Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF585A Gene

Aliases for ZNF585A Gene

  • Zinc Finger Protein 585A 2 3 5

External Ids for ZNF585A Gene

Previous GeneCards Identifiers for ZNF585A Gene

  • GC19M042334
  • GC19M042337
  • GC19M042289
  • GC19M037597
  • GC19M034110
  • GC19M037109
  • GC19M037114
  • GC19M037325
  • GC19M037386
  • GC19M037423
  • GC19M037750
  • GC19M038051

Summaries for ZNF585A Gene

GeneCards Summary for ZNF585A Gene

ZNF585A (Zinc Finger Protein 585A) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF585B.

UniProtKB/Swiss-Prot for ZNF585A Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF585A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF585A Gene

Genomics for ZNF585A Gene

GeneHancer (GH) Regulatory Elements for ZNF585A Gene

Promoters and enhancers for ZNF585A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I037171 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 140 1.6 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B ZNF585A ZNF383 ZNF345 ZNF850 ZNF567 ZNF571 ZNF146 ZNF573 ZNF829 HKR1
GH19I037593 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 156.2 -422.0 -421960 2.2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF213 ZNF571 ZNF540 ZNF567 ZNF527 ZFP30 ZNF383 HKR1 ZNF345 ZNF585A ZNF607
GH19I037653 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 138.6 -482.6 -482559 3 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 ZFP30 ZNF527 ZNF567 ZNF383 ZNF345 ZNF571 ZNF790 HKR1 ZNF850 ZNF585A
GH19I037370 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 138.5 -198.3 -198299 1.9 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF213 ZNF527 ZNF567 ZNF383 ZNF345 ZFP30 ZNF571 HKR1 ZNF850 ZNF793 ZNF790
GH19I036915 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 115 +256.2 256246 2.2 PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF302 ZNF416 ZNF143 ZNF548 SP3 ZNF568 ZNF829 GC19M038851 ZNF527 ZNF567 ZNF345 ZNF383 ZFP30 ZNF571 ZNF850
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF585A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF585A gene promoter:

Genomic Locations for ZNF585A Gene

Genomic Locations for ZNF585A Gene
66,008 bases
Minus strand

Genomic View for ZNF585A Gene

Genes around ZNF585A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF585A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF585A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF585A Gene

Proteins for ZNF585A Gene

  • Protein details for ZNF585A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 585A
    Protein Accession:
    Secondary Accessions:
    • Q8TE95
    • Q96MV3

    Protein attributes for ZNF585A Gene

    769 amino acids
    Molecular mass:
    87974 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB85057.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF585A Gene


neXtProt entry for ZNF585A Gene

Post-translational modifications for ZNF585A Gene

No Post-translational modifications

Other Protein References for ZNF585A Gene

No data available for DME Specific Peptides for ZNF585A Gene

Domains & Families for ZNF585A Gene

Gene Families for ZNF585A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF585A Gene

Suggested Antigen Peptide Sequences for ZNF585A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF585A: view

Function for ZNF585A Gene

Molecular function for ZNF585A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF585A Gene

Gene Ontology (GO) - Molecular Function for ZNF585A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF585A: view
genes like me logo Genes that share phenotypes with ZNF585A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF585A Gene

Localization for ZNF585A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF585A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF585A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF585A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF585A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF585A Gene

Pathways & Interactions for ZNF585A Gene

SuperPathways for ZNF585A Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF585A: view

Pathways by source for ZNF585A Gene

2 Reactome pathways for ZNF585A Gene

Interacting Proteins for ZNF585A Gene

Gene Ontology (GO) - Biological Process for ZNF585A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF585A: view

No data available for SIGNOR curated interactions for ZNF585A Gene

Drugs & Compounds for ZNF585A Gene

No Compound Related Data Available

Transcripts for ZNF585A Gene

Unigene Clusters for ZNF585A Gene

Zinc finger protein 585A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF585A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - -
SP2: - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - -
SP8: - -

Relevant External Links for ZNF585A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF585A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF585A Gene

Protein differential expression in normal tissues from HIPED for ZNF585A Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF585A Gene

Protein tissue co-expression partners for ZNF585A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF585A Gene:


SOURCE GeneReport for Unigene cluster for ZNF585A Gene:


Evidence on tissue expression from TISSUES for ZNF585A Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with ZNF585A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF585A Gene

Orthologs for ZNF585A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF585A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF585A 33 34
  • 99.09 (n)
(Bos Taurus)
Mammalia ZNF585A 33
  • 89.03 (n)
ZNF484 34
  • 46 (a)
(Mus musculus)
Mammalia Zfp27 33 16 34
  • 81.1 (n)
(Rattus norvegicus)
Mammalia Zfp27 33
  • 79.52 (n)
(Canis familiaris)
Mammalia ZNF585A 33
  • 77.06 (n)
-- 34
  • 45 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 45 (a)
-- 34
  • 45 (a)
-- 34
  • 42 (a)
-- 34
  • 41 (a)
-- 34
  • 41 (a)
-- 34
  • 40 (a)
-- 34
  • 38 (a)
-- 34
  • 38 (a)
-- 34
  • 36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733764 33
  • 55.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
-- 34
  • 39 (a)
-- 34
  • 37 (a)
-- 34
  • 35 (a)
-- 34
  • 33 (a)
CSA.1668 34
  • 32 (a)
Species where no ortholog for ZNF585A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF585A Gene

Gene Tree for ZNF585A (if available)
Gene Tree for ZNF585A (if available)

Paralogs for ZNF585A Gene

(538) SIMAP similar genes for ZNF585A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF585A: view

Variants for ZNF585A Gene

Sequence variations from dbSNP and Humsavar for ZNF585A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000091038 -- 37,167,995(-) T/C intron_variant
rs1000223814 -- 37,155,470(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000274262 -- 37,151,329(-) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000512090 -- 37,150,397(-) GGGGG/GGGG 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000583601 -- 37,151,551(-) G/C/T 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF585A Gene

Variant ID Type Subtype PubMed ID
nsv828545 CNV loss 20364138
nsv579461 CNV gain 21841781
nsv2477 CNV deletion 18451855
nsv1064851 CNV loss 25217958
esv3893201 CNV gain 25118596

Variation tolerance for ZNF585A Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.86; 67.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF585A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF585A Gene

Disorders for ZNF585A Gene

Additional Disease Information for ZNF585A

No disorders were found for ZNF585A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF585A Gene

Publications for ZNF585A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa RS … Obuse C (Nature cell biology 2010) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF585A Gene

Sources for ZNF585A Gene

Loading form....