Aliases for ZNF578 Gene

Aliases for ZNF578 Gene

  • Zinc Finger Protein 578 2 3 4 5
  • FLJ31384 2
  • ZNF578 5

External Ids for ZNF578 Gene

Previous GeneCards Identifiers for ZNF578 Gene

  • GC19P057124
  • GC19P057709
  • GC19P057580
  • GC19P057649
  • GC19P052959
  • GC19P049287

Summaries for ZNF578 Gene

GeneCards Summary for ZNF578 Gene

ZNF578 (Zinc Finger Protein 578) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF813.

UniProtKB/Swiss-Prot Summary for ZNF578 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF578 Gene

Genomics for ZNF578 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF578 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF578 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF578

Top Transcription factor binding sites by QIAGEN in the ZNF578 gene promoter:
  • GATA-1
  • Ik-1

Genomic Locations for ZNF578 Gene

Latest Assembly
chr19:52,453,553-52,516,882
(GRCh38/hg38)
Size:
63,330 bases
Orientation:
Plus strand

Previous Assembly
chr19:52,956,806-53,020,135
(GRCh37/hg19 by Entrez Gene)
Size:
63,330 bases
Orientation:
Plus strand

chr19:52,956,829-53,015,407
(GRCh37/hg19 by Ensembl)
Size:
58,579 bases
Orientation:
Plus strand

Genomic View for ZNF578 Gene

Genes around ZNF578 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF578 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF578 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF578 Gene

Proteins for ZNF578 Gene

  • Protein details for ZNF578 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N58-ZN578_HUMAN
    Recommended name:
    Zinc finger protein 578
    Protein Accession:
    Q96N58
    Secondary Accessions:
    • B4DR51
    • I3L1Y6

    Protein attributes for ZNF578 Gene

    Size:
    590 amino acids
    Molecular mass:
    68531 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71051.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZNF578 Gene

Post-translational modifications for ZNF578 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF578 Gene

No data available for DME Specific Peptides for ZNF578 Gene

Domains & Families for ZNF578 Gene

Gene Families for ZNF578 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF578 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • Type I EGF
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF578 Gene

GenScript: Design optimal peptide antigens:
  • ZNF578 protein (Q3MI94_HUMAN)
  • Zinc finger protein 578 (ZN578_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96N58

UniProtKB/Swiss-Prot:

ZN578_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF578: view

Function for ZNF578 Gene

Molecular function for ZNF578 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF578 Gene

Gene Ontology (GO) - Molecular Function for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with ZNF578: view
genes like me logo Genes that share phenotypes with ZNF578: view

miRNA for ZNF578 Gene

miRTarBase miRNAs that target ZNF578

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF578

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF578 Gene

Localization for ZNF578 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF578 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF578 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF578: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF578 Gene

Pathways & Interactions for ZNF578 Gene

PathCards logo

SuperPathways for ZNF578 Gene

genes like me logo Genes that share pathways with ZNF578: view

Pathways by source for ZNF578 Gene

1 KEGG pathway for ZNF578 Gene

Gene Ontology (GO) - Biological Process for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF578: view

No data available for SIGNOR curated interactions for ZNF578 Gene

Drugs & Compounds for ZNF578 Gene

No Compound Related Data Available

Transcripts for ZNF578 Gene

mRNA/cDNA for ZNF578 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF578

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF578 Gene

No ASD Table

Relevant External Links for ZNF578 Gene

GeneLoc Exon Structure for
ZNF578

Expression for ZNF578 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF578 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF578 Gene

This gene is overexpressed in Testis (x7.8).

Protein differential expression in normal tissues from HIPED for ZNF578 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF578 Gene



Protein tissue co-expression partners for ZNF578 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF578

SOURCE GeneReport for Unigene cluster for ZNF578 Gene:

Hs.157287
genes like me logo Genes that share expression patterns with ZNF578: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF578 Gene

Orthologs for ZNF578 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF578 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 73 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 53 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 42 (a)
ManyToMany
Species where no ortholog for ZNF578 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF578 Gene

ENSEMBL:
Gene Tree for ZNF578 (if available)
TreeFam:
Gene Tree for ZNF578 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF578: view image

Paralogs for ZNF578 Gene

(523) SIMAP similar genes for ZNF578 Gene using alignment to 3 proteins:

  • ZN578_HUMAN
  • M0QZV4_HUMAN
  • Q3MI94_HUMAN
genes like me logo Genes that share paralogs with ZNF578: view

Variants for ZNF578 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF578 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs161931 - p.Glu238Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF578 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF578 Gene

Variant ID Type Subtype PubMed ID
dgv3627n100 CNV gain 25217958
esv2718785 CNV deletion 23290073
esv2762048 CNV loss 21179565
esv3644693 CNV loss 21293372
esv3644696 CNV loss 21293372
esv3644697 CNV loss 21293372
esv3893233 CNV loss 25118596
nsv1058567 CNV gain 25217958
nsv1063648 CNV gain 25217958
nsv1114030 CNV deletion 24896259
nsv436854 CNV insertion 17901297
nsv509751 CNV insertion 20534489
nsv580026 CNV loss 21841781
nsv978841 CNV duplication 23825009

Variation tolerance for ZNF578 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF578 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF578

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF578 Gene

Disorders for ZNF578 Gene

Additional Disease Information for ZNF578

No disorders were found for ZNF578 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF578 Gene

Publications for ZNF578 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4

Products for ZNF578 Gene

Sources for ZNF578 Gene