089n100 CNV gain 25217958
dgv526e199 CNV deletion 23128226
esv3639807 CNV loss 21293372
nsv574273 CNV gain 21841781
nsv960045 CNV duplication 23825009

Variation tolerance for ZNF594 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF594 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF594

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF594 Gene

Disorders for ZNF594 Gene

Additional Disease Information for ZNF594

No disorders were found for ZNF594 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF594 Gene

Publications for ZNF594 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 3 4 58
  3. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. (PMID: 25925205) Bhattacharya S … Ghosh MK (Cellular oncology (Dordrecht) 2015) 3 58
  4. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) König R … Chanda SK (Cell 2008) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF594 Gene

Sources for ZNF594 Gene

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