Aliases for ZNF586 Gene

Aliases for ZNF586 Gene

  • Zinc Finger Protein 586 2 3 4 5
  • FLJ20070 2
  • ZNF586 5

External Ids for ZNF586 Gene

Previous GeneCards Identifiers for ZNF586 Gene

  • GC19P062973
  • GC19P062974
  • GC19P058281
  • GC19P054592

Summaries for ZNF586 Gene

GeneCards Summary for ZNF586 Gene

ZNF586 (Zinc Finger Protein 586) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF551.

UniProtKB/Swiss-Prot Summary for ZNF586 Gene

Additional gene information for ZNF586 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF586 Gene

Genomics for ZNF586 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF586 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF586 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF586

Top Transcription factor binding sites by QIAGEN in the ZNF586 gene promoter:
  • HTF

Genomic Locations for ZNF586 Gene

Genomic Locations for ZNF586 Gene
chr19:57,769,652-57,819,939
(GRCh38/hg38)
Size:
50,288 bases
Orientation:
Plus strand
chr19:58,281,020-58,331,307
(GRCh37/hg19)
Size:
50,288 bases
Orientation:
Plus strand

Genomic View for ZNF586 Gene

Genes around ZNF586 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF586 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF586 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF586 Gene

Proteins for ZNF586 Gene

  • Protein details for ZNF586 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXT0-ZN586_HUMAN
    Recommended name:
    Zinc finger protein 586
    Protein Accession:
    Q9NXT0
    Secondary Accessions:
    • A0JLV8
    • A8MY63
    • B3KTS9
    • E7ERT1
    • G3XAH3

    Protein attributes for ZNF586 Gene

    Size:
    402 amino acids
    Molecular mass:
    46413 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90930.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF586 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF586 Gene

Post-translational modifications for ZNF586 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF586 Gene

Domains & Families for ZNF586 Gene

Gene Families for ZNF586 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF586 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF586 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 586 (A0JLV8_HUMAN)
  • ZNF586 protein (Q8N6X9_HUMAN)
  • Zinc finger protein 586 (ZN586_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NXT0

UniProtKB/Swiss-Prot:

ZN586_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF586: view

Function for ZNF586 Gene

Molecular function for ZNF586 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF586 Gene

Gene Ontology (GO) - Molecular Function for ZNF586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF586: view
genes like me logo Genes that share phenotypes with ZNF586: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF586

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF586 Gene

Localization for ZNF586 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF586 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF586 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF586: view

Pathways & Interactions for ZNF586 Gene

PathCards logo

SuperPathways for ZNF586 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF586: view

Pathways by source for ZNF586 Gene

2 Reactome pathways for ZNF586 Gene

Gene Ontology (GO) - Biological Process for ZNF586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF586: view

No data available for SIGNOR curated interactions for ZNF586 Gene

Drugs & Compounds for ZNF586 Gene

No Compound Related Data Available

Transcripts for ZNF586 Gene

mRNA/cDNA for ZNF586 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF586

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF586 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2: -
SP3: -
SP4: - -

Relevant External Links for ZNF586 Gene

GeneLoc Exon Structure for
ZNF586

Expression for ZNF586 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF586 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF586 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for ZNF586 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF586 Gene



Protein tissue co-expression partners for ZNF586 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF586

SOURCE GeneReport for Unigene cluster for ZNF586 Gene:

Hs.625133

Evidence on tissue expression from TISSUES for ZNF586 Gene

  • Intestine(4.3)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with ZNF586: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF586 Gene

Orthologs for ZNF586 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF586 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF586 30 31
  • 99.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 42 (a)
OneToMany
Species where no ortholog for ZNF586 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF586 Gene

ENSEMBL:
Gene Tree for ZNF586 (if available)
TreeFam:
Gene Tree for ZNF586 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF586: view image

Paralogs for ZNF586 Gene

(527) SIMAP similar genes for ZNF586 Gene using alignment to 5 proteins:

  • ZN586_HUMAN
  • M0QZ99_HUMAN
  • M0R166_HUMAN
  • M0R336_HUMAN
  • Q8N6X9_HUMAN
genes like me logo Genes that share paralogs with ZNF586: view

Variants for ZNF586 Gene

Additional dbSNP identifiers (rs#s) for ZNF586 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF586 Gene

Variant ID Type Subtype PubMed ID
dgv3686n100 CNV gain 25217958
esv2670311 CNV deletion 23128226
esv2719091 CNV deletion 23290073
esv3644910 CNV loss 21293372
esv7167 CNV loss 19470904
nsv1066059 CNV gain 25217958
nsv520155 CNV loss 19592680

Variation tolerance for ZNF586 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF586 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF586

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF586 Gene

Disorders for ZNF586 Gene

No disorders were found for ZNF586 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF586 Gene

Publications for ZNF586 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF586 Gene

Sources for ZNF586 Gene