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Aliases for ZNF579 Gene

Aliases for ZNF579 Gene

  • Zinc Finger Protein 579 2 3 5

External Ids for ZNF579 Gene

Previous GeneCards Identifiers for ZNF579 Gene

  • GC19M060781
  • GC19M060782
  • GC19M056088
  • GC19M052399

Summaries for ZNF579 Gene

GeneCards Summary for ZNF579 Gene

ZNF579 (Zinc Finger Protein 579) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZNF579 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF579 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF579 Gene

Genomics for ZNF579 Gene

GeneHancer (GH) Regulatory Elements for ZNF579 Gene

Promoters and enhancers for ZNF579 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055579 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 557.8 -0.3 -301 3.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF579 FIZ1 ZNF471 ZNF582 ZNF542P ZNF470 ENSG00000269696 ZFP28 ZNF583 ZNF582-AS1
GH19I055246 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.2 +327.0 327040 14.5 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP6R1 LENG8 U2AF2 ZNF581 LENG8-AS1 ENSG00000235681 ENSG00000267523 BRSK1 HSPBP1 FIZ1
GH19I055215 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 10.2 +364.2 364194 2.9 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ENSG00000267649 LENG8-AS1 U2AF2 LENG8 ENSG00000235681 ENSG00000267523 SSC5D ZNF580 ENSG00000267096 ZNF581
GH19I055584 Enhancer 1.2 Ensembl ENCODE 7.3 -5.6 -5623 3.1 PKNOX1 ATF1 ARID4B SIN3A BRCA1 YY1 ZNF121 GLIS2 ZNF213 ATF7 ZNF628 U2AF2 ENSG00000267523 ZNF581 ENSG00000267096 ZNF579 ZNF580 ZNF524
GH19I055368 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 1.4 +210.9 210909 2.9 PKNOX1 SIN3A GLI4 ZNF48 ZNF121 GLIS2 SP3 NFYC REST SMARCB1 IL11 TMEM190 RPL28 COX6B2 NAT14 ZNF579 FAM71E2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF579 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF579 gene promoter:

Genomic Locations for ZNF579 Gene

Genomic Locations for ZNF579 Gene
chr19:55,576,770-55,580,899
(GRCh38/hg38)
Size:
4,130 bases
Orientation:
Minus strand
chr19:56,088,891-56,092,211
(GRCh37/hg19)

Genomic View for ZNF579 Gene

Genes around ZNF579 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF579 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF579 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF579 Gene

Proteins for ZNF579 Gene

  • Protein details for ZNF579 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAF0-ZN579_HUMAN
    Recommended name:
    Zinc finger protein 579
    Protein Accession:
    Q8NAF0

    Protein attributes for ZNF579 Gene

    Size:
    562 amino acids
    Molecular mass:
    60509 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF579 Gene

Post-translational modifications for ZNF579 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF579 Gene

No data available for DME Specific Peptides for ZNF579 Gene

Domains & Families for ZNF579 Gene

Gene Families for ZNF579 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF579 Gene

Suggested Antigen Peptide Sequences for ZNF579 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NAF0

UniProtKB/Swiss-Prot:

ZN579_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF579: view

Function for ZNF579 Gene

Molecular function for ZNF579 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF579 Gene

Gene Ontology (GO) - Molecular Function for ZNF579 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA,IDA 22681889
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF579: view
genes like me logo Genes that share phenotypes with ZNF579: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF579 Gene

Localization for ZNF579 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF579 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF579 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF579 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF579: view

Pathways & Interactions for ZNF579 Gene

SuperPathways for ZNF579 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF579 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF579: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF579 Gene

Drugs & Compounds for ZNF579 Gene

No Compound Related Data Available

Transcripts for ZNF579 Gene

mRNA/cDNA for ZNF579 Gene

Unigene Clusters for ZNF579 Gene

Zinc finger protein 579:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF579 Gene

No ASD Table

Relevant External Links for ZNF579 Gene

GeneLoc Exon Structure for
ZNF579
ECgene alternative splicing isoforms for
ZNF579

Expression for ZNF579 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF579 Gene

Protein differential expression in normal tissues from HIPED for ZNF579 Gene

This gene is overexpressed in Bone marrow stromal cell (20.9), Fetal Brain (17.9), and Adrenal (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF579 Gene



Protein tissue co-expression partners for ZNF579 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF579 Gene:

ZNF579

SOURCE GeneReport for Unigene cluster for ZNF579 Gene:

Hs.112529

Evidence on tissue expression from TISSUES for ZNF579 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ZNF579: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF579 Gene

Orthologs for ZNF579 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF579 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF579 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia ZNF579 33 34
  • 85.4 (n)
cow
(Bos Taurus)
Mammalia ZNF579 33
  • 83.76 (n)
mouse
(Mus musculus)
Mammalia Zfp579 33 16 34
  • 80.87 (n)
rat
(Rattus norvegicus)
Mammalia Zfp579 33
  • 80.61 (n)
Species where no ortholog for ZNF579 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF579 Gene

ENSEMBL:
Gene Tree for ZNF579 (if available)
TreeFam:
Gene Tree for ZNF579 (if available)

Paralogs for ZNF579 Gene

(11) SIMAP similar genes for ZNF579 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF579: view

No data available for Paralogs for ZNF579 Gene

Variants for ZNF579 Gene

Sequence variations from dbSNP and Humsavar for ZNF579 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000081718 -- 55,577,817(-) G/T 3_prime_UTR_variant, intron_variant
rs1000979222 -- 55,577,820(-) C/A 3_prime_UTR_variant, intron_variant
rs1001259065 -- 55,577,074(-) C/G/T downstream_transcript_variant
rs1001607024 -- 55,577,296(-) A/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1002330322 -- 55,579,186(-) C/G/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF579 Gene

Variant ID Type Subtype PubMed ID
nsv828643 CNV loss 20364138
nsv953624 CNV deletion 24416366

Variation tolerance for ZNF579 Gene

Gene Damage Index Score: 2.60; 45.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF579 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF579

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF579 Gene

Disorders for ZNF579 Gene

Additional Disease Information for ZNF579

No disorders were found for ZNF579 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF579 Gene

Publications for ZNF579 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner BA … Cristea IM (Molecular & cellular proteomics : MCP 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ZNF579 Gene

Sources for ZNF579 Gene

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