Aliases for ZNF580 Gene

Aliases for ZNF580 Gene

  • Zinc Finger Protein 580 2 3 4 5
  • LDL-Induced EC Protein 3 4
  • ZNF580 5

External Ids for ZNF580 Gene

Previous GeneCards Identifiers for ZNF580 Gene

  • GC19P060845
  • GC19P060848
  • GC19P056152
  • GC19P052462
  • GC19P055634

Summaries for ZNF580 Gene

GeneCards Summary for ZNF580 Gene

ZNF580 (Zinc Finger Protein 580) is a Protein Coding gene. An important paralog of this gene is ZNF581.

UniProtKB/Swiss-Prot Summary for ZNF580 Gene

  • Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.

Additional gene information for ZNF580 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF580 Gene

Genomics for ZNF580 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF580 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF580 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF580

Top Transcription factor binding sites by QIAGEN in the ZNF580 gene promoter:
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • ITF-2
  • PPAR-gamma2

Genomic Locations for ZNF580 Gene

Genomic Locations for ZNF580 Gene
chr19:55,635,016-55,643,470
(GRCh38/hg38)
Size:
8,455 bases
Orientation:
Plus strand
chr19:56,146,382-56,154,836
(GRCh37/hg19)
Size:
8,455 bases
Orientation:
Plus strand

Genomic View for ZNF580 Gene

Genes around ZNF580 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF580 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF580 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF580 Gene

Proteins for ZNF580 Gene

  • Protein details for ZNF580 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK33-ZN580_HUMAN
    Recommended name:
    Zinc finger protein 580
    Protein Accession:
    Q9UK33
    Secondary Accessions:
    • B2RC05
    • Q9NPP7

    Protein attributes for ZNF580 Gene

    Size:
    172 amino acids
    Molecular mass:
    18756 Da
    Quaternary structure:
    • Interacts with SMAD2.
    SequenceCaution:
    • Sequence=CAB94389.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZNF580 Gene

Post-translational modifications for ZNF580 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF580 Gene

No data available for DME Specific Peptides for ZNF580 Gene

Domains & Families for ZNF580 Gene

Gene Families for ZNF580 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF580 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF580 Gene

GenScript: Design optimal peptide antigens:
  • LDL-induced EC protein (ZN580_HUMAN)
genes like me logo Genes that share domains with ZNF580: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF580 Gene

Function for ZNF580 Gene

Molecular function for ZNF580 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in presence of reactive oxygen species (ROS), like H(2)O(2), through the NF-kappaB signaling pathway. Up-regulated by sphingosine-1-phosphate (SP1) through the p38 MAPK signaling pathway (at protein level).

Phenotypes From GWAS Catalog for ZNF580 Gene

Gene Ontology (GO) - Molecular Function for ZNF580 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21599657
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF580: view
genes like me logo Genes that share phenotypes with ZNF580: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF580

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF580 Gene

Localization for ZNF580 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF580 Gene

Nucleus. Note=Colocalized with SMAD2 in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF580 gene
Compartment Confidence
nucleus 5
extracellular 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF580 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA,IDA 20382120
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF580: view

Pathways & Interactions for ZNF580 Gene

PathCards logo

SuperPathways for ZNF580 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF580 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 20382120
GO:0002690 positive regulation of leukocyte chemotaxis IDA 21830064
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with ZNF580: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF580 Gene

Drugs & Compounds for ZNF580 Gene

No Compound Related Data Available

Transcripts for ZNF580 Gene

mRNA/cDNA for ZNF580 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF580

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF580 Gene

No ASD Table

Relevant External Links for ZNF580 Gene

GeneLoc Exon Structure for
ZNF580

Expression for ZNF580 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF580 Gene

Protein differential expression in normal tissues from HIPED for ZNF580 Gene

This gene is overexpressed in Fetal ovary (33.9), Fetal Brain (25.0), and Platelet (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF580 Gene



Protein tissue co-expression partners for ZNF580 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF580

SOURCE GeneReport for Unigene cluster for ZNF580 Gene:

Hs.631551

mRNA Expression by UniProt/SwissProt for ZNF580 Gene:

Q9UK33-ZN580_HUMAN
Tissue specificity: Expressed in endothelial cells.

Evidence on tissue expression from TISSUES for ZNF580 Gene

  • Heart(4.5)
genes like me logo Genes that share expression patterns with ZNF580: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF580 Gene

Orthologs for ZNF580 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF580 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF580 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF580 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF580 30 31
  • 91.67 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp580 30
  • 90.81 (n)
Mouse
(Mus musculus)
Mammalia Zfp580 30 17 31
  • 90.81 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF580 31
  • 67 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 10 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 13 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ZNF581 31
  • 10 (a)
OneToMany
Species where no ortholog for ZNF580 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF580 Gene

ENSEMBL:
Gene Tree for ZNF580 (if available)
TreeFam:
Gene Tree for ZNF580 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF580: view image

Paralogs for ZNF580 Gene

(30) SIMAP similar genes for ZNF580 Gene using alignment to 4 proteins:

  • ZN580_HUMAN
  • K7EJ53_HUMAN
  • K7ENY2_HUMAN
  • K7ERU0_HUMAN

Pseudogenes.org Pseudogenes for ZNF580 Gene

genes like me logo Genes that share paralogs with ZNF580: view

Variants for ZNF580 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF580 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
777510 Benign: not provided 55,642,752(+) C/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF580 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF580 Gene

Variant ID Type Subtype PubMed ID
nsv2553 CNV insertion 18451855
nsv828643 CNV loss 20364138
nsv953625 CNV deletion 24416366

Variation tolerance for ZNF580 Gene

Gene Damage Index Score: 2.73; 46.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF580 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF580

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF580 Gene

Disorders for ZNF580 Gene

Additional Disease Information for ZNF580

No disorders were found for ZNF580 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF580 Gene

Publications for ZNF580 Gene

  1. ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-β signal molecule Smad2. (PMID: 21599657) Luo Y … Zhang W (Cell biology international 2011) 2 3 4
  2. ROS-induced ZNF580 expression: a key role for H2O2/NF-κB signaling pathway in vascular endothelial inflammation. (PMID: 21830064) DangLi R … WenCheng Z (Molecular and cellular biochemistry 2012) 3 4
  3. Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis. (PMID: 20382120) Sun HY … Zhang WC (Biochemical and biophysical research communications 2010) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF580 Gene

  • Signalway Proteins for ZNF580

Sources for ZNF580 Gene