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Aliases for ZNF589 Gene

Aliases for ZNF589 Gene

  • Zinc Finger Protein 589 2 3 5
  • Stem Cell Zinc Finger Protein 1 3 4
  • SZF1 3 4
  • KRAB-Zinc Finger Protein SZF1-1 3
  • EC 2.1.1.43 56

External Ids for ZNF589 Gene

Previous GeneCards Identifiers for ZNF589 Gene

  • GC03P048244
  • GC03P048257
  • GC03P048282

Summaries for ZNF589 Gene

GeneCards Summary for ZNF589 Gene

ZNF589 (Zinc Finger Protein 589) is a Protein Coding gene. Diseases associated with ZNF589 include Kleefstra Syndrome. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF343.

UniProtKB/Swiss-Prot for ZNF589 Gene

  • May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.

Additional gene information for ZNF589 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF589 Gene

Genomics for ZNF589 Gene

GeneHancer (GH) Regulatory Elements for ZNF589 Gene

Promoters and enhancers for ZNF589 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I048239 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 641.7 -0.2 -176 2.8 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF589 GC03M048234 QRICH1 NME6 CCDC71 ATRIP PTPN23 USP19 MRPS18AP1 TMEM89
GH03I048186 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 82.1 -53.2 -53185 2.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 E2F8 ZNF143 FOS CDC25A ZNF589 QRICH1 ATRIP USP19 TMEM89 CCDC71 PTPN23 NME6 MRPS18AP1
GH03I048299 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 62.8 +60.3 60347 3.4 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B NME6 ZNF589 FCF1P2 BOLA2P2 ENSG00000235236 ENSG00000260236 IP6K2 PTPN23
GH03I048085 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 35.3 -153.2 -153199 5.3 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF263 MAP4 ATRIP DHX30 ZNF589 ENSG00000235236 SETD2 PTPN23 TMEM89 KLHL18 ENSG00000260236
GH03I049016 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 31.5 +779.2 779161 6.8 CLOCK ZFP64 FEZF1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZFP41 DALRD3 GC03M049024 MIR191 NDUFAF3 MIR425 WDR6 ENSG00000235236 NICN1 ENSG00000223343 P4HTM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF589 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF589 gene promoter:

Genomic Locations for ZNF589 Gene

Genomic Locations for ZNF589 Gene
chr3:48,241,100-48,299,253
(GRCh38/hg38)
Size:
58,154 bases
Orientation:
Plus strand
chr3:48,282,590-48,340,743
(GRCh37/hg19)

Genomic View for ZNF589 Gene

Genes around ZNF589 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF589 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF589 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF589 Gene

Proteins for ZNF589 Gene

  • Protein details for ZNF589 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UQ0-ZN589_HUMAN
    Recommended name:
    Zinc finger protein 589
    Protein Accession:
    Q86UQ0
    Secondary Accessions:
    • Q86UC9
    • Q9BRI6
    • Q9BRY3
    • Q9Y611
    • Q9Y612

    Protein attributes for ZNF589 Gene

    Size:
    364 amino acids
    Molecular mass:
    41189 Da
    Quaternary structure:
    • Interacts with TRIM28.
    SequenceCaution:
    • Sequence=AAH05859.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH06247.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH48798.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF589 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF589 Gene

Selected DME Specific Peptides for ZNF589 Gene

Q86UQ0:
  • HQRTHTGEKPY
  • CRECGRGF

Post-translational modifications for ZNF589 Gene

No Post-translational modifications

Domains & Families for ZNF589 Gene

Gene Families for ZNF589 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF589 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UQ0

UniProtKB/Swiss-Prot:

ZN589_HUMAN :
  • The KRAB domain mediates interaction with TRIM28.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The KRAB domain mediates interaction with TRIM28.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF589: view

Function for ZNF589 Gene

Molecular function for ZNF589 Gene

UniProtKB/Swiss-Prot Function:
May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.

Enzyme Numbers (IUBMB) for ZNF589 Gene

Phenotypes From GWAS Catalog for ZNF589 Gene

Gene Ontology (GO) - Molecular Function for ZNF589 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP 12097288
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP 12097288
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF589: view
genes like me logo Genes that share phenotypes with ZNF589: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF589 Gene

Localization for ZNF589 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF589 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF589 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF589 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,IEA 23665872
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF589: view

Pathways & Interactions for ZNF589 Gene

SuperPathways for ZNF589 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF589: view

Pathways by source for ZNF589 Gene

2 Reactome pathways for ZNF589 Gene

Gene Ontology (GO) - Biological Process for ZNF589 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 12097288
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF589: view

No data available for SIGNOR curated interactions for ZNF589 Gene

Drugs & Compounds for ZNF589 Gene

No Compound Related Data Available

Transcripts for ZNF589 Gene

Unigene Clusters for ZNF589 Gene

Zinc finger protein 589:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF589 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1:
SP2: - - - - - - -
SP3: - -
SP4: - -
SP5: - - - - - -
SP6:

Relevant External Links for ZNF589 Gene

GeneLoc Exon Structure for
ZNF589
ECgene alternative splicing isoforms for
ZNF589

Expression for ZNF589 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF589 Gene

Protein differential expression in normal tissues from HIPED for ZNF589 Gene

This gene is overexpressed in Fetal gut (32.5) and Testis (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF589 Gene



Protein tissue co-expression partners for ZNF589 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF589 Gene:

ZNF589

SOURCE GeneReport for Unigene cluster for ZNF589 Gene:

Hs.172602

mRNA Expression by UniProt/SwissProt for ZNF589 Gene:

Q86UQ0-ZN589_HUMAN
Tissue specificity: Isoform 2 is widely expressed. Isoform 3 is only expressed in CD34(+) cells.

Evidence on tissue expression from TISSUES for ZNF589 Gene

  • Lung(4.2)
  • Lymph node(4.2)
  • Muscle(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZNF589: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF589 Gene

Orthologs for ZNF589 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF589 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF589 33 34
  • 98.81 (n)
Species where no ortholog for ZNF589 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF589 Gene

ENSEMBL:
Gene Tree for ZNF589 (if available)
TreeFam:
Gene Tree for ZNF589 (if available)

Paralogs for ZNF589 Gene

Paralogs for ZNF589 Gene

(564) SIMAP similar genes for ZNF589 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF589 Gene

genes like me logo Genes that share paralogs with ZNF589: view

Variants for ZNF589 Gene

Sequence variations from dbSNP and Humsavar for ZNF589 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000076173 -- 48,271,649(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000096079 -- 48,263,703(+) G/T intron_variant
rs1000116200 -- 48,258,818(+) G/A intron_variant
rs1000166995 -- 48,252,625(+) /C genic_upstream_transcript_variant, intron_variant
rs1000252678 -- 48,258,266(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF589 Gene

Variant ID Type Subtype PubMed ID
nsv834683 CNV gain 17160897
nsv834682 CNV gain 17160897
nsv474252 CNV novel sequence insertion 20440878
nsv472083 CNV novel sequence insertion 20440878
esv3596103 CNV loss 21293372

Variation tolerance for ZNF589 Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.79; 73.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF589 Gene

Human Gene Mutation Database (HGMD)
ZNF589
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF589

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF589 Gene

Disorders for ZNF589 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF589 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
kleefstra syndrome
  • 9q subtelomeric deletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF589

genes like me logo Genes that share disorders with ZNF589: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF589 Gene

Publications for ZNF589 Gene

  1. SZF1: a novel KRAB-zinc finger gene expressed in CD34+ stem/progenitor cells. (PMID: 10029171) Liu C … Small D (Experimental hematology 1999) 2 3 4 22 58
  2. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W … Huang Z (Cellular and molecular life sciences : CMLS 2013) 3 4 58
  3. A common DNA-binding site for SZF1 and the BRCA1-associated zinc finger protein, ZBRK1. (PMID: 12097288) Peng H … Rauscher FJ (Cancer research 2002) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The stem cell zinc finger 1 (SZF1)/ZNF589 protein has a human-specific evolutionary nucleotide DNA change and acts as a regulator of cell viability in the hematopoietic system. (PMID: 26738774) Venturini L … Ganser A (Experimental hematology 2016) 3 58

Products for ZNF589 Gene

Sources for ZNF589 Gene

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