Aliases for ZNF587 Gene

Aliases for ZNF587 Gene

  • Zinc Finger Protein 587 2 3 4 5
  • ZF6 2 3
  • Zinc Finger Protein Zfp6 3
  • FLJ14710 2
  • FLJ20813 2
  • ZNF587 5
  • UBF-Fl 2

External Ids for ZNF587 Gene

Previous GeneCards Identifiers for ZNF587 Gene

  • GC19P063054
  • GC19P063055
  • GC19P058361
  • GC19P054672
  • GC19P058333

Summaries for ZNF587 Gene

GeneCards Summary for ZNF587 Gene

ZNF587 (Zinc Finger Protein 587) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF417.

UniProtKB/Swiss-Prot Summary for ZNF587 Gene

Additional gene information for ZNF587 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF587 Gene

Genomics for ZNF587 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF587 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF587 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF587

Top Transcription factor binding sites by QIAGEN in the ZNF587 gene promoter:
  • HTF
  • XBP-1

Genomic Locations for ZNF587 Gene

Genomic Locations for ZNF587 Gene
chr19:57,849,859-57,865,117
(GRCh38/hg38)
Size:
15,259 bases
Orientation:
Plus strand
chr19:58,361,181-58,376,491
(GRCh37/hg19)
Size:
15,311 bases
Orientation:
Plus strand

Genomic View for ZNF587 Gene

Genes around ZNF587 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF587 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF587 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF587 Gene

Proteins for ZNF587 Gene

  • Protein details for ZNF587 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SQ5-ZN587_HUMAN
    Recommended name:
    Zinc finger protein 587
    Protein Accession:
    Q96SQ5
    Secondary Accessions:
    • A0AV72
    • G3V0H5
    • Q6ZMK8

    Protein attributes for ZNF587 Gene

    Size:
    575 amino acids
    Molecular mass:
    65622 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF587 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF587 Gene

Post-translational modifications for ZNF587 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF587 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF587 Gene

Domains & Families for ZNF587 Gene

Gene Families for ZNF587 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF587 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF587 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein zfp6 (Q92967_HUMAN)
  • Zinc finger protein 587 (ZN587_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96SQ5

UniProtKB/Swiss-Prot:

ZN587_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF587: view

Function for ZNF587 Gene

Molecular function for ZNF587 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF587 Gene

Gene Ontology (GO) - Molecular Function for ZNF587 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF587: view
genes like me logo Genes that share phenotypes with ZNF587: view

Animal Model Products

CRISPR Products

miRNA for ZNF587 Gene

miRTarBase miRNAs that target ZNF587

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF587

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF587 Gene

Localization for ZNF587 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF587 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF587 gene
Compartment Confidence
nucleus 4
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF587 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF587: view

Pathways & Interactions for ZNF587 Gene

genes like me logo Genes that share pathways with ZNF587: view

Pathways by source for ZNF587 Gene

2 Reactome pathways for ZNF587 Gene
1 KEGG pathway for ZNF587 Gene

Gene Ontology (GO) - Biological Process for ZNF587 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF587: view

No data available for SIGNOR curated interactions for ZNF587 Gene

Drugs & Compounds for ZNF587 Gene

No Compound Related Data Available

Transcripts for ZNF587 Gene

mRNA/cDNA for ZNF587 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF587

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF587 Gene

No ASD Table

Relevant External Links for ZNF587 Gene

GeneLoc Exon Structure for
ZNF587

Expression for ZNF587 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF587 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF587

SOURCE GeneReport for Unigene cluster for ZNF587 Gene:

Hs.642598

Evidence on tissue expression from TISSUES for ZNF587 Gene

  • Nervous system(4.9)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with ZNF587: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF587 Gene

Orthologs for ZNF587 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF587 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 97 (a)
ManyToMany
-- 31
  • 96 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 52 (a)
OneToMany
Species where no ortholog for ZNF587 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF587 Gene

ENSEMBL:
Gene Tree for ZNF587 (if available)
TreeFam:
Gene Tree for ZNF587 (if available)

Paralogs for ZNF587 Gene

(518) SIMAP similar genes for ZNF587 Gene using alignment to 2 proteins:

  • ZN587_HUMAN
  • E7EP41_HUMAN

Pseudogenes.org Pseudogenes for ZNF587 Gene

genes like me logo Genes that share paralogs with ZNF587: view

Variants for ZNF587 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF587 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769061 Benign: not provided 57,859,359(+) T/G MISSENSE_VARIANT
769062 Benign: not provided 57,859,768(+) G/C SYNONYMOUS_VARIANT
774741 Benign: not provided 57,859,398(+) G/A MISSENSE_VARIANT
774742 Benign: not provided 57,859,906(+) G/T SYNONYMOUS_VARIANT
779472 Benign: not provided 57,858,894(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF587 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF587 Gene

Variant ID Type Subtype PubMed ID
dgv3686n100 CNV gain 25217958
esv2656978 CNV deletion 23128226
esv2763213 CNV gain 21179565
esv3644912 CNV loss 21293372
esv3893258 CNV gain 25118596
nsv1055845 CNV gain 25217958
nsv1066059 CNV gain 25217958
nsv7311 OTHER inversion 18451855
nsv961252 CNV duplication 23825009

Variation tolerance for ZNF587 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.74; 73.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF587 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF587

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF587 Gene

Disorders for ZNF587 Gene

No disorders were found for ZNF587 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF587 Gene

Publications for ZNF587 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Computer sequence analysis of human highly conserved zinc finger modules. (PMID: 10520746) Petroni D … Comi P (DNA sequence : the journal of DNA sequencing and mapping 1998) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3

Products for ZNF587 Gene

Sources for ZNF587 Gene