Aliases for ZNF585B Gene

Aliases for ZNF585B Gene

  • Zinc Finger Protein 585B 2 3 4 5
  • Zinc Finger Protein 41-Like Protein 3 4
  • SZFP41 3

External Ids for ZNF585B Gene

Previous GeneCards Identifiers for ZNF585B Gene

  • GC19M042335
  • GC19M042367
  • GC19M037675
  • GC19M034141
  • GC19M037677
  • GC19M037197
  • GC19M039013
  • GC19M039153
  • GC19M037232
  • GC19M037403
  • GC19M037430
  • GC19M037758
  • GC19M038058
  • GC19M038346
  • GC19M038641
  • GC19M038884

Summaries for ZNF585B Gene

GeneCards Summary for ZNF585B Gene

ZNF585B (Zinc Finger Protein 585B) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF585A.

UniProtKB/Swiss-Prot Summary for ZNF585B Gene

Additional gene information for ZNF585B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF585B Gene

Genomics for ZNF585B Gene

GeneHancer (GH) Regulatory Elements for ZNF585B Gene

Promoters and enhancers for ZNF585B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF585B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF585B gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • HOXA5
  • MRF-2
  • Pax-3

Genomic Locations for ZNF585B Gene

Genomic Locations for ZNF585B Gene
36,575 bases
Minus strand
36,575 bases
Minus strand

Genomic View for ZNF585B Gene

Genes around ZNF585B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF585B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF585B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF585B Gene

Proteins for ZNF585B Gene

  • Protein details for ZNF585B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 585B
    Protein Accession:
    Secondary Accessions:
    • Q8IZD3
    • Q96JW6

    Protein attributes for ZNF585B Gene

    769 amino acids
    Molecular mass:
    88066 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB55400.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF585B Gene

Post-translational modifications for ZNF585B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF585B Gene

Domains & Families for ZNF585B Gene

Gene Families for ZNF585B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF585B Gene

Suggested Antigen Peptide Sequences for ZNF585B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ34267 fis, clone FEBRA2002707, highly similar to Zinc finger protein 585B (B3KRH5_HUMAN)
  • zinc finger protein 41-like protein (Z585B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF585B: view

Function for ZNF585B Gene

Molecular function for ZNF585B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF585B Gene

Gene Ontology (GO) - Molecular Function for ZNF585B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF585B: view

Phenotypes for ZNF585B Gene

genes like me logo Genes that share phenotypes with ZNF585B: view

Animal Model Products

CRISPR Products

miRNA for ZNF585B Gene

miRTarBase miRNAs that target ZNF585B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF585B Gene

Localization for ZNF585B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF585B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF585B gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF585B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF585B: view

Pathways & Interactions for ZNF585B Gene

genes like me logo Genes that share pathways with ZNF585B: view

Pathways by source for ZNF585B Gene

2 Reactome pathways for ZNF585B Gene
1 KEGG pathway for ZNF585B Gene

Gene Ontology (GO) - Biological Process for ZNF585B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF585B: view

No data available for SIGNOR curated interactions for ZNF585B Gene

Drugs & Compounds for ZNF585B Gene

No Compound Related Data Available

Transcripts for ZNF585B Gene

mRNA/cDNA for ZNF585B Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF585B Gene

No ASD Table

Relevant External Links for ZNF585B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF585B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF585B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF585B Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF585B Gene:


SOURCE GeneReport for Unigene cluster for ZNF585B Gene:


Evidence on tissue expression from TISSUES for ZNF585B Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF585B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF585B Gene

Orthologs for ZNF585B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF585B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF585B 33 32
  • 98.4 (n)
(Mus musculus)
Mammalia Zfp27 33
  • 70 (a)
(Monodelphis domestica)
Mammalia -- 33
  • 47 (a)
-- 33
  • 45 (a)
-- 33
  • 44 (a)
-- 33
  • 44 (a)
-- 33
  • 43 (a)
-- 33
  • 42 (a)
-- 33
  • 41 (a)
-- 33
  • 40 (a)
-- 33
  • 39 (a)
(Bos Taurus)
Mammalia -- 33
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 43 (a)
-- 33
  • 39 (a)
-- 33
  • 36 (a)
-- 33
  • 35 (a)
-- 33
  • 33 (a)
CSA.1668 33
  • 31 (a)
Species where no ortholog for ZNF585B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF585B Gene

Gene Tree for ZNF585B (if available)
Gene Tree for ZNF585B (if available)
Evolutionary constrained regions (ECRs) for ZNF585B: view image

Paralogs for ZNF585B Gene

Paralogs for ZNF585B Gene

(620) SIMAP similar genes for ZNF585B Gene using alignment to 9 proteins:

  • Z585B_HUMAN
  • E9PQ00_HUMAN
  • F2Z3L4_HUMAN
  • K7EL12_HUMAN
  • K7EP93_HUMAN
  • K7EPG8_HUMAN Pseudogenes for ZNF585B Gene

genes like me logo Genes that share paralogs with ZNF585B: view

Variants for ZNF585B Gene

Sequence variations from dbSNP and Humsavar for ZNF585B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000047061 -- 37,195,425(-) C/T intron_variant
rs1000340447 -- 37,183,438(-) G/A 3_prime_UTR_variant
rs1000450952 -- 37,190,488(-) G/C intron_variant
rs1000470024 -- 37,190,785(-) C/T intron_variant
rs1000501323 -- 37,190,571(-) T/C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF585B Gene

Variant ID Type Subtype PubMed ID
esv3644280 CNV loss 21293372
esv3644282 CNV loss 21293372
esv3644283 CNV loss 21293372
nsv1064851 CNV loss 25217958
nsv579461 CNV gain 21841781

Variation tolerance for ZNF585B Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.10; 84.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF585B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF585B Gene

Disorders for ZNF585B Gene

Additional Disease Information for ZNF585B

No disorders were found for ZNF585B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF585B Gene

Publications for ZNF585B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 56

Products for ZNF585B Gene

Sources for ZNF585B Gene