Aliases for ZNF584 Gene

Aliases for ZNF584 Gene

  • Zinc Finger Protein 584 2 3 4 5
  • FLJ39899 2
  • ZNF584 5

External Ids for ZNF584 Gene

Previous GeneCards Identifiers for ZNF584 Gene

  • GC19P063612
  • GC19P063613
  • GC19P059046
  • GC19P059056
  • GC19P055229
  • GC19P059078
  • GC19P059096
  • GC19P059108
  • GC19P059150
  • GC19P059206
  • GC19P059248
  • GC19P059298
  • GC19P058402
  • GC19P058415
  • GC19P058421
  • GC19P058413
  • GC19P058411
  • GC19P058403
  • GC19P058405

Summaries for ZNF584 Gene

GeneCards Summary for ZNF584 Gene

ZNF584 (Zinc Finger Protein 584) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF792.

UniProtKB/Swiss-Prot Summary for ZNF584 Gene

Additional gene information for ZNF584 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF584 Gene

Genomics for ZNF584 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF584 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF584 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF584

Top Transcription factor binding sites by QIAGEN in the ZNF584 gene promoter:
  • AhR
  • AREB6
  • Arnt
  • CUTL1
  • E47
  • SEF-1 (1)
  • Spz1
  • SRF (504 AA)
  • ZID

Genomic Locations for ZNF584 Gene

Genomic Locations for ZNF584 Gene
chr19:58,401,472-58,431,396
(GRCh38/hg38)
Size:
29,925 bases
Orientation:
Plus strand
chr19:58,912,871-58,929,694
(GRCh37/hg19)
Size:
16,824 bases
Orientation:
Plus strand

Genomic View for ZNF584 Gene

Genes around ZNF584 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF584 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF584 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF584 Gene

Proteins for ZNF584 Gene

  • Protein details for ZNF584 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVC4-ZN584_HUMAN
    Recommended name:
    Zinc finger protein 584
    Protein Accession:
    Q8IVC4
    Secondary Accessions:
    • A8K203

    Protein attributes for ZNF584 Gene

    Size:
    421 amino acids
    Molecular mass:
    48272 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF584 Gene

Post-translational modifications for ZNF584 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF584 Gene

Domains & Families for ZNF584 Gene

Gene Families for ZNF584 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for ZNF584 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF584 Gene

GenScript: Design optimal peptide antigens:
  • ZNF584 protein (Q8WVQ2_HUMAN)
  • Zinc finger protein 584 (ZN584_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IVC4

UniProtKB/Swiss-Prot:

ZN584_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF584: view

Function for ZNF584 Gene

Molecular function for ZNF584 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF584 Gene

Gene Ontology (GO) - Molecular Function for ZNF584 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF584: view
genes like me logo Genes that share phenotypes with ZNF584: view

Animal Model Products

CRISPR Products

miRNA for ZNF584 Gene

miRTarBase miRNAs that target ZNF584

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF584

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF584 Gene

Localization for ZNF584 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF584 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF584 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF584 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF584: view

Pathways & Interactions for ZNF584 Gene

genes like me logo Genes that share pathways with ZNF584: view

Pathways by source for ZNF584 Gene

2 Reactome pathways for ZNF584 Gene
1 KEGG pathway for ZNF584 Gene

Interacting Proteins for ZNF584 Gene

Gene Ontology (GO) - Biological Process for ZNF584 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF584: view

No data available for SIGNOR curated interactions for ZNF584 Gene

Drugs & Compounds for ZNF584 Gene

No Compound Related Data Available

Transcripts for ZNF584 Gene

mRNA/cDNA for ZNF584 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF584

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF584 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12a ·
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - -
SP7: - - -
SP8: -
SP9: - -
SP10:
SP11: - - -

ExUns: 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ZNF584 Gene

GeneLoc Exon Structure for
ZNF584

Expression for ZNF584 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF584 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF584

SOURCE GeneReport for Unigene cluster for ZNF584 Gene:

Hs.439551

Evidence on tissue expression from TISSUES for ZNF584 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZNF584: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF584 Gene

Orthologs for ZNF584 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF584 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF584 30 31
  • 99.45 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF584 30 31
  • 83.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF584 30 31
  • 68.61 (n)
OneToOne
Species where no ortholog for ZNF584 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF584 Gene

ENSEMBL:
Gene Tree for ZNF584 (if available)
TreeFam:
Gene Tree for ZNF584 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF584: view image

Paralogs for ZNF584 Gene

(512) SIMAP similar genes for ZNF584 Gene using alignment to 7 proteins:

  • ZN584_HUMAN
  • F6W0P0_HUMAN
  • M0QZA3_HUMAN
  • M0R0A3_HUMAN
  • M0R2W6_HUMAN
  • M0R3F5_HUMAN
  • Q8WVQ2_HUMAN

Pseudogenes.org Pseudogenes for ZNF584 Gene

genes like me logo Genes that share paralogs with ZNF584: view

Variants for ZNF584 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF584 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs11668789 - p.Pro142Ser
rs7257872 - p.Thr301Ala

Additional dbSNP identifiers (rs#s) for ZNF584 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF584 Gene

Variant ID Type Subtype PubMed ID
esv1059195 CNV deletion 17803354
esv2546940 CNV deletion 19546169
nsv1057077 CNV gain 25217958
nsv515731 CNV gain+loss 19592680
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897
nsv954672 CNV deletion 24416366

Variation tolerance for ZNF584 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.54; 88.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF584 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF584

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF584 Gene

Disorders for ZNF584 Gene

No disorders were found for ZNF584 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF584 Gene

Publications for ZNF584 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Methylomics of breast cancer: Seeking epimarkers in peripheral blood of young subjects. (PMID: 28349825) Khakpour G … Tavakkoly-Bazzaz J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T … Hayashizaki Y (Cell 2010) 3
  5. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J … Elledge SJ (Cell 2009) 3

Products for ZNF584 Gene

Sources for ZNF584 Gene