Aliases for ZNF573 Gene

Aliases for ZNF573 Gene

  • Zinc Finger Protein 573 2 3 4 5
  • FLJ30921 2
  • ZNF573 5

External Ids for ZNF573 Gene

Previous GeneCards Identifiers for ZNF573 Gene

  • GC19M042922
  • GC19M042923
  • GC19M038229
  • GC19M034678

Summaries for ZNF573 Gene

GeneCards Summary for ZNF573 Gene

ZNF573 (Zinc Finger Protein 573) is a Protein Coding gene. Diseases associated with ZNF573 include Endocervical Carcinoma and Endocervical Adenocarcinoma. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF780B.

UniProtKB/Swiss-Prot Summary for ZNF573 Gene

Additional gene information for ZNF573 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF573 Gene

Genomics for ZNF573 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF573 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF573 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF573

Top Transcription factor binding sites by QIAGEN in the ZNF573 gene promoter:
  • AML1a
  • C/EBPbeta
  • GATA-1
  • MZF-1
  • NF-1
  • NF-1/L
  • SEF-1 (1)
  • Sox5
  • STAT5A
  • Zic1

Genomic Locations for ZNF573 Gene

Genomic Locations for ZNF573 Gene
chr19:37,735,833-37,817,300
(GRCh38/hg38)
Size:
81,468 bases
Orientation:
Minus strand
chr19:38,226,734-38,307,940
(GRCh37/hg19)
Size:
81,207 bases
Orientation:
Minus strand

Genomic View for ZNF573 Gene

Genes around ZNF573 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF573 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF573 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF573 Gene

Proteins for ZNF573 Gene

  • Protein details for ZNF573 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YE8-ZN573_HUMAN
    Recommended name:
    Zinc finger protein 573
    Protein Accession:
    Q86YE8
    Secondary Accessions:
    • B7WPE1
    • K7EJ45
    • Q6P1P1
    • Q7Z7Q3
    • Q8N2Q1
    • Q96BM3
    • Q96NH0

    Protein attributes for ZNF573 Gene

    Size:
    665 amino acids
    Molecular mass:
    78181 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH42170.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF573 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF573 Gene

Post-translational modifications for ZNF573 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF573 Gene

Domains & Families for ZNF573 Gene

Gene Families for ZNF573 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF573 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF573 Gene

GenScript: Design optimal peptide antigens:
  • ZNF573 protein (Q6PIT4_HUMAN)
  • Zinc finger protein 573 (ZN573_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86YE8

UniProtKB/Swiss-Prot:

ZN573_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF573: view

Function for ZNF573 Gene

Molecular function for ZNF573 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF573 Gene

Gene Ontology (GO) - Molecular Function for ZNF573 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF573: view
genes like me logo Genes that share phenotypes with ZNF573: view

Animal Model Products

CRISPR Products

miRNA for ZNF573 Gene

miRTarBase miRNAs that target ZNF573

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF573

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF573 Gene

Localization for ZNF573 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF573 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF573 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF573 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF573: view

Pathways & Interactions for ZNF573 Gene

PathCards logo

SuperPathways for ZNF573 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF573: view

Pathways by source for ZNF573 Gene

2 Reactome pathways for ZNF573 Gene

Gene Ontology (GO) - Biological Process for ZNF573 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF573: view

No data available for SIGNOR curated interactions for ZNF573 Gene

Drugs & Compounds for ZNF573 Gene

No Compound Related Data Available

Transcripts for ZNF573 Gene

mRNA/cDNA for ZNF573 Gene

5 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF573

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF573 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -

Relevant External Links for ZNF573 Gene

GeneLoc Exon Structure for
ZNF573

Expression for ZNF573 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF573 Gene

Protein differential expression in normal tissues from HIPED for ZNF573 Gene

This gene is overexpressed in Ovary (21.2), Plasma (19.1), Spleen (17.9), and Testis (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF573 Gene



Protein tissue co-expression partners for ZNF573 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF573

SOURCE GeneReport for Unigene cluster for ZNF573 Gene:

Hs.531262

Evidence on tissue expression from TISSUES for ZNF573 Gene

  • Intestine(4.2)
  • Nervous system(4.2)
  • Lung(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZNF573: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF573 Gene

Orthologs for ZNF573 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF573 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia ZNF573 30
  • 84.4 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 53 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
OneToMany
Species where no ortholog for ZNF573 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF573 Gene

ENSEMBL:
Gene Tree for ZNF573 (if available)
TreeFam:
Gene Tree for ZNF573 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF573: view image

Paralogs for ZNF573 Gene

Paralogs for ZNF573 Gene

(555) SIMAP similar genes for ZNF573 Gene using alignment to 8 proteins:

  • ZN573_HUMAN
  • K7EJ45_HUMAN
  • K7EL03_HUMAN
  • K7EM14_HUMAN
  • K7EM47_HUMAN
  • K7EQQ2_HUMAN
  • K7ERS7_HUMAN
  • Q6PIT4_HUMAN

Pseudogenes.org Pseudogenes for ZNF573 Gene

genes like me logo Genes that share paralogs with ZNF573: view

Variants for ZNF573 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF573 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs3752365 -. - p.Gly186Alap.Gly224Ala

Additional dbSNP identifiers (rs#s) for ZNF573 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF573 Gene

Variant ID Type Subtype PubMed ID
esv1564972 CNV deletion 17803354
esv2437108 CNV deletion 19546169
esv2718522 CNV deletion 23290073
esv2718523 CNV deletion 23290073
esv2718524 CNV deletion 23290073
esv2718525 CNV deletion 23290073
esv2718526 CNV deletion 23290073
esv2718527 CNV deletion 23290073
esv2718528 CNV deletion 23290073
esv3644292 CNV loss 21293372
esv3644293 CNV loss 21293372
nsv1129199 CNV insertion 24896259
nsv579468 CNV gain 21841781
nsv833820 CNV loss 17160897

Variation tolerance for ZNF573 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.61; 78.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF573 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF573

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF573 Gene

Disorders for ZNF573 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF573 Gene - From: DISEASES

Disorder Aliases PubMed IDs
endocervical carcinoma
  • carcinoma of endocervix
endocervical adenocarcinoma
  • endocervical carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF573

genes like me logo Genes that share disorders with ZNF573: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF573 Gene

Publications for ZNF573 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3

Products for ZNF573 Gene

Sources for ZNF573 Gene