Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF574 Gene

Aliases for ZNF574 Gene

  • Zinc Finger Protein 574 2 3 3 5
  • FP972 3

External Ids for ZNF574 Gene

Previous GeneCards Identifiers for ZNF574 Gene

  • GC19P047273
  • GC19P047264
  • GC19P042572
  • GC19P039012

Summaries for ZNF574 Gene

GeneCards Summary for ZNF574 Gene

ZNF574 (Zinc Finger Protein 574) is a Protein Coding gene. An important paralog of this gene is ZNF526.

UniProtKB/Swiss-Prot for ZNF574 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF574 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF574 Gene

Genomics for ZNF574 Gene

GeneHancer (GH) Regulatory Elements for ZNF574 Gene

Promoters and enhancers for ZNF574 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J042074 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 719.9 +8.0 8038 3.8 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC ZNF574 ZNF526 HNRNPUL1 CCDC97 MEGF8 RPS19 ARHGEF1 TMEM145 LOC732229 GRIK5
GH19J042068 Enhancer 0.9 Ensembl ENCODE 662.2 +1.0 1000 2.6 MXI1 ZNF777 ZBTB6 ZNF493 SIN3A NFXL1 ZIC2 ZFHX2 GLIS2 POLR2A ZNF574 ZNF526 HNRNPUL1 CIC CCDC97 GRIK5 GC19P042025
GH19J041294 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 120.7 -765.2 -765180 16.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 CCDC97 ZNF526 HNRNPUL1 SNRPA ZNF574 ENSG00000269843 COQ8B TGFB1 AXL ITPKC
GH19J041348 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 87.7 -716.9 -716864 6.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A YBX1 DMAP1 IRF4 YY1 ZNF213 TMEM91 ENSG00000255730 TGFB1 ZNF526 SNRPA ZNF574 HNRNPUL1 CCDC97 ENSG00000269843 COQ8B
GH19J041261 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 71.3 -803.6 -803627 7.3 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D HNRNPUL1 ZNF526 ZNF574 CCDC97 SNRPA ENSG00000269843 CYP2F2P NUMBL ITPKC ENSG00000271299
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF574 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF574 gene promoter:
  • AP-1
  • c-Jun
  • c-Fos
  • ATF-2
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F

Genomic Locations for ZNF574 Gene

Genomic Locations for ZNF574 Gene
13,091 bases
Plus strand
13,091 bases
Plus strand

Genomic View for ZNF574 Gene

Genes around ZNF574 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF574 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF574 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF574 Gene

Proteins for ZNF574 Gene

  • Protein details for ZNF574 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 574
    Protein Accession:
    Secondary Accessions:
    • Q6IPE0
    • Q6ZN10
    • Q7L5Z5
    • Q8NCE3
    • Q9H6N0

    Protein attributes for ZNF574 Gene

    896 amino acids
    Molecular mass:
    98900 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF574 Gene


neXtProt entry for ZNF574 Gene

Post-translational modifications for ZNF574 Gene

  • Ubiquitination at isoforms=2558 and isoforms=2405
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF574 Gene

Domains & Families for ZNF574 Gene

Gene Families for ZNF574 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF574 Gene


Suggested Antigen Peptide Sequences for ZNF574 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF574: view

Function for ZNF574 Gene

Molecular function for ZNF574 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF574 Gene

Gene Ontology (GO) - Molecular Function for ZNF574 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF574: view
genes like me logo Genes that share phenotypes with ZNF574: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF574 Gene

Localization for ZNF574 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF574 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF574 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF574 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF574: view

Pathways & Interactions for ZNF574 Gene

SuperPathways for ZNF574 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF574 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF574: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF574 Gene

Drugs & Compounds for ZNF574 Gene

No Compound Related Data Available

Transcripts for ZNF574 Gene

Unigene Clusters for ZNF574 Gene

Zinc finger protein 574:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF574 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP3: - - - -
SP4: - - -

Relevant External Links for ZNF574 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF574 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF574 Gene

Protein differential expression in normal tissues from HIPED for ZNF574 Gene

This gene is overexpressed in Lung (42.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF574 Gene

Protein tissue co-expression partners for ZNF574 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF574 Gene:


SOURCE GeneReport for Unigene cluster for ZNF574 Gene:


Evidence on tissue expression from TISSUES for ZNF574 Gene

  • Nervous system(4.7)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with ZNF574: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF574 Gene

Orthologs for ZNF574 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF574 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF574 34
  • 97 (a)
(Bos Taurus)
Mammalia ZNF574 34 33
  • 89.77 (n)
(Canis familiaris)
Mammalia ZNF574 34 33
  • 88.04 (n)
(Mus musculus)
Mammalia Zfp574 16 34 33
  • 87.6 (n)
(Rattus norvegicus)
Mammalia Zfp574 33
  • 87.46 (n)
(Monodelphis domestica)
Mammalia ZNF574 34
  • 86 (a)
(Anolis carolinensis)
Reptilia ZNF574 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf574 33
  • 56.56 (n)
(Danio rerio)
Actinopterygii znf574 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea Y48G8AL.10 34
  • 14 (a)
Species where no ortholog for ZNF574 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF574 Gene

Gene Tree for ZNF574 (if available)
Gene Tree for ZNF574 (if available)
Evolutionary constrained regions (ECRs) for ZNF574: view image

Paralogs for ZNF574 Gene

Variants for ZNF574 Gene

Sequence variations from dbSNP and Humsavar for ZNF574 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000238800 -- 42,068,839(+) G/A coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1000480941 -- 42,081,351(+) A/G 3_prime_UTR_variant
rs1000571702 -- 42,069,746(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000800980 -- 42,075,327(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000853440 -- 42,075,577(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF574 Gene

Variant ID Type Subtype PubMed ID
esv25421 CNV loss 19812545
nsv474593 CNV novel sequence insertion 20440878
nsv520239 CNV loss 19592680
nsv522854 CNV gain 19592680

Variation tolerance for ZNF574 Gene

Residual Variation Intolerance Score: 14.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.38; 71.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF574 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF574 Gene

Disorders for ZNF574 Gene

Additional Disease Information for ZNF574

No disorders were found for ZNF574 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF574 Gene

Publications for ZNF574 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF574 Gene

Sources for ZNF574 Gene

Loading form....