Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF581 Gene

Aliases for ZNF581 Gene

  • Zinc Finger Protein 581 2 3 5
  • HSPC189 3

External Ids for ZNF581 Gene

Previous GeneCards Identifiers for ZNF581 Gene

  • GC19P060847
  • GC19P060849
  • GC19P056154
  • GC19P052465

Summaries for ZNF581 Gene

GeneCards Summary for ZNF581 Gene

ZNF581 (Zinc Finger Protein 581) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF524.

UniProtKB/Swiss-Prot for ZNF581 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF581 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF581 Gene

Genomics for ZNF581 Gene

GeneHancer (GH) Regulatory Elements for ZNF581 Gene

Promoters and enhancers for ZNF581 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055639 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 575 +6.9 6902 6.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF580 ZNF581 CCDC106 U2AF2 ENSG00000267523 ENSG00000267096 ZNF628 ZNF582 KMT5C FIZ1
GH19I055633 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 550.8 +0.1 74 3.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF580 GC19P055633 ZNF581 CCDC106
GH19I055246 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 43.2 -381.6 -381600 14.5 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP6R1 LENG8 U2AF2 ZNF581 LENG8-AS1 ENSG00000235681 ENSG00000267523 BRSK1 HSPBP1 FIZ1
GH19I055519 Enhancer 1.4 FANTOM5 Ensembl ENCODE 52.8 -115.3 -115250 1 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 ZNF548 FOS ATF7 U2AF2 ZNF471 FIZ1 ZNF582 ZNF581 ZNF580 SSC5D ENSG00000267523 NAT14 ZNF667
GH19I055471 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.8 -160.3 -160301 6.4 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 ZNF628 ENSG00000269859 U2AF2 ENSG00000267523 ENSG00000267096 ZNF581 SSC5D NAT14 ZNF583 HSPBP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF581 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF581 gene promoter:

Genomic Locations for ZNF581 Gene

Genomic Locations for ZNF581 Gene
10,165 bases
Plus strand

Genomic View for ZNF581 Gene

Genes around ZNF581 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF581 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF581 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF581 Gene

Proteins for ZNF581 Gene

  • Protein details for ZNF581 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 581
    Protein Accession:
    Secondary Accessions:
    • B2RDM6

    Protein attributes for ZNF581 Gene

    197 amino acids
    Molecular mass:
    22010 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF581 Gene

Post-translational modifications for ZNF581 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF581 Gene

No data available for DME Specific Peptides for ZNF581 Gene

Domains & Families for ZNF581 Gene

Gene Families for ZNF581 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF581 Gene

Suggested Antigen Peptide Sequences for ZNF581 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF581: view

No data available for UniProtKB/Swiss-Prot for ZNF581 Gene

Function for ZNF581 Gene

Molecular function for ZNF581 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF581 Gene

Gene Ontology (GO) - Molecular Function for ZNF581 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF581: view
genes like me logo Genes that share phenotypes with ZNF581: view

Animal Model Products

CRISPR Products

miRNA for ZNF581 Gene

miRTarBase miRNAs that target ZNF581

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF581 Gene

Localization for ZNF581 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF581 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF581 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF581 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF581: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF581 Gene

Pathways & Interactions for ZNF581 Gene

SuperPathways for ZNF581 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF581 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF581: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF581 Gene

Drugs & Compounds for ZNF581 Gene

No Compound Related Data Available

Transcripts for ZNF581 Gene

Unigene Clusters for ZNF581 Gene

Zinc finger protein 581:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF581 Gene

No ASD Table

Relevant External Links for ZNF581 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF581 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF581 Gene

Protein differential expression in normal tissues from HIPED for ZNF581 Gene

This gene is overexpressed in CD8 Tcells (45.8) and Fetal ovary (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF581 Gene

Protein tissue co-expression partners for ZNF581 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF581 Gene:


SOURCE GeneReport for Unigene cluster for ZNF581 Gene:


Evidence on tissue expression from TISSUES for ZNF581 Gene

  • Blood(4.1)
  • Kidney(4.1)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with ZNF581: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF581 Gene

Orthologs for ZNF581 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF581 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF581 33 34
  • 97.59 (n)
(Canis familiaris)
Mammalia ZNF581 34
  • 88 (a)
(Bos Taurus)
Mammalia ZNF581 33 34
  • 85.96 (n)
(Monodelphis domestica)
Mammalia ZNF581 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 12 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 23 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730373 33
  • 60.56 (n)
(Danio rerio)
Actinopterygii ZNF581 34
  • 13 (a)
Species where no ortholog for ZNF581 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF581 Gene

Gene Tree for ZNF581 (if available)
Gene Tree for ZNF581 (if available)

Paralogs for ZNF581 Gene

Paralogs for ZNF581 Gene

(439) SIMAP similar genes for ZNF581 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF581: view

Variants for ZNF581 Gene

Sequence variations from dbSNP and Humsavar for ZNF581 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000077102 -- 55,636,294(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000112651 -- 55,641,738(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000309984 -- 55,638,962(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000340668 -- 55,644,460(+) C/T intron_variant
rs1000373375 -- 55,644,206(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF581 Gene

Variant ID Type Subtype PubMed ID
nsv2553 CNV insertion 18451855
nsv953625 CNV deletion 24416366

Variation tolerance for ZNF581 Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF581 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF581 Gene

Disorders for ZNF581 Gene

Additional Disease Information for ZNF581

No disorders were found for ZNF581 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF581 Gene

Publications for ZNF581 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZNF581 Gene

Sources for ZNF581 Gene

Loading form....