Aliases for ZNF577 Gene

Aliases for ZNF577 Gene

  • Zinc Finger Protein 577 2 3 4 5

External Ids for ZNF577 Gene

Previous GeneCards Identifiers for ZNF577 Gene

  • GC19M057067
  • GC19M057069
  • GC19M052359
  • GC19M048689
  • GC19M051855

Summaries for ZNF577 Gene

GeneCards Summary for ZNF577 Gene

ZNF577 (Zinc Finger Protein 577) is a Protein Coding gene. Diseases associated with ZNF577 include Ichthyosis, Congenital, Autosomal Recessive 11 and Autosomal Recessive Congenital Ichthyosis. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF630.

UniProtKB/Swiss-Prot Summary for ZNF577 Gene

Additional gene information for ZNF577 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF577 Gene

Genomics for ZNF577 Gene

GeneHancer (GH) Regulatory Elements for ZNF577 Gene

Promoters and enhancers for ZNF577 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051903 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 517.1 -14.2 -14208 6.3 CTCF SIN3A POLR2G SIX5 ZBTB5 POLR2A ZBTB10 ZBTB11 AFF1 ZBTB26 ZNF577 ZNF649 piR-40154-091 piR-52261-135 ZNF350-AS1 ZNF350 ZNF615 FPR3 ZNF841 SIGLEC5
GH19J051887 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 523 +1.9 1949 4.4 EP300 MYC USF1 ZBTB10 ZBTB26 TRIM28 ZEB1 POLR2A ZNF274 HCFC1 ZNF577 lnc-ZNF649-3 ZNF613 FPR3 ZNF615 ZNF350 ZNF649 ZNF649-AS1
GH19J051896 Promoter 0.4 EPDnew 500.4 -6.0 -6003 0.1 POLR2A lnc-ZNF577-1 ZNF577 ZNF649 ZNF649-AS1
GH19J051687 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 53 +200.5 200459 6.9 EP300 CTCF TCF12 NCOR1 BCLAF1 RBAK GTF2E2 TEAD4 PHB2 ZFX SPACA6 ZNF808 ZNF137P ZNF766 ZNF175 ZNF577 ZNF841 ZNF616 ENSG00000269825 ENSG00000268970
GH19J051358 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 38.7 +527.1 527148 11.2 EP300 FOXK2 ZBTB40 CTCF NRF1 TCF12 POLR2G SP1 NCOR1 GTF2E2 ETFB ENSG00000268520 CLDND2 ZNF841 ZNF616 ZNF175 ZNF766 POLD1 ZNF577 ZNF836
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF577 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF577

Top Transcription factor binding sites by QIAGEN in the ZNF577 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Ik-1

Genomic Locations for ZNF577 Gene

Genomic Locations for ZNF577 Gene
86,135 bases
Minus strand
35,149 bases
Minus strand

Genomic View for ZNF577 Gene

Genes around ZNF577 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF577 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF577 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF577 Gene

Proteins for ZNF577 Gene

  • Protein details for ZNF577 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 577
    Protein Accession:
    Secondary Accessions:
    • A8K0B4
    • A8K6Z7
    • C9JFB9

    Protein attributes for ZNF577 Gene

    485 amino acids
    Molecular mass:
    54939 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH04992.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAF82168.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=EAW72049.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF577 Gene


neXtProt entry for ZNF577 Gene

Post-translational modifications for ZNF577 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF577 Gene

Domains & Families for ZNF577 Gene

Gene Families for ZNF577 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF577 Gene

  • C2H2-type zinc finger signature
  • KRAB box

Suggested Antigen Peptide Sequences for ZNF577 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 577 (ZN577_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF577: view

Function for ZNF577 Gene

Molecular function for ZNF577 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF577 Gene

Gene Ontology (GO) - Molecular Function for ZNF577 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF577: view
genes like me logo Genes that share phenotypes with ZNF577: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF577 Gene

Localization for ZNF577 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF577 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF577 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF577 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF577: view

Pathways & Interactions for ZNF577 Gene

genes like me logo Genes that share pathways with ZNF577: view

Pathways by source for ZNF577 Gene

2 Reactome pathways for ZNF577 Gene
1 KEGG pathway for ZNF577 Gene

Interacting Proteins for ZNF577 Gene


Gene Ontology (GO) - Biological Process for ZNF577 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF577: view

No data available for SIGNOR curated interactions for ZNF577 Gene

Drugs & Compounds for ZNF577 Gene

No Compound Related Data Available

Transcripts for ZNF577 Gene

mRNA/cDNA for ZNF577 Gene

14 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF577 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: - - - -
SP2: -
SP3: - -
SP4: -
SP5: - -
SP6: - - - - -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for ZNF577 Gene

GeneLoc Exon Structure for

Expression for ZNF577 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF577 Gene

Protein differential expression in normal tissues from HIPED for ZNF577 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF577 Gene

Protein tissue co-expression partners for ZNF577 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF577

SOURCE GeneReport for Unigene cluster for ZNF577 Gene:


Evidence on tissue expression from TISSUES for ZNF577 Gene

  • Nervous system(4.4)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZNF577: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF577 Gene

Orthologs for ZNF577 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF577 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF577 31 30
  • 98.9 (n)
(Canis familiaris)
Mammalia ZNF577 30
  • 85 (n)
-- 31
  • 68 (a)
-- 31
  • 31 (a)
(Bos Taurus)
Mammalia ZNF577 30
  • 76.95 (n)
Species where no ortholog for ZNF577 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF577 Gene

Gene Tree for ZNF577 (if available)
Gene Tree for ZNF577 (if available)
Evolutionary constrained regions (ECRs) for ZNF577: view image

Paralogs for ZNF577 Gene

Paralogs for ZNF577 Gene

(492) SIMAP similar genes for ZNF577 Gene using alignment to 7 proteins:

  • ZN577_HUMAN
  • C9JP99_HUMAN
  • C9JX31_HUMAN
genes like me logo Genes that share paralogs with ZNF577: view

Variants for ZNF577 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF577 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10407547 - p.Glu373Lys
rs10407911 - p.Thr375Ile
rs17849895 - p.Arg123Cys
rs17856123 - p.Ala84Val
rs2288868 - p.Lys246Glu

Additional dbSNP identifiers (rs#s) for ZNF577 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF577 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
esv3644680 CNV gain 21293372
esv3644682 CNV gain 21293372
nsv1063362 CNV gain 25217958
nsv1140251 OTHER inversion 24896259
nsv458733 CNV gain 19166990
nsv470151 CNV gain 18288195
nsv579997 CNV gain 21841781
nsv580001 CNV gain 21841781
nsv580005 CNV loss 21841781

Variation tolerance for ZNF577 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.64; 91.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF577 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF577 Gene

Disorders for ZNF577 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF577 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF577

genes like me logo Genes that share disorders with ZNF577: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF577 Gene

Publications for ZNF577 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  4. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J … Elledge SJ (Nature biotechnology 2013) 3 54
  5. Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility. (PMID: 21424380) Sehrawat B … Damaraju S (Human genetics 2011) 3 54

Products for ZNF577 Gene

Sources for ZNF577 Gene