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Aliases for ZNF578 Gene

Aliases for ZNF578 Gene

  • Zinc Finger Protein 578 2 3 5

External Ids for ZNF578 Gene

Previous GeneCards Identifiers for ZNF578 Gene

  • GC19P057124
  • GC19P057709
  • GC19P057580
  • GC19P057649
  • GC19P052959
  • GC19P049287

Summaries for ZNF578 Gene

GeneCards Summary for ZNF578 Gene

ZNF578 (Zinc Finger Protein 578) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF808.

UniProtKB/Swiss-Prot for ZNF578 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF578 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF578 Gene

Genomics for ZNF578 Gene

GeneHancer (GH) Regulatory Elements for ZNF578 Gene

Promoters and enhancers for ZNF578 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I052452 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 556.4 +0.2 168 1.5 SP3 NRF1 ELF1 ZBTB40 ZNF518A NR2F2 ETS1 GABPA CBX1 POLR2A ZNF578 GC19P052460 ZNF534 ENSG00000269001 LOC100419836
GH19I052484 Promoter/Enhancer 0.7 EPDnew ENCODE 550.3 +32.0 32014 2.6 ZNF578 ENSG00000269349 PIR42475 PIR51841
GH19I052137 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 23.1 -313.9 -313874 3.3 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF616 ZNF137P ZNF160 ZNF808 ENSG00000268970 ZNF600 ZNF350 ZNF816 ZNF836 ZNF577
GH19I051687 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 23.1 -763.0 -763015 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 ZNF137P ZNF808 ZNF841 ZNF616 ZNF766 ZNF577 ENSG00000268970 ZNF836 ENSG00000269825 ZNF175
GH19I052188 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.7 -263.2 -263188 4.4 HDGF PKNOX1 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 POLR2B PPP2R1A ZNF766 ZNF175 ENSG00000269483 ZNF614 ZNF415 ZNF528 ZNF578 ENSG00000268225 ZNF160
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF578 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF578 gene promoter:

Genomic Locations for ZNF578 Gene

Genomic Locations for ZNF578 Gene
63,373 bases
Plus strand

Genomic View for ZNF578 Gene

Genes around ZNF578 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF578 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF578 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF578 Gene

Proteins for ZNF578 Gene

  • Protein details for ZNF578 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 578
    Protein Accession:
    Secondary Accessions:
    • B4DR51
    • I3L1Y6

    Protein attributes for ZNF578 Gene

    590 amino acids
    Molecular mass:
    68531 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71051.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF578 Gene

Post-translational modifications for ZNF578 Gene

No Post-translational modifications

Other Protein References for ZNF578 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF578 Gene

Domains & Families for ZNF578 Gene

Gene Families for ZNF578 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF578 Gene

Suggested Antigen Peptide Sequences for ZNF578 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF578: view

Function for ZNF578 Gene

Molecular function for ZNF578 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF578 Gene

Gene Ontology (GO) - Molecular Function for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF578: view

Phenotypes for ZNF578 Gene

genes like me logo Genes that share phenotypes with ZNF578: view

miRNA for ZNF578 Gene

miRTarBase miRNAs that target ZNF578

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF578 Gene

Localization for ZNF578 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF578 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF578 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF578: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF578 Gene

Pathways & Interactions for ZNF578 Gene

SuperPathways for ZNF578 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF578 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF578: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF578 Gene

Drugs & Compounds for ZNF578 Gene

No Compound Related Data Available

Transcripts for ZNF578 Gene

Unigene Clusters for ZNF578 Gene

Zinc finger protein 578:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF578 Gene

No ASD Table

Relevant External Links for ZNF578 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF578 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF578 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF578 Gene

This gene is overexpressed in Testis (x7.8).

Protein differential expression in normal tissues from HIPED for ZNF578 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF578 Gene

Protein tissue co-expression partners for ZNF578 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF578 Gene:


SOURCE GeneReport for Unigene cluster for ZNF578 Gene:

genes like me logo Genes that share expression patterns with ZNF578: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF578 Gene

Orthologs for ZNF578 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF578 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 73 (a)
(Canis familiaris)
Mammalia -- 34
  • 53 (a)
(Bos Taurus)
Mammalia -- 34
  • 42 (a)
Species where no ortholog for ZNF578 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF578 Gene

Gene Tree for ZNF578 (if available)
Gene Tree for ZNF578 (if available)

Paralogs for ZNF578 Gene

(523) SIMAP similar genes for ZNF578 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF578: view

Variants for ZNF578 Gene

Sequence variations from dbSNP and Humsavar for ZNF578 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000002374 -- 52,480,238(+) T/G intron_variant
rs1000005141 -- 52,508,748(+) T/C intron_variant
rs1000063774 -- 52,466,795(+) A/G intron_variant
rs1000077397 -- 52,473,217(+) C/T intron_variant
rs1000094713 -- 52,472,065(+) T/A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF578 Gene

Variant ID Type Subtype PubMed ID
nsv978841 CNV duplication 23825009
nsv580026 CNV loss 21841781
nsv509751 CNV insertion 20534489
nsv436854 CNV insertion 17901297
nsv1114030 CNV deletion 24896259
nsv1063648 CNV gain 25217958
nsv1058567 CNV gain 25217958
esv3893233 CNV loss 25118596
esv3644697 CNV loss 21293372
esv3644696 CNV loss 21293372
esv3644693 CNV loss 21293372
esv2762048 CNV loss 21179565
esv2718785 CNV deletion 23290073
dgv3627n100 CNV gain 25217958

Variation tolerance for ZNF578 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF578 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF578 Gene

Disorders for ZNF578 Gene

Additional Disease Information for ZNF578

No disorders were found for ZNF578 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF578 Gene

Publications for ZNF578 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF578 Gene

Sources for ZNF578 Gene

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