Aliases for ZNF587B Gene

Aliases for ZNF587B Gene

  • Zinc Finger Protein 587B 2 3 4 5
  • ZNF587B 5

External Ids for ZNF587B Gene

Previous GeneCards Identifiers for ZNF587B Gene

  • GC19P058334

Summaries for ZNF587B Gene

GeneCards Summary for ZNF587B Gene

ZNF587B (Zinc Finger Protein 587B) is a Protein Coding gene. Diseases associated with ZNF587B include Myeloproliferative Syndrome, Transient. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF552.

UniProtKB/Swiss-Prot Summary for ZNF587B Gene

Additional gene information for ZNF587B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF587B Gene

Genomics for ZNF587B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF587B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF587B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF587B

Genomic Locations for ZNF587B Gene

Genomic Locations for ZNF587B Gene
chr19:57,819,721-57,846,238
(GRCh38/hg38)
Size:
26,518 bases
Orientation:
Plus strand
chr19:58,331,099-58,370,018
(GRCh37/hg19)
Size:
38,920 bases
Orientation:
Plus strand

Genomic View for ZNF587B Gene

Genes around ZNF587B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF587B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF587B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF587B Gene

Proteins for ZNF587B Gene

  • Protein details for ZNF587B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E7ETH6-Z587B_HUMAN
    Recommended name:
    Zinc finger protein 587B
    Protein Accession:
    E7ETH6
    Secondary Accessions:
    • B4DR41

    Protein attributes for ZNF587B Gene

    Size:
    402 amino acids
    Molecular mass:
    45541 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF587B Gene

Post-translational modifications for ZNF587B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF587B Gene

No data available for DME Specific Peptides for ZNF587B Gene

Domains & Families for ZNF587B Gene

Gene Families for ZNF587B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF587B Gene

Graphical View of Domain Structure for InterPro Entry

E7ETH6

UniProtKB/Swiss-Prot:

Z587B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF587B: view

No data available for Suggested Antigen Peptide Sequences for ZNF587B Gene

Function for ZNF587B Gene

Molecular function for ZNF587B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF587B Gene

Gene Ontology (GO) - Molecular Function for ZNF587B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF587B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF587B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF587B Gene

Localization for ZNF587B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF587B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF587B gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF587B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF587B: view

Pathways & Interactions for ZNF587B Gene

PathCards logo

SuperPathways for ZNF587B Gene

No Data Available

Interacting Proteins for ZNF587B Gene

Gene Ontology (GO) - Biological Process for ZNF587B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF587B: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF587B Gene

Drugs & Compounds for ZNF587B Gene

No Compound Related Data Available

Transcripts for ZNF587B Gene

mRNA/cDNA for ZNF587B Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF587B

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF587B Gene

No ASD Table

Relevant External Links for ZNF587B Gene

GeneLoc Exon Structure for
ZNF587B

Expression for ZNF587B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF587B Gene

Protein differential expression in normal tissues from HIPED for ZNF587B Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF587B Gene



Protein tissue co-expression partners for ZNF587B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF587B

SOURCE GeneReport for Unigene cluster for ZNF587B Gene:

Hs.658251
genes like me logo Genes that share expression patterns with ZNF587B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF587B Gene

Orthologs for ZNF587B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF587B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF587B 31
  • 48 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 38 (a)
OneToMany
Species where no ortholog for ZNF587B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF587B Gene

ENSEMBL:
Gene Tree for ZNF587B (if available)
TreeFam:
Gene Tree for ZNF587B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF587B: view image

Paralogs for ZNF587B Gene

(527) SIMAP similar genes for ZNF587B Gene using alignment to 4 proteins:

  • Z587B_HUMAN
  • F8W6R8_HUMAN
  • M0QY62_HUMAN
  • M0R1N2_HUMAN
genes like me logo Genes that share paralogs with ZNF587B: view

Variants for ZNF587B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF587B Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
713407 Benign: not provided 57,839,084(+) G/A MISSENSE_VARIANT
781537 Benign: not provided 57,841,386(+) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF587B Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF587B Gene

Variant ID Type Subtype PubMed ID
dgv3686n100 CNV gain 25217958
esv2763213 CNV gain 21179565
esv3644912 CNV loss 21293372
esv3893258 CNV gain 25118596
nsv1055845 CNV gain 25217958
nsv1066059 CNV gain 25217958
nsv1134816 CNV deletion 24896259
nsv7311 OTHER inversion 18451855
nsv961251 CNV duplication 23825009

Variation tolerance for ZNF587B Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF587B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF587B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF587B Gene

Disorders for ZNF587B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF587B Gene - From: DISEASES

Disorder Aliases PubMed IDs
myeloproliferative syndrome, transient
  • mst
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF587B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF587B Gene

Publications for ZNF587B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  3. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3
  4. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks IA … Vertegaal AC (Nature structural & molecular biology 2014) 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF587B Gene

Sources for ZNF587B Gene