The protein encoded by this gene is a zing finger protein and putative transcription factor that is highly methylated in cervical cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] See more...

Aliases for ZNF582 Gene

Aliases for ZNF582 Gene

  • Zinc Finger Protein 582 2 3 4 5

External Ids for ZNF582 Gene

Previous GeneCards Identifiers for ZNF582 Gene

  • GC19M061588
  • GC19M061589
  • GC19M056894
  • GC19M053203
  • GC19M056887

Summaries for ZNF582 Gene

Entrez Gene Summary for ZNF582 Gene

  • The protein encoded by this gene is a zing finger protein and putative transcription factor that is highly methylated in cervical cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for ZNF582 Gene

ZNF582 (Zinc Finger Protein 582) is a Protein Coding gene. Diseases associated with ZNF582 include Cervical Adenocarcinoma. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF566.

UniProtKB/Swiss-Prot Summary for ZNF582 Gene

Additional gene information for ZNF582 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF582 Gene

Genomics for ZNF582 Gene

GeneHancer (GH) Regulatory Elements for ZNF582 Gene

Promoters and enhancers for ZNF582 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF582 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF582

Top Transcription factor binding sites by QIAGEN in the ZNF582 gene promoter:
  • CUTL1
  • NCX
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • SREBP-1a
  • STAT1
  • USF-1
  • USF1
  • YY1

Genomic Locations for ZNF582 Gene

Genomic Locations for ZNF582 Gene
chr19:56,374,832-56,393,585
(GRCh38/hg38)
Size:
18,754 bases
Orientation:
Minus strand
chr19:56,887,413-56,904,914
(GRCh37/hg19)
Size:
17,502 bases
Orientation:
Minus strand

Genomic View for ZNF582 Gene

Genes around ZNF582 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF582 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF582 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF582 Gene

Proteins for ZNF582 Gene

  • Protein details for ZNF582 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NG8-ZN582_HUMAN
    Recommended name:
    Zinc finger protein 582
    Protein Accession:
    Q96NG8
    Secondary Accessions:
    • B4DQZ9
    • B7Z9R3
    • Q6PJT6

    Protein attributes for ZNF582 Gene

    Size:
    517 amino acids
    Molecular mass:
    60498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH11796.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAG61111.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAH14399.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=EAW72447.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF582 Gene

Post-translational modifications for ZNF582 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF582 Gene

Domains & Families for ZNF582 Gene

Gene Families for ZNF582 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF582 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF582 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56135, highly similar to Zinc finger protein 582 (B4DQZ9_HUMAN)
  • Zinc finger protein 582 (ZN582_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96NG8

UniProtKB/Swiss-Prot:

ZN582_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF582: view

Function for ZNF582 Gene

Molecular function for ZNF582 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF582 Gene

Gene Ontology (GO) - Molecular Function for ZNF582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF582: view
genes like me logo Genes that share phenotypes with ZNF582: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF582 Gene

Localization for ZNF582 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF582 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF582 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF582: view

Pathways & Interactions for ZNF582 Gene

genes like me logo Genes that share pathways with ZNF582: view

Pathways by source for ZNF582 Gene

2 Reactome pathways for ZNF582 Gene
1 KEGG pathway for ZNF582 Gene

Interacting Proteins for ZNF582 Gene

;

Gene Ontology (GO) - Biological Process for ZNF582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF582: view

No data available for SIGNOR curated interactions for ZNF582 Gene

Drugs & Compounds for ZNF582 Gene

No Compound Related Data Available

Transcripts for ZNF582 Gene

mRNA/cDNA for ZNF582 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF582 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2:
SP3: -

Relevant External Links for ZNF582 Gene

GeneLoc Exon Structure for
ZNF582

Expression for ZNF582 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF582 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF582

SOURCE GeneReport for Unigene cluster for ZNF582 Gene:

Hs.244391

Evidence on tissue expression from TISSUES for ZNF582 Gene

  • Nervous system(4.3)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with ZNF582: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF582 Gene

Orthologs for ZNF582 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF582 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF582 31 30
  • 99.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF582 30
  • 89.23 (n)
dog
(Canis familiaris)
Mammalia ZNF582 31
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6654 31
  • 21 (a)
OneToMany
Species where no ortholog for ZNF582 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF582 Gene

ENSEMBL:
Gene Tree for ZNF582 (if available)
TreeFam:
Gene Tree for ZNF582 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF582: view image

Paralogs for ZNF582 Gene

(485) SIMAP similar genes for ZNF582 Gene using alignment to 3 proteins:

  • ZN582_HUMAN
  • K7EKI7_HUMAN
  • K7ESE7_HUMAN
genes like me logo Genes that share paralogs with ZNF582: view

Variants for ZNF582 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF582 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs149022328 Uncertain Significance: not provided. - 56,384,383(-) C/Tp.Gly345Glu MISSENSE_VARIANT
rs369155373 Uncertain Significance: not provided. - 56,390,040(-) A/Cp.Trp65Gly MISSENSE_VARIANT
rs11883260 - p.Arg69Thr

Additional dbSNP identifiers (rs#s) for ZNF582 Gene

Variation tolerance for ZNF582 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF582 Gene

Human Gene Mutation Database (HGMD)
ZNF582
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF582

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF582 Gene

Disorders for ZNF582 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF582 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cervical adenocarcinoma
  • adenocarcinoma cervix uteri
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF582

genes like me logo Genes that share disorders with ZNF582: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF582 Gene

Publications for ZNF582 Gene

  1. Methylomic analysis identifies frequent DNA methylation of zinc finger protein 582 (ZNF582) in cervical neoplasms. (PMID: 22815913) Huang RL … Lai HC (PloS one 2012) 2 3 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. ZNF582 methylation as a potential biomarker to predict cervical intraepithelial neoplasia type III/worse: A meta-analysis of related studies in Chinese population. (PMID: 30732145) Li N … Hu Y (Medicine 2019) 3 54
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 54

Products for ZNF582 Gene

Sources for ZNF582 Gene