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Aliases for ZNF576 Gene

Aliases for ZNF576 Gene

  • Zinc Finger Protein 576 2 3 5

External Ids for ZNF576 Gene

Previous GeneCards Identifiers for ZNF576 Gene

  • GC19P048793
  • GC19P048794
  • GC19P044100
  • GC19P040531

Summaries for ZNF576 Gene

GeneCards Summary for ZNF576 Gene

ZNF576 (Zinc Finger Protein 576) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA polymerase II transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZNF576 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF576 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF576 Gene

Genomics for ZNF576 Gene

GeneHancer (GH) Regulatory Elements for ZNF576 Gene

Promoters and enhancers for ZNF576 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I043594 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 572.3 +0.0 3 4.5 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 GLIS1 ZNF576 IRGQ SRRM5 ZNF45 ZNF180 ZNF112 ZNF283 ZNF224 ZNF225 MRPS15P2
GH19I043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 116.2 +183.5 183510 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF224 ZNF284 ZNF227 ZNF283 ZNF223 ZNF576
GH19I044111 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 92.3 +516.6 516609 2.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF225 LOC100379224 ZNF45 ZNF180 ZNF227 ZNF283 ZNF576 ZNF112 ZNF224 ZNF226
GH19I044259 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 87.2 +663.6 663640 1.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ZBTB7B ZNF233 ZNF45 ZNF180 ZNF225 ZNF224 ZNF284 ZNF227 ZNF234 ZNF235 CLASRP
GH19I044206 Promoter/Enhancer 1.6 Ensembl ENCODE 90.6 +611.3 611342 1.7 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF302 ZNF227 ZNF45 ZNF180 ZNF225 ZNF224 ZNF283 ZNF223 ZNF226 ZNF235 ZNF112
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF576 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF576 gene promoter:

Genomic Locations for ZNF576 Gene

Genomic Locations for ZNF576 Gene
chr19:43,596,392-43,601,157
(GRCh38/hg38)
Size:
4,766 bases
Orientation:
Plus strand
chr19:44,100,544-44,105,309
(GRCh37/hg19)

Genomic View for ZNF576 Gene

Genes around ZNF576 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF576 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF576 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF576 Gene

Proteins for ZNF576 Gene

  • Protein details for ZNF576 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H609-ZN576_HUMAN
    Recommended name:
    Zinc finger protein 576
    Protein Accession:
    Q9H609
    Secondary Accessions:
    • Q9BU03

    Protein attributes for ZNF576 Gene

    Size:
    170 amino acids
    Molecular mass:
    D Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF576 Gene

Post-translational modifications for ZNF576 Gene

No Post-translational modifications

Other Protein References for ZNF576 Gene

No data available for DME Specific Peptides for ZNF576 Gene

Domains & Families for ZNF576 Gene

Gene Families for ZNF576 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF576 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for ZNF576 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H609

UniProtKB/Swiss-Prot:

ZN576_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF576: view

Function for ZNF576 Gene

Molecular function for ZNF576 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF576 Gene

Gene Ontology (GO) - Molecular Function for ZNF576 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF576: view
genes like me logo Genes that share phenotypes with ZNF576: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF576 Gene

Localization for ZNF576 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF576 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF576 gene
Compartment Confidence
nucleus 5
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF576 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF576: view

Pathways & Interactions for ZNF576 Gene

SuperPathways for ZNF576 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF576 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF576: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF576 Gene

Drugs & Compounds for ZNF576 Gene

No Compound Related Data Available

Transcripts for ZNF576 Gene

Unigene Clusters for ZNF576 Gene

Zinc finger protein 576:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF576 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1: - - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: -
SP6:

Relevant External Links for ZNF576 Gene

GeneLoc Exon Structure for
ZNF576
ECgene alternative splicing isoforms for
ZNF576

Expression for ZNF576 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF576 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF576 Gene:

ZNF576

SOURCE GeneReport for Unigene cluster for ZNF576 Gene:

Hs.11110

Evidence on tissue expression from TISSUES for ZNF576 Gene

  • Intestine(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF576: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF576 Gene

Orthologs for ZNF576 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF576 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF576 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF576 33
  • 89.02 (n)
cow
(Bos Taurus)
Mammalia ZNF576 33 34
  • 88.43 (n)
zebrafish
(Danio rerio)
Actinopterygii ZNF576 (1 of 2) 34
  • 22 (a)
OneToMany
ZNF576 (2 of 2) 34
  • 2 (a)
OneToMany
Species where no ortholog for ZNF576 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF576 Gene

ENSEMBL:
Gene Tree for ZNF576 (if available)
TreeFam:
Gene Tree for ZNF576 (if available)

Paralogs for ZNF576 Gene

No data available for Paralogs for ZNF576 Gene

Variants for ZNF576 Gene

Sequence variations from dbSNP and Humsavar for ZNF576 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000301047 -- 43,596,524(+) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001605966 -- 43,598,033(+) A/G intron_variant
rs1004602656 -- 43,598,482(+) A/C intron_variant
rs1004888059 -- 43,597,778(+) T/G intron_variant
rs1004940607 -- 43,597,489(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF576 Gene

Variant ID Type Subtype PubMed ID
nsv833839 CNV loss 17160897

Variation tolerance for ZNF576 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF576 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF576

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF576 Gene

Disorders for ZNF576 Gene

Additional Disease Information for ZNF576

No disorders were found for ZNF576 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF576 Gene

Publications for ZNF576 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZNF576 Gene

Sources for ZNF576 Gene

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