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Aliases for ZNF587B Gene

Aliases for ZNF587B Gene

  • Zinc Finger Protein 587B 2 3 5

External Ids for ZNF587B Gene

Previous GeneCards Identifiers for ZNF587B Gene

  • GC19P058334

Summaries for ZNF587B Gene

GeneCards Summary for ZNF587B Gene

ZNF587B (Zinc Finger Protein 587B) is a Protein Coding gene. Diseases associated with ZNF587B include Myeloproliferative Syndrome, Transient. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF552.

UniProtKB/Swiss-Prot for ZNF587B Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF587B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF587B Gene

Genomics for ZNF587B Gene

GeneHancer (GH) Regulatory Elements for ZNF587B Gene

Promoters and enhancers for ZNF587B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057828 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.4 +10.1 10112 2.6 FOXA2 ZFP64 SIN3A DMAP1 ZBTB40 RAD21 YY1 ETS1 ZNF143 THAP11 ZNF587B ENSG00000269867 ZNF587 ZNF586 ZNF211 FKBP1AP1 ENSG00000268750 PIR39821
GH19I057818 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 550.8 +0.0 44 3.3 PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ENSG00000268750 ZNF587B ENSG00000269867 TRIM28 ZNF264 ZNF805 ZNF543 ZNF587 ZNF749 ZNF549
GH19I058553 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.6 +737.4 737372 7.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CHMP2A UBE2M TRIM28 ZNF417 ZNF134 ZNF606 ZNF274 MZF1 LOC100128398 ERVK3-1
GH19I058379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.1 +561.3 561344 2.9 ZFP64 FEZF1 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF837 LOC100128398 ZNF606 ZNF329 ZNF135 TRIM28 ZNF132 ZNF446 ZSCAN18 ZNF548
GH19I058361 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.9 +542.7 542664 2.1 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B LOC105372483 ENSG00000268230 RNA5SP473 ZNF497 ZNF548 ZNF417 ZNF134 TRIM28 ZSCAN22 ZNF274
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF587B on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF587B Gene

Genomic Locations for ZNF587B Gene
chr19:57,819,741-57,846,238
(GRCh38/hg38)
Size:
26,498 bases
Orientation:
Plus strand
chr19:58,331,099-58,370,018
(GRCh37/hg19)

Genomic View for ZNF587B Gene

Genes around ZNF587B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF587B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF587B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF587B Gene

Proteins for ZNF587B Gene

  • Protein details for ZNF587B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E7ETH6-Z587B_HUMAN
    Recommended name:
    Zinc finger protein 587B
    Protein Accession:
    E7ETH6
    Secondary Accessions:
    • B4DR41

    Protein attributes for ZNF587B Gene

    Size:
    402 amino acids
    Molecular mass:
    45541 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF587B Gene

Post-translational modifications for ZNF587B Gene

No Post-translational modifications

Other Protein References for ZNF587B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF587B Gene

Domains & Families for ZNF587B Gene

Gene Families for ZNF587B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF587B Gene

Graphical View of Domain Structure for InterPro Entry

E7ETH6

UniProtKB/Swiss-Prot:

Z587B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF587B: view

No data available for Suggested Antigen Peptide Sequences for ZNF587B Gene

Function for ZNF587B Gene

Molecular function for ZNF587B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF587B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF587B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF587B Gene

Localization for ZNF587B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF587B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF587B gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF587B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF587B: view

Pathways & Interactions for ZNF587B Gene

SuperPathways for ZNF587B Gene

No Data Available

Interacting Proteins for ZNF587B Gene

Gene Ontology (GO) - Biological Process for ZNF587B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF587B: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF587B Gene

Drugs & Compounds for ZNF587B Gene

No Compound Related Data Available

Transcripts for ZNF587B Gene

mRNA/cDNA for ZNF587B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF587B Gene

Zinc finger protein 587B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF587B Gene

No ASD Table

Relevant External Links for ZNF587B Gene

GeneLoc Exon Structure for
ZNF587B
ECgene alternative splicing isoforms for
ZNF587B

Expression for ZNF587B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF587B Gene

Protein differential expression in normal tissues from HIPED for ZNF587B Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF587B Gene



Protein tissue co-expression partners for ZNF587B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF587B Gene:

ZNF587B

SOURCE GeneReport for Unigene cluster for ZNF587B Gene:

Hs.658251
genes like me logo Genes that share expression patterns with ZNF587B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF587B Gene

Orthologs for ZNF587B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF587B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF587B 34
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 38 (a)
OneToMany
Species where no ortholog for ZNF587B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF587B Gene

ENSEMBL:
Gene Tree for ZNF587B (if available)
TreeFam:
Gene Tree for ZNF587B (if available)

Paralogs for ZNF587B Gene

(527) SIMAP similar genes for ZNF587B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF587B: view

Variants for ZNF587B Gene

Sequence variations from dbSNP and Humsavar for ZNF587B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000292881 -- 57,830,984(+) A/G intron_variant
rs1000293255 -- 57,841,976(+) A/G intron_variant
rs1000457341 -- 57,837,138(+) C/A intron_variant
rs1000574512 -- 57,838,294(+) T/TT intron_variant
rs1000636782 -- 57,831,747(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF587B Gene

Variant ID Type Subtype PubMed ID
dgv3686n100 CNV gain 25217958
esv2763213 CNV gain 21179565
esv3644912 CNV loss 21293372
esv3893258 CNV gain 25118596
nsv1055845 CNV gain 25217958
nsv1066059 CNV gain 25217958
nsv1134816 CNV deletion 24896259
nsv7311 OTHER inversion 18451855
nsv961251 CNV duplication 23825009

Variation tolerance for ZNF587B Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF587B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF587B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF587B Gene

Disorders for ZNF587B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF587B Gene - From: DISEASES

Disorder Aliases PubMed IDs
myeloproliferative syndrome, transient
  • mst
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF587B

genes like me logo Genes that share disorders with ZNF587B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF587B Gene

Publications for ZNF587B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks IA … Vertegaal AC (Nature structural & molecular biology 2014) 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  5. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F … Gauthier JM (Genome research 2004) 3 58

Products for ZNF587B Gene

Sources for ZNF587B Gene

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